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1.
Behav Brain Res ; 454: 114661, 2023 10 02.
Artigo em Inglês | MEDLINE | ID: mdl-37696453

RESUMO

Precise motor timing requires the ability to flexibly adapt one's own movements with respect to changes in the environment. Previous studies suggest that the correction of perceived as compared to non-perceived timing errors involves at least partially distinct brain networks. The dorsolateral prefrontal cortex (dPFC) has been linked to the correction of perceived timing errors and evidence for a contribution of the ventrolateral PFC (vPFC) specifically to the correction of non-perceived errors exists. The present study aimed at clarifying the functional contribution of the left vPFC for the correction of timing errors by adopting high-definition transcranial direct current stimulation (HD-tDCS). Twenty-one young healthy volunteers synchronized their right index finger taps with respect to an isochronous auditory pacing signal. Perceivable and non-perceivable step-changes of the metronome were interspersed, and error correction was analyzed by means of the phase-correction response (PCR). In subsequent sessions anodal and cathodal HD-tDCS was applied to the left vPFC to establish a brain-behavior relationship. Sham stimulation served as control condition. Synchronization accuracy as well as error correction were determined immediately prior to and after HD-tDCS. The analysis suggests a detrimental effect of cathodal HD-tDCS distinctively on error correction in trials with perceived timing errors. The data support the significance of the left vPFC for error correction in the temporal domain but contradicts the view of a role in the correction of non-perceived errors.


Assuntos
Estimulação Transcraniana por Corrente Contínua , Humanos , Córtex Pré-Frontal , Estado de Consciência , Encéfalo , Córtex Pré-Frontal Dorsolateral
2.
Nanomaterials (Basel) ; 13(4)2023 Feb 04.
Artigo em Inglês | MEDLINE | ID: mdl-36838995

RESUMO

Si1-xGex nanowires (NWs) were prepared by gold-supported chemical vapor deposition (CVD) using a single-source precursor with preformed Si-Ge bonds. Besides the tamed reactivity of the precursor, the approach reduces the process parameters associated with the control of decomposition characteristics and the dosing of individual precursors. The group IV alloy NWs are single crystalline with a constant diameter along their axis. During the wire growth by low pressure CVD, an Au-containing surface layer on the NWs forms by surface diffusion from the substrate, which can be removed by a combination of oxidation and etching. The electrical properties of the Si1-xGex/Au core-shell NWs are compared to the Si1-xGex NWs after Au removal. Core-shell NWs show signatures of metal-like behavior, while the purely semiconducting NWs reveal typical signatures of intrinsic Si1-xGex. The synthesized materials should be of high interest for applications in nano- and quantum-electronics.

3.
Sci Rep ; 12(1): 11586, 2022 07 08.
Artigo em Inglês | MEDLINE | ID: mdl-35803974

RESUMO

Recent advances in neurophysiological brain network analysis have demonstrated novel potential for diagnosis and prognosis of disorders of consciousness. While most progress has been achieved on the population-sample level, time-economic and easy-to-apply personalized solutions are missing. This prospective controlled study combined EEG recordings, basal stimulation, and daily behavioral assessment as applied routinely during complex early rehabilitation treatment. We investigated global characteristics of EEG-derived evolving functional brain networks during the repeated (3-6 weeks apart) evaluation of brain dynamics at rest as well as during and after multisensory stimulation in ten patients who were diagnosed with an unresponsive wakefulness syndrome (UWS). The age-corrected average clustering coefficient C* allowed to discriminate between individual patients at first (three patients) and second assessment (all patients). Clinically, only two patients changed from UWS to minimally conscious state. Of note, most patients presented with significant changes of C* due to stimulations, along with treatment, and with an increasing temporal distance to injury. These changes tended towards the levels of nine healthy controls. Our approach allowed to monitor both, short-term effects of individual therapy sessions and possibly long-term recovery. Future studies will need to assess its full potential for disease monitoring and control of individualized treatment decisions.


Assuntos
Estado Vegetativo Persistente , Vigília , Encéfalo , Estado de Consciência/fisiologia , Humanos , Estado Vegetativo Persistente/diagnóstico , Estudos Prospectivos
4.
Neural Plast ; 2022: 9419154, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35662740

RESUMO

Accurate motor timing requires the temporally precise coupling between sensory input and motor output including the adjustment of movements with respect to changes in the environment. Such error correction has been related to a cerebello-thalamo-cortical network. At least partially distinct networks for the correction of perceived (i.e., conscious) as compared to nonperceived (i.e., nonconscious) errors have been suggested. While the cerebellum, the premotor, and the prefrontal cortex seem to be involved in conscious error correction, the network subserving nonconscious error correction is less clear. The present study is aimed at investigating the functional contribution of the primary motor cortex (M1) for both types of error correction in the temporal domain. To this end, anodal transcranial direct current stimulation (atDCS) was applied to the left M1 in a group of 18 healthy young volunteers during a resting period of 10 minutes. Sensorimotor synchronization as well as error correction of the right index finger was tested immediately prior to and after atDCS. Sham stimulation served as control condition. To induce error correction, nonconscious and conscious temporal step-changes were interspersed in a sequence of an isochronous auditory pacing signal in either direction (i.e., negative or positive) yielding either shorter or longer intervals. Prior to atDCS, faster error correction in conscious as compared to nonconscious trials was observed replicating previous findings. atDCS facilitated nonconscious error correction, but only in trials with negative step-changes yielding shorter intervals. In contrast to this, neither tapping speed nor synchronization performance with respect to the isochronous pacing signal was significantly modulated by atDCS. The data suggest M1 as part of a network distinctively contributing to the correction of nonconscious negative step-changes going beyond sensorimotor synchronization.


Assuntos
Córtex Motor , Estimulação Transcraniana por Corrente Contínua , Humanos , Córtex Motor/fisiologia , Movimento/fisiologia , Córtex Pré-Frontal
5.
Front Aging Neurosci ; 14: 1048610, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36704500

RESUMO

Introduction: Precise motor timing including the ability to adjust movements after changes in the environment is fundamental to many daily activities. Sensorimotor timing in the sub-and supra-second range might rely on at least partially distinct brain networks, with the latter including the basal ganglia (BG) and the prefrontal cortex (PFC). Since both structures are particularly vulnerable to age-related decline, the present study investigated whether age might distinctively affect sensorimotor timing and error correction in the supra-second range. Methods: A total of 50 healthy right-handed volunteers with 22 older (age range: 50-60 years) and 28 younger (age range: 20-36 years) participants synchronized the tap-onsets of their right index finger with an isochronous auditory pacing signal. Stimulus onset asynchronies were either 900 or 1,600 ms. Positive or negative step-changes that were perceivable or non-perceivable were occasionally interspersed to the fixed intervals to induce error correction. A simple reaction time task served as control condition. Results and Discussion: In line with our hypothesis, synchronization variability in trials with supra-second intervals was larger in the older group. While reaction times were not affected by age, the mean negative asynchrony was significantly smaller in the elderly in trials with positive step-changes, suggesting more pronounced tolerance of positive deviations at older age. The analysis of error correction by means of the phase correction response (PCR) suggests reduced error correction in the older group. This effect emerged in trials with supra-second intervals and large positive step-changes, only. Overall, these results support the hypothesis that sensorimotor synchronization in the sub-second range is maintained but synchronization accuracy and error correction in the supra-second range is reduced in the elderly as early as in the fifth decade of life suggesting that these measures are suitable for the early detection of age-related changes of the motor system.

6.
Brain Sci ; 11(2)2021 Feb 09.
Artigo em Inglês | MEDLINE | ID: mdl-33572164

RESUMO

Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that allows the modulation of cortical excitability. TDCS effects can outlast the stimulation period presumably due to changes of GABA concentration which play a critical role in use-dependent plasticity. Consequently, tDCS and learning-related synaptic plasticity are assumed to share common mechanisms. Motor sequence learning has been related to activation changes within a cortico-subcortical network and findings from a meta-analysis point towards a core network comprising the cerebellum as well as the primary motor (M1) and the dorsolateral premotor cortex (dPMC). The latter has been particularly related to explicit motor learning by means of brain imaging techniques. We here test whether tDCS applied to the left dPMC affects the acquisition and reproduction of an explicitly learned motor sequence. To this end, 18 healthy volunteers received anodal, cathodal and sham tDCS to the left dPMC and were then trained on a serial reaction time task (SRTT) with their right hand. Immediately after the training and after overnight sleep, reproduction of the learned sequence was tested by means of reaction times as well as explicit recall. Regression analyses suggest that following cathodal tDCS reaction times at the end of the SRTT training-block explained a significant proportion of the number of correctly reported sequence items after overnight sleep. The present data suggest the left premotor cortex as one possible target for the application of non-invasive brain stimulation techniques in explicit motor sequence learning with the right hand.

7.
Neuropsychologia ; 146: 107555, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32653440

RESUMO

Learning of new motor skills occurs particularly during training on a task (i.e. online) but has been observed between training-blocks lasting up to days after the end of the training (i.e. offline). Offline-learning occurs as further improvement in task performance indicated by increased accuracy and/or faster responses as well as less interference with respect to a distracting condition. Successful motor learning requires the functional interplay between cortical as well as subcortical brain areas. While the involvement of the primary motor cortex in online-as well as early offline-learning is well established, the functional significance of the posterior parietal cortex (PPC) is less clear. Since the PPC may act as sensory-motor interface, a causal involvement in motor learning is conceivable. In order to characterize the functional significance of the left PPC for motor sequence learning, transcranial direct current stimulation (tDCS) was applied either immediately prior to, during or immediately after training on a serial reaction time task (SRTT) in a total of 54 healthy volunteers. While the analysis did not provide evidence for a significant modulation of reaction times during SRTT training (i.e. online-learning), cathodal tDCS decelerated reaction times of the learned sequences as compared to anodal and sham stimulation 30 min after the end of training. The findings suggest that cathodal tDCS over the left parietal cortex interferes with the reproduction of learned sequences.


Assuntos
Aprendizagem/fisiologia , Lobo Parietal/fisiologia , Adulto , Feminino , Humanos , Masculino , Córtex Motor/fisiologia , Plasticidade Neuronal , Tempo de Reação , Estimulação Transcraniana por Corrente Contínua , Adulto Jovem
8.
Neuroimage Clin ; 24: 102057, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31715558

RESUMO

Beta oscillations within motor-cortical areas have been linked to sensorimotor function. In line with this, pathologically altered beta activity in cortico-basal ganglia pathways has been suggested to contribute to the pathophysiology of Parkinson's disease (PD), a neurodegenerative disorder primarily characterized by motor impairment. Although its precise function is still discussed, beta activity might subserve an anticipatory role in preparation of future actions. By reanalyzing previously published data, we aimed at investigating the role of pre-stimulus motor-cortical beta power modulation in motor sequence learning and its alteration in PD. 20 PD patients and 20 healthy controls (HC) performed a serial reaction time task (SRTT) in which reaction time gain presumably reflects the ability to anticipate subsequent sequence items. Randomly varying patterns served as control trials. Neuromagnetic activity was recorded using magnetoencephalography (MEG) and data was reanalyzed with respect to task stimuli onset. Assuming that pre-stimulus beta power modulation is functionally related to motor sequence learning, reaction time gain due to training on the SRTT should vary depending on the amount of beta power suppression prior to stimulus onset. We hypothesized to find less pre-stimulus beta power suppression in PD patients as compared to HC associated with reduced motor sequence learning in patients. Behavioral analyses revealed that PD patients exhibited smaller reaction time gain in sequence relative to random control trials than HC indicating reduced learning in PD. This finding was indeed paralleled by reduced pre-stimulus beta power suppression in PD patients. Further strengthening its functional relevance, the amount of pre-stimulus beta power suppression during sequence training significantly predicted subsequent reaction time advantage in sequence relative to random trials in patients. In conclusion, the present data provide first evidence for the contribution of pre-stimulus motor-cortical beta power suppression to motor sequence learning and support the hypothesis that beta oscillations may subserve an anticipatory, predictive function, possibly compromised in PD.


Assuntos
Ritmo beta/fisiologia , Encéfalo/fisiopatologia , Aprendizagem/fisiologia , Destreza Motora/fisiologia , Doença de Parkinson/fisiopatologia , Tempo de Reação/fisiologia , Eletroencefalografia , Feminino , Humanos , Magnetoencefalografia , Masculino
9.
Neuroimage Clin ; 20: 448-457, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30128283

RESUMO

Motor sequence learning plays a pivotal role in various everyday activities. Motor-cortical beta oscillations have been suggested to be involved in this type of learning. In Parkinson's disease (PD), oscillatory activity within cortico-basal-ganglia circuits is altered. Pathologically increased beta oscillations have received particular attention as they may be associated with motor symptoms such as akinesia. In the present magnetoencephalography (MEG) study, we investigated PD patients and healthy controls (HC) during implicit motor sequence learning with the aim to shed light on the relation between changes of cortical brain oscillations and motor learning in PD with a particular focus on beta power. To this end, 20 PD patients (ON medication) and 20 age- and sex-matched HC were trained on a serial reaction time task while neuromagnetic activity was recorded using a 306-channel whole-head MEG system. PD patients showed reduced motor sequence acquisition and were more susceptible to interference by random trials after training on the task as compared to HC. Behavioral differences were paralleled by changes at the neurophysiological level. Diminished sequence acquisition was paralleled by less training-related beta power suppression in motor-cortical areas in PD patients as compared to HC. In addition, PD patients exhibited reduced training-related theta activity in motor-cortical areas paralleling susceptibility to interference. The results support the hypothesis that the acquisition of a new motor sequence relies on suppression of motor-cortical beta oscillations, while motor-cortical theta activity might be related to stabilization of the learned sequence as indicated by reduced susceptibility to interference. Both processes appear to be impaired in PD.


Assuntos
Ritmo beta/fisiologia , Aprendizagem/fisiologia , Córtex Motor/fisiopatologia , Doença de Parkinson/fisiopatologia , Tempo de Reação/fisiologia , Ritmo Teta/fisiologia , Feminino , Humanos , Magnetoencefalografia/métodos , Masculino , Pessoa de Meia-Idade , Doença de Parkinson/diagnóstico , Estimulação Luminosa/métodos , Distribuição Aleatória
10.
Front Hum Neurosci ; 12: 289, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30072884

RESUMO

Motor sequence learning is associated with the activation of bilateral primary motor cortices (M1). While previous data support the hypothesis that the contralateral M1 is causally involved in the acquisition as well as early consolidation of a motor sequence, the functional significance of the ipsilateral M1 has yet to be solved. Transcranial direct current stimulation (tDCS) allows the non-invasive modulation of cortical excitability. Anodal tDCS applied to the left M1 has been shown to facilitate implicit motor sequence learning of the right hand most likely due to increased excitability. The present study aims at characterizing the functional contribution of the ipsilateral (right) M1 on implicit motor sequence learning of the right hand. To this end, 24 healthy, right-handed subjects received anodal and sham tDCS to the right M1 in a counterbalanced order. Stimulation started 8 min prior to training on a variant of the serial reaction time task (SRTT) with the right hand and persists over the entire training period. The SRTT comprised a fixed eight-digit sequence. A random pattern served as control condition. Reaction times were assessed before and at the end of the acquisition (EoA) immediately after training on the SRTT. The analysis revealed significantly faster reaction times of both hands independent of tDCS condition in sequential trials. However, the gain of reaction times was significantly smaller following anodal as compared to sham tDCS. The data suggest that anodal tDCS applied to the right M1 impairs implicit motor sequence learning of both hands. The underlying mechanism likely involves alterations of the interaction between bilateral M1.

11.
Front Neurosci ; 11: 677, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-29270105

RESUMO

Pitch memory is a resource which is shared by music and language. Neuroimaging studies have shown that the right dorsolateral prefrontal cortex (DLPFC) is activated during pitch memory processes. The present study investigated the causal significance of this brain area for pitch memory in non-musicians by applying cathodal and sham transcranial direct current stimulation (tDCS) over the right DLPFC and examining the impact on offline pitch and visual memory span performances. On the overall sample (N = 22) no significant modulation effect of cathodal stimulation on the pitch span task was found. However, when dividing the sample by means of a median split of pre-test pitch memory abilities into a high and low performing group, a selective effect of significantly impaired pitch memory after cathodal tDCS in good performers was revealed. The visual control task was not affected by the stimulation in either group. The results support previous neuroimaging studies that the right DLPFC is involved in pitch memory processes in non-musicians and highlights the importance of baseline pitch memory abilities for the modulatory effect of tDCS.

12.
Front Hum Neurosci ; 11: 183, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28443012

RESUMO

The synchronization task is a well-established paradigm for the investigation of motor timing with respect to an external pacing signal. It requires subjects to synchronize their finger taps in synchrony with a regular metronome. A specific significance of the posterior parietal cortex (PPC) for superior synchronization in professional drummers has been suggested. In non-musicians, modulation of the excitability of the left PPC by means of transcranial direct current stimulation (tDCS) modulates synchronization performance of the right hand. In order to determine the significance of the left PPC for superior synchronization in drummers, we here investigate the effects of cathodal and anodal tDCS in 20 professional drummers on auditory-motor synchronization of the right hand. A continuation and a reaction time task served as control conditions. Moreover, the interaction between baseline performance and tDCS polarity was estimated in precise as compared to less precise synchronizers according to median split. Previously published data from 16 non-musicians were re-analyzed accordingly in order to highlight possible differences of tDCS effects in drummers and non-musicians. TDCS was applied for 10 min with an intensity of 0.25 mA over the left PPC. Behavioral measures were determined prior to and immediately after tDCS. In drummers the overall analysis of synchronization performance revealed significantly larger tap-to-tone asynchronies following anodal tDCS with the tap preceding the tone replicating findings in non-musicians. No significant effects were found on control tasks. The analysis for participants with large as compared to small baseline asynchronies revealed that only in drummers with small asynchronies tDCS interfered with synchronization performance. The re-analysis of the data from non-musicians indicated the reversed pattern. The data support the hypothesis that the PPC is involved in auditory-motor synchronization and extend previous findings by showing that its functional significance varies with musical expertise.

13.
Behav Brain Res ; 316: 87-93, 2017 01 01.
Artigo em Inglês | MEDLINE | ID: mdl-27542725

RESUMO

While the primary motor cortex (M1) is involved in the acquisition the premotor cortex (PMC) has been related to over-night consolidation of a newly learned motor skill. The present study aims at investigating the possible contribution of the left PMC for the stabilization of a motor sequence immediately after acquisition as determined by susceptibility to interference. Thirty six healthy volunteers received anodal, cathodal and sham transcranial direct current stimulation (tDCS) to the left PMC either immediately prior to or during training on a serial reaction time task (SRTT) with the right hand. TDCS was applied for 10min, respectively. Reaction times were measured prior to training (t1), at the end of training (t2), and after presentation of an interfering random pattern (t3). Beyond interference from learning, the random pattern served as control condition in order to estimate general effects of tDCS on reaction times. TDCS applied during SRTT training did not result in any significant effects neither on acquisition nor on susceptibility to interference. In contrast to this, tDCS prior to SRTT training yielded an unspecific facilitation of reaction times at t2 independent of tDCS polarity. At t3, reduced susceptibility to interference was found following cathodal stimulation. The results suggest the involvement of the PMC in early consolidation and reveal a piece of evidence for the hypothesis that behavioral tDCS effects vary with the activation state of the stimulated area.


Assuntos
Lateralidade Funcional/fisiologia , Aprendizagem/fisiologia , Córtex Pré-Frontal/fisiologia , Estimulação Transcraniana por Corrente Contínua/métodos , Adulto , Método Duplo-Cego , Potencial Evocado Motor/fisiologia , Feminino , Humanos , Masculino , Neuronavegação , Tempo de Reação/fisiologia , Fatores de Tempo , Adulto Jovem
14.
Front Behav Neurosci ; 10: 4, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-26834593

RESUMO

The primary motor cortex (M1) contributes to the acquisition and early consolidation of a motor sequence. Although the relevance of M1 excitability for motor learning has been supported, the significance of M1 oscillations remains an open issue. This study aims at investigating to what extent retrieval of a newly learned motor sequence can be differentially affected by motor-cortical transcranial alternating (tACS) and direct current stimulation (tDCS). Alpha (10 Hz), beta (20 Hz) or sham tACS was applied in 36 right-handers. Anodal or cathodal tDCS was applied in 30 right-handers. Participants learned an eight-digit serial reaction time task (SRTT; sequential vs. random) with the right hand. Stimulation was applied to the left M1 after SRTT acquisition at rest for 10 min. Reaction times were analyzed at baseline, end of acquisition, retrieval immediately after stimulation and reacquisition after eight further sequence repetitions. Reaction times during retrieval were significantly faster following 20 Hz tACS as compared to 10 Hz and sham tACS indicating a facilitation of early consolidation. tDCS yielded faster reaction times, too, independent of polarity. No significant differences between 20 Hz tACS and tDCS effects on retrieval were found suggesting that 20 Hz effects might be associated with altered motor-cortical excitability. Based on the behavioral modulation yielded by tACS and tDCS one might speculate that altered motor-cortical beta oscillations support early motor consolidation possibly associated with neuroplastic reorganization.

15.
Behav Brain Res ; 294: 141-8, 2015 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-26254878

RESUMO

Brain imaging studies highlighted structural differences in congenital amusia, a life-long perceptual disorder that is associated with pitch perception and pitch memory deficits. A functional anomaly characterized by decreased low gamma oscillations (30-40 Hz range) in the right dorsolateral prefrontal cortex (DLPFC) during pitch memory has been revealed recently. Thus, the present study investigates whether applying transcranial alternating current stimulation (tACS) at 35 Hz to the right DLPFC would improve pitch memory. Nine amusics took part in two tACS sessions (either 35 Hz or 90 Hz) and completed a pitch and visual memory task before and during stimulation. 35 Hz stimulation facilitated pitch memory significantly. No modulation effects were found with 90 Hz stimulation or on the visual task. While amusics showed a selective impairment of pitch memory before stimulation, the performance during 35 Hz stimulation was not significantly different to healthy controls anymore. Taken together, the study shows that modulating the right DLPFC with 35 Hz tACS in congenital amusia selectively improves pitch memory performance supporting the hypothesis that decreased gamma oscillations within the DLPFC are causally involved in disturbed pitch memory and highlight the potential use of tACS to interact with cognitive processes.


Assuntos
Transtornos da Percepção Auditiva/fisiopatologia , Transtornos da Percepção Auditiva/terapia , Memória de Curto Prazo/fisiologia , Percepção da Altura Sonora/fisiologia , Córtex Pré-Frontal/fisiopatologia , Estimulação Transcraniana por Corrente Contínua/métodos , Estimulação Acústica , Transtornos da Percepção Auditiva/psicologia , Feminino , Humanos , Masculino , Música , Testes Neuropsicológicos , Índice de Gravidade de Doença , Detecção de Sinal Psicológico/fisiologia , Percepção Visual/fisiologia , Adulto Jovem
16.
Behav Brain Res ; 293: 234-40, 2015 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-26225845

RESUMO

At present it remains elusive to what extent motor-cortical alpha (8-12Hz) and beta (13-30Hz) oscillations are associated with motor sequence learning. In order to interact with motor-cortical oscillations, the present study applied transcranial alternating current stimulation (tACS) at 10Hz, 20Hz and sham stimulation over the left primary motor cortex (M1) during a serial reaction time task (SRTT) in 13 healthy volunteers. In a control experiment, tACS at 35Hz was applied in another sample of 13 volunteers. The participants performed the task with the right hand. A sequential pattern was interleaved by a randomly varying pattern serving as interference from sequence learning. Reaction times were determined as dependent variable. Both 10 and 20Hz tACS facilitated SRTT acquisition in contrast to sham and 35Hz tACS. After acquisition, the interfering condition led to increased reaction times comparable to baseline level during 10Hz, sham and 35Hz tACS. In contrast, during 20Hz tACS the initial learning success was retained despite interference. While motor-cortical tACS at 10 and 20Hz likewise facilitates the acquisition, tACS at 20Hz frequency additionally stabilizes the newly learned motor sequence indicated by less susceptibility to interference.


Assuntos
Potencial Evocado Motor/fisiologia , Aprendizagem/fisiologia , Córtex Motor/fisiologia , Movimento/fisiologia , Estimulação Transcraniana por Corrente Contínua , Análise de Variância , Biofísica , Método Duplo-Cego , Feminino , Mãos/inervação , Humanos , Masculino , Desempenho Psicomotor , Tempo de Reação/fisiologia , Fatores de Tempo , Adulto Jovem
17.
Cortex ; 64: 310-7, 2015 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-25577719

RESUMO

Brain stimulation studies have previously demonstrated a causal link between general pitch memory processes and activity within the left supramarginal gyrus (SMG). Building on this evidence, the present study tested the impact of left SMG stimulation on two distinct pitch memory phases, retention and encoding. Repetitive transcranial magnetic stimulation (rTMS) was employed during the retention stage (Experiment 1) and the encoding phase (Experiment 2) of a pitch recognition task. Stimulation was applied on a trial-by-trial basis over the left SMG (target site) or the vertex (control site). A block without TMS was also completed. In Experiment 1, rTMS over the left SMG during pitch retention led to significantly increased reaction times compared to control conditions. In Experiment 2 no rTMS modulation effects were found during encoding. Experiment 3 was conducted as a control for non-specific stimulation effects; no effects were found when rTMS was applied over the left SMG at the two different time points during a perceptual task. Taken together, these findings highlight a phase-specific involvement of the left SMG in the retention phase of pitch memory, thereby indicating that the left SMG is involved in the maintenance of pitch information.


Assuntos
Lobo Parietal/fisiologia , Percepção da Altura Sonora/fisiologia , Retenção Psicológica/fisiologia , Adolescente , Adulto , Feminino , Humanos , Masculino , Música , Tempo de Reação/fisiologia , Estimulação Magnética Transcraniana , Adulto Jovem
18.
Brain Stimul ; 7(6): 800-6, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25216648

RESUMO

BACKGROUND: Flexible and precisely timed motor control is based on functional interaction within a cortico-subcortical network. The left posterior parietal cortex (PPC) is supposed to be crucial for anticipatory motor control by sensorimotor feedback matching. OBJECTIVE: Intention of the present study was to disentangle the specific relevance of the left PPC for anticipatory motor control using transcranial direct current stimulation (tDCS) since a causal link remains to be established. METHODS: Anodal vs. cathodal tDCS was applied for 10 min over the left PPC in 16 right-handed subjects in separate sessions. Left primary motor cortex (M1) tDCS served as control condition and was applied in additional 15 subjects. Prior to and immediately after tDCS, subjects performed three tasks demanding temporal motor precision with respect to an auditory stimulus: sensorimotor synchronization as measure of anticipatory motor control, interval reproduction and simple reaction. RESULTS: Left PPC tDCS affected right hand synchronization but not simple reaction times. Motor anticipation was deteriorated by anodal tDCS, while cathodal tDCS yielded the reverse effect. The variability of interval reproduction was increased by anodal left M1 tDCS, whereas it was reduced by cathodal tDCS. No significant effects on simple reaction times were found. CONCLUSION: The present data support the hypothesis that left PPC is causally involved in right hand anticipatory motor control exceeding pure motor implementation as processed by M1 and possibly indicating subjective timing. Since M1 tDCS particularly affects motor implementation, the observed PPC effects are not likely to be explained by alterations of motor-cortical excitability.


Assuntos
Antecipação Psicológica/fisiologia , Lateralidade Funcional/fisiologia , Lobo Parietal/fisiologia , Adulto , Método Duplo-Cego , Feminino , Mãos/fisiologia , Humanos , Masculino , Córtex Motor/fisiologia , Tempo de Reação/fisiologia , Estimulação Transcraniana por Corrente Contínua , Adulto Jovem
19.
Front Hum Neurosci ; 7: 511, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-24009573

RESUMO

Synchronous oscillatory activity at alpha (8-12 Hz), beta (13-30 Hz), and gamma (30-90 Hz) frequencies is assumed to play a key role for motor control. Corticomuscular coherence (CMC) represents an established measure of the pyramidal system's integrity. Transcranial alternating current stimulation (tACS) offers the possibility to modulate ongoing oscillatory activity. Behaviorally, 20 Hz tACS in healthy subjects has been shown to result in movement slowing. However, the neurophysiological changes underlying these effects are not entirely understood yet. The present study aimed at ascertaining the effects of tACS at 10 and 20 Hz in healthy subjects on CMC and local power of the primary sensorimotor cortex. Neuromagnetic activity was recorded during isometric contraction before and at two time points (2-10 min and 30-38 min) after tACS of the left primary motor cortex (M1), using a 306 channel whole head magnetoencephalography (MEG) system. Additionally, electromyography (EMG) of the right extensor digitorum communis (EDC) muscle was measured. TACS was applied at 10 and 20 Hz, respectively, for 10 min at 1 mA. Sham stimulation served as control condition. The data suggest that 10 Hz tACS significantly reduced low gamma band CMC during isometric contraction. This implies that tACS does not necessarily cause effects at stimulation frequency. Rather, the findings suggest cross-frequency interplay between alpha and low gamma band activity modulating functional interaction between motor cortex and muscle.

20.
Exp Neurol ; 247: 178-81, 2013 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-23664959

RESUMO

Parkinson's disease (PD) is a common neurodegenerative disorder owing to loss of dopaminergic cells. Akinesia - one of the core symptoms of PD - is associated with exaggerated oscillations at beta frequency (13-30 Hz) within the subthalamic nucleus (STN). Thus, enhanced oscillations below 30 Hz are assumed to represent a pathophysiological marker of PD. However, recent data suggest that OFF medication exaggerated beta oscillations within basal ganglia (BG) cortical networks may serve for the compensation of BG dysfunctions. The STN is functionally connected to mesial prefrontal areas like the supplementary motor area (SMA). But, it is still not fully understood how enhanced beta oscillations within the BG exert dominance over the primary motor cortex (M1) thereby yielding motor impairment. The present study, therefore, investigates the effect of dopaminergic state on SMA-M1 functional connectivity using Magnetoencephalography (MEG). MEG data were recorded in 7 patients suffering from PD with preponderance of akinesia during isometric contraction of the right forearm and during rest. Coherence as a measure of functional connectivity between M1 and SMA was calculated OFF and ON medication and correlated with the motor part of the Unified Parkinson's Disease Rating Scale (UPDRS III) and with disease duration. During rest a significant positive correlation between disease duration and SMA-M1 coherence was found ON but not OFF medication. Conversely, during isometric contraction SMA-M1 coherence and UPDRS III were inversely correlated OFF but not ON medication explaining more than 80% of variance. The results favor the hypothesis that OFF medication exaggerated cortical coherence at beta frequency represents a compensatory mechanism rather than a pathophysiological marker per se.


Assuntos
Ritmo beta/fisiologia , Córtex Motor/fisiopatologia , Doença de Parkinson/patologia , Doença de Parkinson/fisiopatologia , Núcleo Subtalâmico/fisiopatologia , Idoso , Gânglios da Base/fisiopatologia , Mapeamento Encefálico , Eletroencefalografia , Eletromiografia , Feminino , Humanos , Modelos Lineares , Magnetoencefalografia , Masculino , Pessoa de Meia-Idade , Índice de Gravidade de Doença
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