Challenges in conducting clinical research in primary care dentistry.

The integration of dentistry into primary health care is crucial for promoting patient well-being. However, clinical studies in dentistry face challenges, including issues with study design, transparency, and relevance to primary care. Clinical trials in dentistry often focus on specific issues with strict eligibility criteria, limiting the generalizability of findings. Randomized clinical trials (RCTs) face challenges in reflecting real-world conditions and using clinically relevant outcomes. The need for more pragmatic approaches and the inclusion of clinically relevant outcomes (CROs) is discussed, such as tooth loss or implant success. Solutions proposed include well-controlled observational studies, optimized data collection tools, and the integration of artificial intelligence (AI) for predictive modelling, computer-aided diagnostics and automated diagnosis. In this position paper advocates for more efficient trials with a focus on patient-centred outcomes, as well as the adoption of pragmatic study designs reflecting real-world conditions. Collaborative research networks, increased funding, enhanced data retrieval, and open science practices are also recommended. Technology, including intraoral scanners and AI, is highlighted for improving efficiency in dental research. AI is seen as a key tool for participant recruitment, predictive modelling, and outcome evaluation. However, ethical considerations and ongoing validation are emphasized to ensure the reliability and trustworthiness of AI-driven solutions in dental research. In conclusion, the efficient conduct of clinical research in primary care dentistry requires a comprehensive approach, including changes in study design, data collection, and analytical methods. The integration of AI is seen as pivotal in achieving these objectives in a meaningful and efficient way.

[Root canal post for build-up restorations: necessary or redundant?] / Wortelstift bij funderingsrestauraties: noodzakelijk of overbodig?

The purpose of root canal posts is to obtain additional retention for build-up restorations of endodontically treated teeth so they can be functionally reconstructed. Due to developments in adhesive dentistry and a lack of clinical evidence, root canal posts are used less and less. Currently, the advice of the European Society of Endodontology is to use a root canal post only in front teeth and premolars in the absence of remaining coronal dentine walls. It is important to avoid additional preparation when placing a root canal post, because this causes (additional) weakness of the tooth. The loss of dental tissue due to preparation cannot be compensated for by placing a post.

Clinical survival and performance of premolars restored with direct or indirect cusp-replacing resin composite restorations with a mean follow-up of 14 years.

OBJECTIVES: The objective is to evaluate the long-term clinical survival and performance of direct and indirect resin composite restorations replacing cusps in vital upper premolars. METHODS: Between 2001 and 2007, 176 upper premolars in 157 patients were restored with 92 direct and 84 indirect resin composite restorations as part of an RCT. Inclusion criteria were fracture of the buccal or palatal cusp of vital upper premolars along with a class II cavity or restoration in the same tooth. RESULTS: Forty patients having 23 direct and 22 indirect composite restorations respectively, were lost to follow-up (25.6%). The cumulative Kaplan-Meier survival rates were 63.6% (mean observation time: 15.3 years, SE 5.6%) with an AFR of 2.4% for direct restorations and 54.5% (mean observation time: 13.9 years, SE: 6.4%) with an AFR of 3.3% for indirect restorations. The Cox regression analysis revealed a statistically significant influence of the patient's age at placement on the survival of the restoration (HR 1.036, p = 0.024), the variables gender, type of upper premolar, type of restoration, and which cusp involved in the restoration had no statistically significant influence. Direct composite restorations failed predominantly due to tooth fracture, indirect restorations primarily by adhesive failure (p < 0.05). SIGNIFICANCE: There was no statistically significant difference in survival rates between direct and indirect composite cusp-replacing restorations. Both direct and indirect resin composite cusp-replacing restorations are suitable options to restore compromised premolars. The longer treatment time and higher costs for the indirect restoration argue in favor of the direct technique.

Randomized controlled trial on the performance of direct and indirect composite restorations in patients with severe tooth wear.

OBJECTIVE: The study aimed to evaluate survival and failure behavior of Direct Composite Restorations (DRC) and Indirect Composite Restorations (ICR) on molars and anterior teeth, in a Randomized Controlled Trial (RCT). METHODS: Patients with generalized severe tooth wear were included, and randomly assigned to one of 2 protocols: (1) DCR: All teeth were restored with directly applied micro-hybrid composite restorations (Clearfil AP-X, Kuraray) for load bearing areas and nano-hybrid composite restorations (IPS Empress Direct, Ivoclar Vivadent) for buccal veneers; (2) ICR: First molars were restored with indirect composite 'tabletop' restorations and maxillary anterior teeth were restored with indirect palatal veneer restorations (Clearfil Estenia C&B, cemented with Panavia F, Kuraray). Remaining teeth were restored directly. Restorations were evaluated after 3 years, focusing on clinical acceptability. Statistical analysis was performed using Kaplan Meier curves, Annual Failure Rates (AFRs), and univariate Cox regression analyses (p < 0.05). RESULTS: 41 patients (age: 36.6 ± 6.6y) were evaluated after 3 years (40.0 ± 2.2 m). 408 restorations on first molars and palatal veneers on maxillary anterior teeth were part of this RCT, with 220 DCRs and 188 ICRs. No differences in survival between treatment modality for palatal veneers for any failure criteria were found. Tabletop restorations on first molars showed a considerable higher failure rate for ICR compared to DCR (p = 0.026, HR: 3.37, 95%CI = 1.16-9.81). SIGNIFICANCE: In this RCT, directly applied composite restorations showed superior behavior compared to the indirect composite restorations, when used in the molar region.

Clinical performance of full rehabilitations with direct composite in severe tooth wear patients: 3.5 Years results.

OBJECTIVES: To evaluate the mid-term clinical performance of direct composite restorations placed in patients with pathological tooth wear needing full rehabilitation with an increase of vertical dimension of occlusion. METHODS: In a prospective trial 34 patients (34.0 ±â€¯8.4 years; 25 males, 9 females) were treated with a minimal invasive additive technique using composite restorations. The restorative treatment protocol was to provide all teeth with composite build-up restorations in an increased vertical dimension of occlusion (VDO) using the DSO-technique. Recall appointments were planned after 1 month, 1 and 3 years after treatment. Restorations were scored for clinically acceptability (FDI-criteria) and scores 4 and 5 were recorded as clinically unacceptable. Frequencies of failures and Kaplan Meier survival curves are presented and effect of relevant variables was calculated with a multifactorial Cox regression (p < 0.05). RESULTS: 1256 Restorations were placed, 687 anterior, 324 premolar, and 245 molar restorations. After a mean observation time of 39.7 months a total of 69 failures were observed, of which 61 restorations were repaired (score 4) and 8 were replaced (score 5). Most common reasons for failure were (chip) fractures (n = 43) and caries (n = 11). Placement of anterior restorations in two sessions led to significant 4.6 times more failures then placed in one session. CONCLUSIONS: In patients with severe tooth wear a full rehabilitation, in an increased vertical dimension of occlusion, direct composite resin restorations show a 94.8% success and 99.3% survival rate after a period of 3.5 years.

[Instruction in dental radiology]. / Scholing in de tandheelkundige radiologie.

The diagnostic use of oral radiology is an essential part of daily dental practice. Due to the potentially harmful nature of ionising radiation, the clinical use of oral radiology in the Netherlands is framed by clinical practice guidelines and regulatory requirements. Undergraduate students receive intensive theoretical and practical training in practical and theoretical radiology, with the aim of obtaining the 'Eindtermen Stralingshygiëne voor Tandartsen en Orthodontisten'-certificate, which is required for legal permission to use oral radiology in dental practice. It is recommended that the curriculum be expanded to include the areas of knowledge required to qualify for the 'Eindtermen Stralingshygiëne voor het gebruik van CBCT-toestellen door tandartsen' (the certificate for the use of conebeam radiology by dentists). The general dental practitioner is faced with changing laws and regulations in all areas of practice. One of the most significant legal changes in the field of dental radiology was the introduction of the new radiation protection and safety rules in 2014. Moreover, a large group of dentists is also being confronted with the transition from conventional to digital images, with all its challenges and changes in everyday practice.

Crown vs. composite for post-retained restorations: A randomized clinical trial.

OBJECTIVES: This randomized clinical trial compared the survival of composite resin restorations and metal-ceramic crowns on endodontically treated teeth that received a glass fiber post using 2 different cementation methods. METHODS: Forty-seven patients (age 42.5 ± 11.5) with fifty-seven endodontically treated teeth with extensive coronal damage but always with one intact surface were randomly allocated according to the type of coronal restoration: metal-ceramic crown or composite resin. In case of crown restoration, a core buildup was performed with microhybrid composite resin. The dentin bonding agent and composite resin used were the same for both direct and indirect restorations. Descriptive analysis was performed using FDI clinical criteria and survival of restorations/teeth analyzed using Kaplan-Meier statistics and log-rank tests. RESULTS: 57 restorations (30 composite resin and 27 crowns) were made in 47 patients. The recall rate was 100% and follow up time ranged between 1 and 5 years. One tooth was extracted 11 months post-restoration due to root fracture (composite group). Eight composite restorations and one crown had reparable failures, all due to secondary caries or restoration fracture. The overall annual failure rate (AFR) was 0.92% after 50 months for success of the restorations, with 1.83% for the composite group and 0.26% for the metal-ceramic crown group. The log-rank test showed no difference for survival according to the type of restoration (p=0.344). However, for success rates, metal-ceramic crowns demonstrated better performance (p=0.022). CONCLUSIONS: Indirect restorations provided higher acceptable clinical performance and lower need for re-intervention, but both types of restorations presented good survival rates. (NCT01461239). CLINICAL SIGNIFICANCE: When endodontically treated teeth with at least one intact surface must be restored, composite resin restorations and metal-ceramic crows are acceptable alternatives to achieve good survival and success rates.

Case Report: A Predictable Technique to Establish Occlusal Contact in Extensive Direct Composite Resin Restorations: The DSO-Technique.

This paper describes the application technique of direct shaping by occlusion (DSO) for large composite restorations including the entire occlusal surface. For this technique, matrix bands and wedges are inserted without interference with antagonists in the desired occlusion. The final increment of soft-composite resin is shaped by letting the patient occlude on the uncured composite. Due to the nature of the technique, special care has to be taken for moisture control and handling of contamination. The procedure, advantages, and limitations of the technique are discussed.

Occlusal wear and occlusal condition in a convenience sample of young adults.

OBJECTIVE: To study progression of tooth wear quantitatively in a convenient sample of young adults and to assess possible correlations with occlusal conditions. METHODS: Twenty-eight dental students participated in a three-year follow up study on tooth wear. Visible wear facets on full arch gypsum casts were assessed using a flatbed scanner and measuring software. Regression analyses were used to assess possible associations between the registered occlusal conditions 'occlusal guidance scheme', 'vertical overbite', 'horizontal overbite', 'depth of sagittal curve', 'canine Angle class relation', 'history of orthodontic treatment', and 'self-reported grinding/clenching' (independent variables) and increase of wear facets (dependent variable). RESULTS: Mean increase in facet surface areas ranged from 1.2 mm2 (premolars, incisors) to 3.4 mm2 (molars); the relative increase ranged from 15% to 23%. Backward regression analysis showed no significant relation for 'group function', 'vertical overbite', 'depth of sagittal curve', 'history of orthodontic treatment' nor 'self-reported clenching. The final multiple linear regression model showed significant associations amongst 'anterior protected articulation' and 'horizontal overbite' and increase of facet surface areas. For all teeth combined, only 'anterior protected articulation' had a significant effect. 'Self reported grinding' did not have a significant effect (p>0.07). CONCLUSIONS: In this study 'anterior protected articulation' and 'horizontal overbite', were significantly associated with the progression of tooth wear. Self reported grinding was not significantly associated with progression of tooth wear. CLINICAL SIGNIFICANCE: Occlusal conditions such as anterior protected articulation and horizontal overbite seem to have an effect on the progression of occlusal tooth wear in this convenient sample of young adults.

[Technical aspects of treatments with single- and multi-unit fixed dental prostheses]. / Tandtechnische aspecten van de vervaardiging van kronen en bruggen.

For the manufacture of single- and multi-unit fixed dental prostheses, effective communication between dentist and dental technician is required. Mutual insight concerning the (im)possibilities of available treatments and technical options is prerequisitefor this communication. The manufacture of single- and multi-unit fixed dental prostheses involves 4 phases: recording the required detailed information on the relevant teeth and the occlusal system, the technical adjustments, the technical design and the technical fabrication. These phases can be accomplished through an analogue or (semi)digital procedure. Pioneering developments are computer aided design and computer aided manufacturing (CAD/CAM), and computerised milling machines. Associated with this are 3 manufacturing methods which can be distinguished: the dental practice method, the dental laboratory method and the milling centre method. Materials applied are metal alloys and ceramics, while resins are used for provisional and transitional constructions. Due to the fact that the choice of material in the analogue procedure is limited, CAD/CAM offers more options, the digital procedure is expected to gain ground gradually. It is expected that this development will provide an impulse to higher quality.

Randomized control trial of composite cuspal restorations: five-year results.

The objective of this randomized control trial was to compare the five-year clinical performance of direct and indirect resin composite restorations replacing cusps. In 157 patients, 176 restorations were made to restore maxillary premolars with Class II cavities and one missing cusp. Ninety-two direct and 84 indirect resin composite restorations were placed by two operators, following a strict protocol. Treatment technique and operator were assigned randomly. Follow-up period was at least 4.5 yrs. Survival rates were determined with time to reparable failure and complete failure as endpoints. Kaplan-Meier five-year survival rates were 86.6% (SE 0.27%) for reparable failure and 87.2% (SE 0.27%) for complete failure. Differences between survival rates of direct and indirect restorations [89.9% (SE 0.34%) vs. 83.2% (SE 0.42%) for reparable failure and 91.2% (SE 0.32%) vs. 83.2% (SE 0.42%) for complete failure] were not statistically significant (p = .23 for reparable failure; p = .15 for complete failure). Mode of failure was predominantly adhesive. The results suggest that direct and indirect techniques provide comparable results over the long term (trial registration number: ISRCTN29200848).

[Determining and recording maxillomandibular relationships for the fabrication of single-unit and multi-unit fixed dental prostheses]. / Bepaling en registratie van de maxillomandibulaire relatie bij de vervaardiging van kronen en bruggen.

In a correctly functioning occlusal system, the design of the occlusal parts of single-unit and multi-unit fixed dental prostheses is generally determined by the maximum intercuspation. Determining and recording the maxillomandibular relationships is only required in case the adjacent teeth do not offer adequate support or reference to put the maxillary and mandibular cast in maximum intercuspation or in case the existing occlusion needs a well-structured alteration. The maxillomandibular relationships can be determined and registered analogously and digitally and on that basis the maxillary and mandibular casts can be mounted in a (virtual) occludator or articulator. In the absence of a distinct occlusal plane, one may consider first carrying out a facebow recording and transfer. Usually, the accuracy of determining and recording the maxillomandibular relationships does not increase when using more complicated methods.

[Attaching single- and multi-unit fixed dental prostheses]. / Bevestiging van kronen en bruggen.

A single- or multi-unit fixed dental prosthesis can be attached to the abutment teeth through mechanical retention and gap sealing or by adhesion. For sealing the gap, water-soluble cements are appropriate, such as zinc phosphate, polycarboxylate, and (resin-modified) glasionomer cement. Attachment through adhesion can be performed with composite cement. If the hard tooth tissue is prepared adequately, composite cement provides sufficient adhesion, but self-adhesive composite cement is now also available. For the adhesion of the composite cement to the restorative materials of the single- or multi-unit fixed dental prosthesis, surface sandblasting, silanizing, and tin coating and the application of a metal primer or chemically active composite are available. Cementing a single- or multi-unit dental prosthesis involves 3 phases: 1. Cleansing the single- or multi-unit dental prosthesis and the abutment tooth/teeth; 2. Preparing the hard tooth tissue, mixing the cement and placing the single- or multi-unit dental prosthesis; 3. Removing the excess cement.

[The conventional and the digital impression method for single-unit and multi-unit fixed dental prostheses]. / De conventionele en de digitale afdrukmethode voor kronen en bruggen.

To manufacture single-unit and multi-unit fixed dental prostheses, an accurate cast is required. Casts can be obtained either by the conventional or the digital impression method. For both methods, dry tooth surfaces and a well exposed finish line of the tooth preparation are required. The conventional impression method requires an elastic impression material. Elastomers have a high detail accuracy, which can produce, in combination with a good fitting and rigid impression tray, an impression with reliable dimensional stability. Based on the number of different impression material consistencies used and the number ofphases of the impression procedure, several options of the conventional impression method can be distinguished. For the digital impression method, teeth or implants are scanned to produce a digital cast which can be used directly with the help of computer technology to produce single-unit or multi-unit fixed dental prostheses. The digital impression method has a number of advantages when compared to the conventional impression method, but is not applicable for all prosthetic cases.

[Contact wear related to single- and multi-unit dental prostheses]. / Contactslijtage in relatie tot kronen en bruggen.

Occlusal surfaces of teeth and restorations wear by repeated antagonistic contact. Two-body wear is the result of direct contact between occlusal surfaces. In cases of three-body wear, food is found between antagonistic teeth. Contact wear is expressed predominantly by abrasion and material fatigue. Erosion is a type of wear which does not involve direct antagonistic contact. Qualitative methods exist for registering occlusal tooth wear. Wear of restorations can be measured using casts. An obvious method for comparing rates of wear of restorative materials is laboratory research. This method has demonstrated that the wear rates of composite and enamel are similar. Cast metals and in particular ceramic wear less than enamel. The relation between oral factors and the rate of tooth wear is not always clear. Wellpolished surfaces of restorations wear less quickly and have less effect on the wearing of antagonistic teeth than rougher restoration surfaces.

[Build-up restorations after extensive loss of tooth tissue]. / Funderings restauraties bij uitgebreid weefselverlies van gebitselementen.

After (extensive) loss of tooth tissue, vital teeth can be built up completely with composite restoration material. Sometimes, the application of additional retentive preparations is indicated. In exceptional cases, a root canal treatment is indicated, following which a root canal post is applied if necessary. Endodontically treated multi-rooted teeth can be built up entirely with composite, utilizing the pulp chamber and root canal accesses for retention. However, in single-rooted teeth a root canal post is necessary, in which case a prefabricated root post is used. Traditionally, metal posts were used in combination with a cast, indirect build-up restoration. Subsequently, directly fabricated cores, combining metal posts with amalgam or, at the present time, composite restoration material, became customary. The present trend is to use prefabricated or individually fabricated fibre-reinforced posts. After restoring a tooth with a build-up restoration, a combined build-up restoration can be chosen, or a direct or indirect crown single tooth prosthesis.

[Resin-bonded fixed partial dentures]. / Adhesiefbruggen.

A resin-bonded fixed partial denture is a prosthetic construction which can replace I or several teeth in an occlusal system and which comprises a pontic element which is adhesively attached to 1 or more abutment teeth. To compensate for the limited shear strength of the adhesive layer, the Jixed partial denture is occlusally supported by the abutment(s). A direct resin-bonded fixed partial denture is made of composite, reinforced or not by a frame of flexible metal or fiber material. For an indirect resin-bonded fixed partial denture, a metal, fibre-reinforced composite or ceramic substructure is fabricated in a dental laboratory. The basic principle of a resin-bonded fixed partial denture is minimal invasiveness. However, a restoration in an abutment tooth requires a certain occlusal space which is realized by tooth preparation. Resistance preparations may be performed to improve the longevity of resin-bonded fixed partial dentures. Both financially and biologically, a resin-bonded bridge is a cost-effective prosthetic construction. The longevity is limited, but when the construction fails the negative consequences for the abutments are generally limited, which leaves open several types of other treatments.

[The integration of science in the clinical dental programme at the University of Nijmegen]. / Integratie van wetenschap in de kliniek van de Nijmeegse opleiding tandheelkunde.

To be able to make a well founded clinical decision on the basis of evidence, the concept of 'evidence based practice' offers a solution by making it possible to select the appropriate knowledge from the increasing amount of scientific clinical information. Competence is required to put the concept (combining the best available scientific clinical evidence, experience and skills of the dentist and preferences of the patient) into practice. To prepare the undergraduate student for future clinical practice, the Nijmegen dental school has adopted evidence based practice to be implemented from the first year of dental training. The experiences of both students and lecturers are modest. The probable reason is that many clinical decisions are (can be) taken on the basis of experience and routine. The challenge is to base life-long learning on the practice of evidence based dentistry.

[Education and dental practice offer possibilities to exchange competences]. / Onderwijs en praktijk bieden mngelijkheden tot uitwisseling van vaardigheden.

The 3 dental schools in the Netherlands have the same goals for their graduates, in terms of knowledge and skills, but the contents of the curricula are different. The curricula are all based on the pillars of scientific education, medical education, dental education, and professionalism. Within this construction a student is trained as the manager of an oral health team. At graduation, the new generation of dentists have many (new) competences and relatively limited clinical experience and need support in acquiring clinical experience. Moreover, dentists who have recently graduated may be faced with methods and materials to which they were not introduced in their educational programme. A dentist with considerable clinical experience can test the newly acquired competences of the new generation ofdentists, with the benefit of a critical eye, against (routine) daily practices.

Swallowing threshold parameters of subjects with shortened dental arches.

OBJECTIVES: To quantify swallowing threshold parameters of subjects with a moderate shortened dental arch dentition (SDA: missing molar teeth, but premolar teeth in occluding position and uninterrupted anterior regions) compared to subjects with a complete dental arch dentition (CDA). METHODS: Fourteen females with SDA (3-4 occlusal premolar units) and 14 females with CDA were instructed to chew silicone test 'food' (cubic particles with a total volume of 3 cm(3)). They spit it out the moment they felt the urge to swallow and the pulverized particles were collected. Swallowing threshold parameters were number of chewing cycles, time until 'swallowing', and median particle size of the pulverized particles as determined by sieving the food. Chewing tests were performed twice and outcomes were averaged. RESULTS: The number of chewing cycles until 'swallowing' of subjects with SDA was approximately 1.7 times (p<0.005) that of the controls and this took approximately 1.6 times more time (p<0.01). The median particle size until 'swallowing' did not differ significantly between the groups, but demonstrated large individual differences. Regression analyses indicated that the ratio of median particle size until 'swallowing' of SDA and CDA becomes progressively unfavourable for SDA with increasing numbers of chewing cycles. CONCLUSIONS: Subjects with SDA pulverized test 'food' particles to sizes comparable to subjects with CDA, but chewed longer with more chewing cycles until 'swallowing'. Higher numbers of chewing cycles were associated with increasing difference between SDA and CDA regarding the median particle size until 'swallowing'. CLINICAL SIGNIFICANCE: Compared to subjects with CDA, subjects with moderate SDA pulverize test food particles to comparable size by chewing longer before "swallowing". Therefore, overloading the digestive system by swallowing courser food particles is unlikely in SDA. Consequently, replacement of absent molars just to optimize chewing function is not advised.