Production of radioactive particles for endovascular therapeutic interventions.

Recanalization is a common phenomenon that decreases the efficacy of embolization procedures. It can be inhibited by beta-radiation. Two novel ways of producing radioactive particles are described, by neutron beam irradiation of gold-containing microspheres, or by using the 32P binding capacity of zirconium-containing microspheres. Particles were tested in vivo, to assess their ability to deliver radioactivity locally, using canine renal artery, porcine rete mirabile, and rabbit ear embolization models. Both radioactive microspheres (198Au and 32P) showed no detectable activity outside the target territory. 32P microspheres demonstrated typical radiation changes in a porcine rete mirabile arteriovenous malformation model.

Cesium Ion Pair Acidities of some N,N-Dialkylacetamides and Aggregation of Their Cesium Enolates in Tetrahydrofuran.

Cesium ion pair acidities are reported of some N,N-dialkylacetamides at 25 degrees C in tetrahydrofuran. The cesium enolates of alpha-arylacetamides are essentially monomeric at concentrations of about 10(-)(4) M, but small amounts of dimers are present for the enolates of N,N-dimethyl- and N,N-diethyl(4-biphenylyl)acetamide (K(dimer) is approximately 400 M(-)(1)). The cesium enolate of N,N-dimethyldiphenylacetamide forms small amounts of dimers, but the dimerization constant of <100 M(-)(1) is near the limit of detection of our methods. The enolate of N,N-diethylacetamide has an average aggregation number of 3.3, consistent with a mixture of dimers and tetramers. The cesium ion pair pKs of the alpha-arylacetamides are about 25-26, and that of N,N-diethylacetamide is greater than 33.7. The acidity data are in good agreement with measurements that have been reported in the literature for similar systems.