Neurobehavioral test strategies for environmental exposures in pediatric populations.

The Agency for Toxic Substances and Disease Registry convened a workshop in Atlanta, GA, that evaluated approaches and methods to ascertain whether there are neurobehavioral sequelae to children and adults exposed to hazardous substances in the environment. This article, developed from that workshop, addresses the feasibility of employing extant neurobehavioral tests to screen pediatric populations. A matrix lists basic functions to be assessed during eight developmental periods ranging from birth to high school. The best of these neurobehavioral tests for pediatric populations and the types of assessment tools that are still needed are discussed. We make 10 specific recommendations to establish a hazardous substances neurobehavioral screen for pediatric populations, including appointing a review panel, developing a structured questionnaire, convening a conference on design and analysis, addressing minority and socially disadvantaged populations, coordinating adult and child assessment methods, information sharing among Federal agencies, baseline data, methodology research, research associated with hazardous worksites, and establishment of a pediatric databank.

Narcotics addiction treatment: behavioral methods concurrent with methadone maintenance.

Methadone maintenance patients were assigned among four treatment cells involving contingency management, emotionally-based behavior therapy, a combination of these, or a control condition receiving counseling but no behavioral treatment. With 60 patients who remained in treatment at least 6 months, treatment outcomes were compared using objective measures: hours employed, urinalysis results, and counseling participation. No significant differences were found between modalities. Case studies suggested that under appropriate conditions, contingency management might reduce illicit drug use. It is suggested that focused experimental studies may be more productive than broad clinical outcome evaluations.

Relations between behavioral arousal and plasma cortisol levels in monkeys performing repeated free-operant avoidance sessions.

The commonly believed hypothesis that increases in adrenocorticoid levels sensitively reflect behavioral arousal was tested by subjecting monkeys to repeated sessions of free-operant avoidance; these sessions produced varying degrees of behavioral arousal over time, which were quantified by a behavioral scoring technique. Cortisol was reliably elevated only in the most aroused subjects early in the first avoidance session. Although subjects were still aroused later in the session, cortisol had returned to basal levels. During subsequent avoidance sessions, cortisol returned to basal levels and did not increase significantly even when arousal was further manipulated by the superimposition of unavoidable shock during the final avoidance session. The addition of unavoidable shock was associated with a significant correlation between arousal, as reflected by increases in response rate, and magnitude of change, usually decreases, in mean cortisol levels. The frequent occurrence of dissociations between cortisol levels and behavioral arousal, as reflected by behavioral score, operant rate, and shock frequency, indicates that cortisol levels are of little use as a neuroendocrine index of arousal.

Cardiovascular and subjective effects of intravenous cocaine administration in humans.

Nine volunteer subjects were tested with intravenously administered cocaine hydrochloride in doses ranging from 4 to 32 mg, as well as 10 mg of dextroamphetamine sulfate. Measures of cardiovascular and subjective effects were made. Generally parallel dose-effect functions were obtained for heart rate, blood pressure, Addiction Research Center Inventory scores, Profile of Mood Scales, and subject ratings. A substantial effect on each of these variables was recorded after 8 mg of cocaine. The increase continued and peaked at approximately 16 mg after which it usually leveled off. Ten milligrams of dextroamphetamine generally had an effect comparable to 8 to 16 mg of cocaine.

The evaluation and control of acoustical standing waves.

Calibration of a standard pigeon box subsequently modified for use as an acoustical chamber in a frequency discrimination experiment revealed that the enclosure was not acoustically "flat". Standing waves were detected at each of the six frequencies measured. To ascertain whether the maximum standing waves recorded (3.0 dB) could serve as an added or alternative cue for pigeons tested in the chamber on a frequency discrimination problem, pure-tone intensity difference thresholds were determined for two pigeons at 1.0, 2.0, and 3.0 KHz. The results of the experiment indicated that the smallest intensity difference detectable was 10.0 dB, a value that was 7.0 dB above the maximum standing wave measured in the box. These data suggest that the modified pigeon chamber is suitable to test pure-tone frequency discriminations in pigeons in the range of 1.0 to 3.0 KHz.

Signal frequency and shock probability as determinants of prolonged vigilance performance in rhesus monkeys.

The effects of changing signal frequency on a prolonged vigilance task were investigated by systematically increasing the average inter-trial interval between successive signals. During a 6-hr watch, vigilance performance remained constant when the rate of signal presentation was 40, 20, and 10 per hour. When the rate of signal presentation was reduced to 7 or 4 per hour, marked decrements in detection performance were observed. Similar vigilance decrements occurred when the average rate of signals per hour was kept constant (10 per hour) and the probability of receiving a shock for missing a signal was systematically varied. The results of this study indicate the importance of reinforcement factors in the control and maintenance of vigilance performance.

Second-order optional avoidance as a function of fixed-ratio requirements.

Two rhesus monkeys responded on a fixed-ratio schedule in Stimulus 1 (blue light) to avoid the onset of Stimulus 2 (green light). Failure to avoid Stimulus 2 required a second fixed-ratio performance to avoid Stimulus 3 (red light) in the presence of which unavoidable shock occurred. Relative frequencies of avoidance performance in the blue light and in the green light were inversely related to the ratio requirement under each stimulus condition. Both differential response-cost and avoidance-failure probability factors were related to the observed changes.