[Clinico-morphological manifestations of Pseudomonas infection]. / Kliniko-morfologicheskie proiavleniia sinegnoinoi infektsii.

Various aspects of Pseudomonas aeruginosa infection are covered in the review based on 48 topical Soviet and international publications. Pseudomonosis, caused by opportunistic gram-negative bacteria, is related to human infections often acquired in hospitals and occurs at many sites, the principal ones being respiratory and alimentary tracts. There are cases of severe sepsis. Morphologic signs presenting with alterative changes involve marked circulatory disorders about the necrotic tissue and torpid inflammation, are similar in children and adults. Typical are numerous bacterial colonies at the site of inflammation most pronounced at necrotic foci.

[Pathologic anatomy of Pseudomonas aeruginosa infections in children]. / Patologicheskaia anatomiia sinegnoinoi infektsii u detei.

Examinations of 143 autopsy observations of P. aeruginosa infection in children were performed. Among them, 119 patients had pneumonia, 16 affections of the alimentary tract, 8 sepsis with various localizations of the primary focus. Morphologically the affected organs presented foci of necrosis of different size with tremendous numbers of bacteria, poor leukocyte reaction, and deep circulatory disorders in the periphery. A more manifest leukocyte infiltration in foci of lesions was observed in the cases where other bacterial microflora, in addition to P. aeruginosa, was present. P. aeruginosa isolated from the organs of dead children, as a rule, belonged to immune type 1 or 2 (according to Fisher's scheme). Microbiological studies on these strains showed the most marked necrotic changes to have been caused by microbes having such factors of pathogenicity as protease and plasmocoagulase.