RESUMO
Frequency distribution of HLA antigens of A and B loci was examined in 138 adolescent boys aged 14-18 with delayed sexual development (DSD) of stages I-III, residing in the north-eastern region of Ukraine. Increase of A28- and B40-antigens and haplotypes A1-B40, A28-B40, A10-B40 determination frequencies was established. There were revealed positive and negative correlation between some of HLA antigens and DSD. Relative and attributive risks of DSD formation were calculated.
Assuntos
Antígenos HLA/genética , Puberdade Tardia/genética , Adolescente , Alelos , Distribuição de Qui-Quadrado , Frequência do Gene , Haplótipos , Humanos , Masculino , Fenótipo , Puberdade Tardia/imunologia , Fatores de Risco , UcrâniaRESUMO
The pedigrees of 192 girls aged 14.19 with different forms of hyperandrogenism (HA) have been studied. The hirsutism has been taken as a main symptom in analysis of pedigrees. The verification of different models of HA inheritance allows considering HA to be a multifactorial disease which is inherited as a quasi-alternative model. The coefficient of heritability is equal to 0.65-1.0.
