[Embryotoxic effects of deoxynivalenol mycotoxin (vomitoxin) in rats]. / Embriotoksicheskoe deistvie mikotoksina dezoksinivalenola (vomitoksina) na krys.

Study of embryotoxic action of deoxynivalenol in levels of 0.2, 1, 5, 10 mg/kg from 7 to 15 day of rat pregnancy was worked up. The 0.2 mg/kg determined as a maximal acceptable dose without toxic effects.

[Biological action of different forms of lead in the rat diet]. / O biologicheskom deistvii razlichnykh form svintsa v sostave pishchego ratsiona krys.

The effects of the inclusion of biologically bound lead and PbCl2 into the diet of rats were studied. The lead dose with reference to ion was 0.65 mg/kg bw. The experiments lasted 10 days. As compared with aqueous solution of lead chloride, biologically bound lead the source of which was liver of the cattle kept on the diet supplemented with lead for a long time produced a more overt unfavourable action on porphyrin metabolism as judged from the excretion of delta-aminolevulinic acid with urine and hemoglobin level. The concentration of lead in the liver of rats fed biologically bound lead was elevated, whereas the amount of lead excreted with urine was less. No principal differences in the manifestations of lead poisoning and accumulation in organs and tissues were discovered whatever the animal group.

[State of rat embryogenesis and progeny during exposure to foreign substances contained in the food]. / Issledovanie sostoianiia émbriogeneza i potomstva krys pri vozdeistvii psotoronnikh veshchestv, soderzhashchikhsia v pishche.

Examination of the action of different xenobiotics (pesticides, heavy metals) on embryogenesis and progeny allowed the methodological approaches to this line of research to be suggested. It is recommended that xenobiotics be administered in different periods of embryogenesis: from day 1 to day 7, from day 7 to day 15 and from day 1 to day 20. It has been established that at cross mating the most pronounced alterations arose in the progeny of experimental males. The main object was to study the effect dependence on the dose, time and administration of the substances in order to establish their threshold and subthreshold levels. Validation of these parameters required the use of a complex of integral, functional, biochemical and morpholgical findings that warrant as assessment of the changes from the standpoint of the entire body, individual systems, organs, cellular and subecellular structures.