1.
Org Lett
; 8(10): 2103-6, 2006 May 11.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16671792
RESUMO
[reaction: see text] Pyrrolidine-2,4-diones (1) are naturally occurring analogues of amino acids. We herein present a facile synthesis of N-acylated, O-alkylated pyrrolin-2-ones (2) in high yield and excellent enantiopurity. Molecular mechanics calculations suggest that the resulting dipeptide analogues adopt a linear, extended conformation.