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Int J Mol Sci ; 13(4): 4982-4992, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22606024

RESUMO

A novel family of tetraaza macrocyclic Cu(II) complexes [CuLX(2)] (where L = N(4) donor macrocyclic ligands) and (X = Cl(-), NO(3) (-)) have been synthesized and characterized by elemental analysis, magnetic moments, IR, EPR, mass, electronic spectra and thermal studies. The magnetic moments and electronic spectral studies suggest square planar geometry for [Cu(DBACDT)]Cl(2) and [Cu(DBACDT)](NO(3))(2) complexes and distorted octahedral geometry to the rest of the ten complexes. The biological activity of all these complexes against gram-positive and gram-negative bacteria was compared with the activity of existing commercial antibacterial compounds like Linezolid and Cefaclor. Six complexes out of twelve were found to be most potent against both gram-positive as well as gram-negative bacteria due to the presence of thio group in the coordinated ligands.


Assuntos
Antibacterianos/farmacologia , Compostos Aza/farmacologia , Bactérias Gram-Negativas/efeitos dos fármacos , Bactérias Gram-Positivas/efeitos dos fármacos , Compostos Macrocíclicos/farmacologia , Acetamidas/farmacologia , Antibacterianos/análise , Antibacterianos/química , Compostos Aza/análise , Compostos Aza/química , Cefaclor/farmacologia , Cobre/química , Linezolida , Compostos Macrocíclicos/análise , Compostos Macrocíclicos/química , Espectroscopia de Ressonância Magnética , Testes de Sensibilidade Microbiana , Oxazolidinonas/farmacologia , Espectrofotometria Infravermelho
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