RESUMO
The evaluation of the quality of external radiotherapy plans in patients with cervical cancer was performed. There was analyzed homogeneity index in the target volume (PTV), conformity index and others for 53 patients. Homogeneity and conformity indexes within the tolerances were achievable in the clinic with the implementation of technology 3D CRT, IMRT and Rapid Arc. The rectum and the bladder dose for 38% of patients irradiated by -of IMRT and Rapid Arc methods was significantly less compared to the 3D CRT and was in average 31 Gy. This reflected the benefits of these technologies for radiation exposure to critical organs.
Assuntos
Fracionamento da Dose de Radiação , Neoplasias do Colo do Útero/radioterapia , Adulto , Feminino , HumanosRESUMO
Cervical cancer takes second place in morbidity and third place in mortality from gynecological cancer. Advanced stages among newly diagnosed cases is still large. The "gold standard" of treatment for locally advanced cervical cancer is chemoradiotherapy with cisplatin that results in a lower risk of death. Improvement of radiotherapy methods allowed to bring optimal dose to the primary tumor with the inclusion of regional metastasis areas with less risk of damage to surrounding healthy tissue and organs. The search for alternative combinations of cytostatics, modes of drug administration, adjuvant chemotherapy after chemoradiotherapy showed an increase in survival of patients with locally advanced cervical cancer.
Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Quimiorradioterapia , Neoplasias do Colo do Útero/terapia , Quimiorradioterapia/métodos , Quimiorradioterapia Adjuvante , Cisplatino/administração & dosagem , Ensaios Clínicos como Assunto , Fracionamento da Dose de Radiação , Esquema de Medicação , Feminino , Fluoruracila/administração & dosagem , Humanos , Análise de Sobrevida , Resultado do Tratamento , Neoplasias do Colo do Útero/tratamento farmacológico , Neoplasias do Colo do Útero/patologia , Neoplasias do Colo do Útero/radioterapiaRESUMO
The immediate and end results of combined radiotherapy for cervical carcinoma stages I-III conducted at the N.N. Blokhin Center's Clinic (1982-1996) were compared. Intracavitary irradiation was carried out using the following radiation sources: 60Co-AGAT-V (208); 137Cs-Selectron (96) and 252Cf-ANET-V and ANET-VA (115). Remote-control irradiation procedure was identical in all groups. Five-year survival for stage I was 85.1% +/- 6.2; 85.7% +/- 13.1 and 87.8% +/- 1.2; stage II--67.5% +/- 4.0; 61% +/- 8.5 and 76.6 +/- 3.2; stage III--43.6% +/- 6.8; 57.7% +/- 9.6 and 70.9% +/- 5.4, respectively. Ten-year survival for stage I was 56.9% +/- 15.1; 85.4% +/- 13.1 and 80.1% +/- 1.5; stage II--65% +/- 5.2; 46.5% +/- 8.7 and 70.7% +/- 3.5; stage III--42% +/- 8.8; 51.3 +/- 9.9 and 64.6% +/- 6.2, respectively.
