Xanthoma of the Jaw Bones: Cases Series and Review of Literature.

BACKGROUND: Intraosseous xanthomas are rare benign lesions sometimes associated with excess lipid production. Xanthoma of the jaw bones (XJB) was first reported in 1964, and fewer than 50 cases have been reported in the English literature to date. The etiopathogenesis of XJB is highly suggestive of a reactive process or a metabolic condition. METHOD: Seven cases of XJBs were retrieved from the archives of 4 oral and maxillofacial pathology services. Clinical, radiographic and histopathologic features of all these cases were retrospectively analyzed. Immunohistochemical (IHC) stains for S100 and CD68 were performed. RESULTS: All seven cases involved the mandible. Patients' age ranged between 13 and 69 years with an evenly distributed female to male ratio. One patient had a medical history of hyperlipidemia, but the medical and dental histories of the others were unremarkable. For most cases, XJB was an incidental finding discovered during routine radiographic examination. Swelling and cortical expansion were noted in a few cases. Radiographically, cases typically presented as either well-defined multilocular or unilocular lesions, which were either radiolucent or mixed radiolucent/radiopaque. All the lesions were treated with surgical curettage and no recurrence was observed during subsequent follow-ups. Each of the seven cases exhibited sheets of foamy macrophages. The diagnosis is established by exclusion of entities with overlapping microscopic features and involved correlation with the clinical, histological, radiographic and IHC profiles. Immunohistochemically, all the cases expressed diffuse positivity for CD68 and were negative for S100. CONCLUSION: XJB is a rare lesion of unknown etiology, which may mimic other benign or reactive jaw lesions. Due to its rarity and the potential diagnostic challenges it presents, clinicians must remain vigilant and consider CXJ in their differential when assessing radiolucent jaw anomalies.

Mammary analog secretory carcinoma of salivary glands: a report of 2 cases in the lips.

OBJECTIVE: This study presents 2 cases of labial mammary analog secretory carcinoma (MASC) including diagnostic criteria and a review of literature. MASC has not been previously described in the dental literature. DESIGN: Two cases of MASC and 1 case of acinic cell carcinoma (ACC) of the lips were reviewed for their microscopic and immunohistochemical features. Fluorescence in situ hybridization (FISH) for the ETV6-NTRK3 translocation was performed. The clinical features of 65 cases previously described in the medical literature are reviewed. RESULTS: MASCs had hematoxylin and eosin features similar to those of ACC but demonstrated larger, globular periodic acid-Schiff positive deposits, whereas ACC had finer granular deposits. MASCs were strongly positive for S100, vimentin, and mammaglobin, whereas ACC was negative for S100 and vimentin and only focally mammaglobin positive. FISH demonstrated that MASCs were positive for ETV6 disruption. CONCLUSION: MASCs are newly described, can occur in a wide age range, favor males, and can be misinterpreted as ACC or adenocarcinoma not otherwise specified by routine microscopy.

Intraoral minor salivary gland neoplasms: review of 213 cases.

PURPOSE: Minor salivary gland tumors (MSGTs) constitute a heterogeneous group of neoplasms with great histomorphologic variation. This study reviews a large series of benign and malignant salivary gland tumors of the oral region and determines the incidence and the correlation of the histopathologic features with the clinical characteristics. MATERIALS AND METHODS: Two hundred thirteen cases of MSGT were retrospectively studied. Hematoxylin-eosin-stained slides were examined in all cases. Special stains and immunohistochemical stains were used in selected cases. Clinical characteristics of the neoplasms were also noted. RESULTS: One hundred nineteen tumors were benign (56%), and 94 tumors were malignant (44%). Pleomorphic adenoma was the most common benign tumor (93 of 119). Canalicular adenoma was the second most common benign MSGT in our series (25 of 119). Of the 94 malignant MSGTs, mucoepidermoid carcinoma (MEC) (45 of 94), adenoid cystic carcinoma (22 of 94), and polymorphous low-grade adenocarcinoma (18 of 94) were the most common. Most MECs (34 of 45) were low-grade lesions. Of 5 central MECs, 3 cases occurred in the maxilla and 2 cases arose in the mandible. CONCLUSIONS: Benign intraoral MSGTs are slightly more common than malignant MSGTs. Pleomorphic adenoma is the most common MSGT, and MEC is the most common malignant variety. The palate is the most common site for minor gland neoplasms. Benign labial salivary gland neoplasms are more common in the upper lip, and malignant labial tumors are more common in the lower lip.

Case challenge. Mass in the upper lip. Can you make the correct diagnosis?

A 45-year old white woman presented with a chief complaint of a loose crown on the maxillary right central incisor. There was a gray-black pigmented area on the alveolar mucosa in the apical region of the maxillary left central incisor and a firm mass in the left upper lip.

Ameloblastoma of the mandible: a case report.

This report describes the case of a 60-year-old male who presented with a radiolucent lesion between his mandibular right premolars. The original radiographic diagnosis was a lateral periodontal cyst, but surgery produced biopsy material that proved to be an ameloblastoma. A discussion on developing a differential diagnosis is presented.

An open trial of topical tacrolimus for erosive oral lichen planus.

Erosive oral lichen planus is a chronic, painful disease that is frequently refractory to treatment. We describe 6 patients with erosive oral lichen planus, not responsive to topical steroids, who showed substantial improvement with the use of topical tacrolimus ointment 0.1%. This medication was well tolerated and appears to be effective in controlling erosive oral lichen planus.

Angiocentric T-cell lymphoma presenting as midface destructive lesion: case report and literature review.

A case of angiocentric T-cell lymphoma presenting as a midface destructive lesion is reported. Angiocentric T-cell lymphoma typically manifests as an aggressive, progressively destructive, and necrotizing disorder, often with a fatal outcome. This case was characterized microscopically by the presence of an atypical lymphoid population that expressed a CD45+, CD3+ cytoplasmic, CD5+, and CD56- T-cell phenotype within a background of a polymorphous inflammatory infiltrate. Because of the rarity of the disorder, the differential diagnosis is discussed. Recent advances in clinical immunodiagnostics, the variations in therapeutic modalities, and the prognosis of the disease as reported in the recent literature are reviewed.

Prótesis parcial removible

Principios y objetivos del tratamiento con prótesis parciales removibles. Partes de una prótesis parcial removible y sus funciones. El descanso de la prótesis parcial. Consideraciones sobre la unión del diente y el tejido. Conectores mayores. Diseño para los conectores de la base protética. Retenedores: diseño y posición. Tipos de prótesis parciales. Principios en el diseño de una prótesis parcial y la secuencia del diseño. La posición terapéutica más ventajosa. Diagnóstico y planeación del tratamiento. Preparación intrabucal. Impresiones. Comunicaciones e instrucciones con el laboratorio. Ajueste fisiológicos del armazón y los procedimientos de impresión en la técnica del modelo alterado. Relaciones y registros maxilomandibulares. Desarrollo oclusal y estético. Principios y procedimientos de inserción. Preparación del paciente e instrucciones y cuidados posteriores. Procedimientos clínicos y de laboratorio. Métodos de laboratorio. Procedimientos clínicos

Prótesis parcial removible

Principios y objetivos del tratamiento con prótesis parciales removibles. Partes de una prótesis parcial removible y sus funciones. El descanso de la prótesis parcial. Consideraciones sobre la unión del diente y el tejido. Conectores mayores. Diseño para los conectores de la base protética. Retenedores: diseño y posición. Tipos de prótesis parciales. Principios en el diseño de una prótesis parcial y la secuencia del diseño. La posición terapéutica más ventajosa. Diagnóstico y planeación del tratamiento. Preparación intrabucal. Impresiones. Comunicaciones e instrucciones con el laboratorio. Ajueste fisiológicos del armazón y los procedimientos de impresión en la técnica del modelo alterado. Relaciones y registros maxilomandibulares. Desarrollo oclusal y estético. Principios y procedimientos de inserción. Preparación del paciente e instrucciones y cuidados posteriores. Procedimientos clínicos y de laboratorio. Métodos de laboratorio. Procedimientos clínicos