RESUMO
Myeloid cells play a vital role in innate immune responses as they recognize and phagocytose pathogens like viruses, present antigens, produce cytokines, recruit other immune cells to combat infections, and contribute to the attenuation of immune responses to restore homeostasis. Signal integration by pathogen recognition receptors enables myeloid cells to adapt their functions by a network of transcription factors and chromatin remodelers. This review provides a brief overview of the subtypes of myeloid cells and the main epigenetic regulation mechanisms. Special focus is placed on the epigenomic alterations in viral nucleic acids of HIV and SARS-CoV-2 along with the epigenetic changes in the host's myeloid cell compartment. These changes are important as they lead to immune suppression and promote the progression of the disease. Finally, we highlight some promising examples of 'epidrugs' that modulate the epigenome of immune cells and could be used as therapeutics for viral infections.
Assuntos
COVID-19 , Infecções por HIV , Humanos , COVID-19/genética , SARS-CoV-2 , Epigênese Genética , Células Mieloides , Infecções por HIV/genéticaRESUMO
Insuring full benefit of consumer health informatics innovations requires integrating the technology into nursing practice, yet many valuable innovations are developed in research projects and never reach full integration. To avoid this outcome, a team of researchers partnered with a home care agency's staff and patients and their corporate parent's Information Systems and Research group to create a Technology-Enhanced Practice (TEP) designed to enhance care of home bound patients and their family care givers. The technology core of TEP, the HeartCare2 web site, was built in a collaborative process and deployed within the existing patient portal of the clinical partner. This paper describes the innovation and the experience of bringing it into full operation.
Assuntos
Comportamento Cooperativo , Serviços de Assistência Domiciliar , Informática em Enfermagem , Universidades , Humanos , Entrevistas como Assunto , Cuidados de Enfermagem , ObservaçãoAssuntos
Guias como Assunto , Serviços de Assistência Domiciliar/organização & administração , Desenvolvimento de Programas/métodos , Telemedicina/organização & administração , Telemetria/normas , Atitude do Pessoal de Saúde , Serviços Contratados/organização & administração , Tomada de Decisões Gerenciais , Humanos , Equipes de Administração Institucional , Objetivos Organizacionais , Política Organizacional , Equipe de Assistência ao Paciente , Lealdade ao Trabalho , Telemetria/enfermagem , Estados UnidosRESUMO
Urinary incontinence (UI) is a common problem for women of all ages. Associated with poor self-reported health, UI may have a negative effect on women's lifestyle and quality of life. Because UI is not commonly discussed between women or between women and their care providers, the extent of its impact on their lives is not fully understood. This study provides insight into how a woman's perceived or subjective opinion of the severity of UI and her belief in the ability to regain control of UI influence the effectiveness of treatment.