[Drug monitoring of the antibacterial drug Vancomycin in patients with purulent-inflammatory diseases of the maxillofacial region]. / Lekarstvennyi monitoring antibakterial'nogo preparata vankomitsin u patsientov s gnoino-vospalitel'nymi zabolevaniyami chelyustno-litsevoi oblasti.

THE AIM OF THE STUDY: To evaluate the change in the level of concentration of the antibacterial drug Vancomycin registered in the purulent focus area (facial vein) and in the peripheral blood flow (cubital vein) in patients with phlegmon of the maxillofacial region (MFR). MATERIALS AND METHODS: The clinical material of the study was 12 patients with phlegmon of MFR who were being treated in the maxillofacial department of the N.I. Pirogov State Clinical Hospital No. 1 of the Moscow Medical Center. The drainage of phlegmons was performed on the day of admission of the patient 2-3 days after the onset of the disease. The phlegmons involved two or more spaces of the MFR. As an antimicrobial drug, 500 mg of Vancomycin in 400 ml of saline solution was used intravenously. Quantitative registration of Vancomycin was carried out 2 hours after intravenous infusion. Blood sampling was carried out from the cubital and facial veins in an amount of 7-8 ml intraoperatively at the opening of the phlegmon, under endotracheal anesthesia. The concentration of the antibiotic was determined by high-performance liquid crystal chromatography. RESULTS AND DISCUSSION: The study found that the concentration of Vancomycin in the facial vein exceeds similar indicators obtained from the cubital vein. The difference in the percentage ratio averaged 19.2±7.3%. In 10 patients with phlegmons of various localization, it was found that the penetration of the antibacterial drug into the tissues of the inflammatory focus is higher compared to the periphery. However, in a number of patients, the concentration of the drug did not exceed the minimum suppressive concentration recommended for obtaining a therapeutic effect (for Vancomycin, it is at least 2 mcg / ml). CONCLUSION: To achieve the therapeutic effect of phlegmon treatment, it is necessary to select an individual dose of the drug for each patient.

[COVID-induced facial bones necrosis]. / COVID-indutsirovannyi nekroz chelyustnykh kostei.

The article focuses on the clinical manifestation of inflammatory and destructive lesions of the bones of the midface, nose and paranasal sinuses as a long-term complication of COVID-19 with clinical examples provided.

[Experience of the interdisciplinary approach to diagnostics and treatment of patients with bisphosphonate osteonecrosis of the upper jaw]. / Opyt mezhdistsiplinarnogo podkhoda k diagnostike i lecheniiu patsientov s bisfosfonatnym osteonekrozom verkhnei cheliusti.

The article discusses the issues of diagnosis, the clinical course of osteonecrosis of the upper jaw in patients with oncological diseases. The assessment of radiological indicators of bone pathology of the upper jaw, signs of the development of the inflammatory process of the maxillary sinus and other sinuses of the nose. The experience of conservative tactics and surgical treatment of patients in this group is analyzed with the participation of specialists from otorhinolaryngologists and maxillofacial surgeons.

[The possibility for the early diagnosis of suppurative-inflammatory wound complications of the maxillofacial area and neck by using an acoustic skin analyzer]. / Vozmozhnost' rannei diagnostiki gnoino-vospalitel'nykh oslozhnenii ran cheliustno-litsevoi oblasti i shei s pomoshch'iu akusticheskogo kozhnogo analizatora.

The acoustic method was used for early diagnosis of pyo-inflammatory complications of wounds of the maxillofacial area and neck. Acoustic skin analyzer was used. The velocities of acoustic wave propagation (Vx, Vy) were notably increased in the pyo-inflammatory focus in comparison with perifocal tissues and with the symmetrical contralateral side. The difference in the absolute values of velocities was about 45-65 m/s. No acoustic anisotropy was observed in the focus of inflammation. Hence, the acoustic method can be used as a method for early diagnosis of pyo-inflammatory complications and for monitoring the wound status in the course of wound process.

[An electron microscopic study of the origins of the projections of the first auditory area of the cortex (AI) to the medial geniculate body in cats]. / Elektronno-mikroskopicheskoe issledovanie istochnikov proektsii pervoi slukhovoi oblasti kory (AI) v medial'noe kolenchatoe telo u koshek.

An electron microscope study of retrogradely labelled neurons in layer VI of the primary auditory cortex (AI) after injection of the horseradish peroxidase to the medial geniculate body was carried out in cats. Three-eight synapses (4.6 +/- 0.6 at an average) were revealed on the somata profiles of these retrogradely labelled cortico-geniculate neurons. Synapses occupied 10.8 +/- 1.0% of the somatic profile of cortico-geniculate neurons. Almost all (98.7%) of these axosomatic synapses had symmetrical contacts and were formed by axonal terminals with small elongated synaptic vesicles. HRP retrogradely labelled axonal terminals of geniculo-cortical fibres were revealed in neuropil of layer VI. They contained large round synaptic vesicles and formed asymmetrical synapses, mainly on spines. The role of axo-somatic synapses in regulation of the activity of cortico-geniculate neurons was discussed.