RESUMO
The effectiveness of different treatment programs was studied in correlation with clinical characteristics of chronic glomerulonephritis (CGN) in 665 patients. It was established that the higher was CGN activity, the poorer were the treatment results. Nephrotic syndrome also had negative implications. The best response was brought by prolonged (1-2.5 years) course of corticosteroids and cytostatics.
Assuntos
Glomerulonefrite/tratamento farmacológico , Glucocorticoides/uso terapêutico , Imunossupressores/uso terapêutico , Adulto , Doença Crônica , Preparações de Ação Retardada/uso terapêutico , Quimioterapia Combinada , Feminino , Glomerulonefrite/patologia , Humanos , Masculino , Resultado do TratamentoRESUMO
The results of long-term follow-up (from 4 to 25 years) were studied in 1420 patients with chronic glomerulonephritis registered in the city nephrologic service of Leningrad. The relapses ceased in 45.8% and became less frequent in 16% of cases. The survival rate of long-term follow-up patients was significantly higher than of those observed for 2-3.5 years. Long remissions and slowing down of the disease progression were obtained mostly in cases with mild or moderate process activity and seldom in patients with frequent and persisting relapses: Long-term results did not significantly depend on hypertension or nephrotic syndrome but worsened in membrano-proliferative, sclerotic glomerulonephritis and focal glomerulosclerosis due to their inclination to relapse.
Assuntos
Glomerulonefrite/terapia , Adulto , Doença Crônica , Feminino , Seguimentos , Glomerulonefrite/mortalidade , Glomerulosclerose Segmentar e Focal/terapia , Humanos , Masculino , Pessoa de Meia-Idade , Síndrome Nefrótica/terapia , Recidiva , Fatores de TempoRESUMO
Industrial production of plague monoclonal antibodies in mice BALB/c was shown possible. Precipitation of the immunoglobulins with caprylic acid provided the highest purity of the preparations. Maintenance of the specific activity by the monoclonal antibodies was stable. The immunoenzymatic conjugate and erythrocytic diagnosticum on the basis of the monoclonal antibodies are sensitive, specific and may be used in antiplague practice.
