[Treatment results of acute lymphoblastic leukemia in children from centers in Bialostock and Szczecin]. / Wyniki leczenia ostrej bialaczki limfoblastycznej (OBL) u dzieci w osrodkach bialostockim i szczecinskim.

The retrospective analysis was undertaken in order to assess treatment results of childhood ALL achieved in two "independent" units: in Bialystok and Szczecin. It comprised 61 patients: 24 girls and 37 boys aged 10 - 197 months (median 64, mean 73 months), who between November 1987 and December 1992 were diagnosed as having ALL. 25 children, with risk factor greater than 0.8 were classified as intermediate risk patients. ALL 61 children were treated greater than 0.8 were classified as intermediate risk patients. ALL 61 children were treated according to BMF 86 protocol modification of the Polish Leukemia Study Group. The observation was closed in February 1993; the follow-up time was within the range of 10 - 72 months (median 32, mean 32 months). 7 patients (11.5%) did not enter remission, 4 children (6.6%) died in remission and 11 children (18.0%) relapsed. The probability of event-free survival (EFS) and disease-free survival (DFS) were 0.53 and 0.67 respectively. There was no statistical difference in p-EFS between standard and intermediate risk patients (SRG = 0.60 vs IRG = 0.53). It has been shown that p-EFS was not statistically influenced by age, sex, WBC, Hb level, paS-positive and acid-positive ALL. It has been suggested that protocol deviations were the main cause of the inferior (as compared to other domestic centers) treatment results.

Assessment of the character and incidence of electrocardiographic changes in children with simple obesity.

The studied group comprised 82 children with simple obesity. In the group the character and frequency of ECG changes in 12 conventional leads were analyzed. A correlation was established between the character and frequency of these changes and the degree of overweight and obesity duration. In children with simple obesity a considerable prevalence was observed of disturbances of sinus rhythm, impairment of intraventricular conduction and signs of left ventricular hypertrophy. The observed changes were more frequent in children with over 5 years of obesity duration. No correlation was demonstrated between the incidence of these changes and the degree of overweight.