RESUMO
Pseudomelanosis coli occurs after prolonged intake a anthranoids. After discontinuation of intake the pigmentation disappears apparently without noxious effects, including carcinogenicity and genotoxicity. We are presenting ESR spectra of pseudomelanosis coli specimen, compared to ESR spectra of pigmented skin scales taken from psoriatic patients treated topically with anthralin, and with ESR spectra of anthralin brown material formed in vitro. The ESR spectra show comparable g values within the accuracy of measurements. The examined specimens reveal remarkable stability: the intensity of the ESR signal remained practically constant over the period of four years. The chemical and physicochemical properties of the brown pigments formed from anthranoids explain the observed bio-inertness of these materials including that of melanosis coli pigment derived from anthranoids.
Assuntos
Antralina/efeitos adversos , Antralina/metabolismo , Catárticos/efeitos adversos , Catárticos/metabolismo , Doenças do Colo/induzido quimicamente , Doenças do Colo/metabolismo , Mucosa Intestinal/química , Administração Tópica , Anti-Inflamatórios/efeitos adversos , Anti-Inflamatórios/uso terapêutico , Colo/química , Espectroscopia de Ressonância de Spin Eletrônica , Radicais Livres , Humanos , Psoríase/tratamento farmacológico , Psoríase/metabolismo , Pele/químicaRESUMO
The preparation of immunologically active phthalimido desmuramylpeptide analogues 2e-h, 4c-d, and 7b is described. The N-acetylmuramic acid in the muramyl dipeptide has been replaced by a phthaloylated acyclic moiety such as N-phthaloylated amino acids 1a-c, 2-(2-phthalimidoethoxy)acetic acid 3, or by the carbocyclic rac. trans-2-(2'-phthalimidocyclohexyloxy)acetic acid 6.
