[Taurocholic acid synthesis in dogs maintained on a high cholesterol diet]. / Sintez taurokholevoi kisloty pri soderzhanii sobak na giperkholesterinovoi diete.

Labeled 35S-taurocholic acid synthesis was studied in dogs with gall bladder fistulae, fed high cholesterol diet. During the first period (1--2 months) dietary cholesterol caused a significant increase in the 35S-taurocholic acid synthesis. In 5--6 months, at the period of development of the pathological process in the liver, there was a decrease of synthesis and secretion of bile acids, and of cholesterol sediment in the bile. The level of plasma cholesterol in these dogs increased only slightly.

[Intensity of glycolysis and energy metabolism in erythrocytes in experimental hypervitaminosis A]. / Intensivnost' glikoliza i énergeticheskii obmen v éritrotsitakh pri éksperimental'nom A-gipervitaminoze

Administration of 60,000 i.e. of vitamin A into rats within three weeks caused an increase in amount of reticulocytes, in the rate of glucose utilization and in formation of lactic acid by erythrocytes. The activity of glycolytic enzymes was intensified. The activity of hexokinase was increased by 84.6%, activities of aldolase and phosphohexoisomerase were increased by 34%. But in the erythrocytes content of AMP, ADP and ATP was unaltered, probably due to activation of total and Na+, K+-dependent ATPase. The harmful effect of an excess of the vitamin A was manifested in an increased content of Na+ in erythrocytes and also in decreased stability of the cells to acid hemolytics.

[Effect of long-term vitamin A administration on the acid fastness and biochemical properties of erythrocytes]. / Vliianie dlitel'nogo vvedeniia vitamina A na killotnuiu rezistentnost' i biokhimicheskie svoistva éritrotsitov

A long-term administration of retinol in a dose exceeding 15-fold the diurnal requirement to rats weighing 170-200 g provoked a diminution of the erythrocytes resistance to an acid hemolytic, an intensified uptake of glucose, and increased activity of glycolytic enzymes (hexokinase, aldolase, phosphohexoisomerase), accumulation of lactate, along with changes in the redox enzymes activity, suppression of the catalase and intensification of peroxidase activity. The content of microergic nucleotides and electrolites (Na+ and K+) remained unchanged.