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1.
Front Behav Neurosci ; 13: 143, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31404254

RESUMO

Exposure to stress during the early postnatal period (i.e., early life stress, ES) can impact brain physiology and modify individual variability in adult social behavior. Arginine vasopressin (AVP) and oxytocin (OXT) are two centrally released neuropeptides that are involved in shaping essential social behaviors, like aggression, social recognition, and social motivation. AVP and OXT modulate activity in brain regions important for the establishment of social behavior, and may be particularly sensitive to ES. In this review, we discuss whether ES alters the characteristics of the AVP- and OXT- systems in rodents, and whether these changes are associated with later alterations in aggression, social recognition, and social motivation. We have integrated causal studies indicating that (1) ES affects AVP/OXT, and (2) that changing AVP/OXT in affected regions alters social behavior. Although there is encouraging evidence that ES causes AVP- and OXT-system changes, and that these may mediate social behavior, a comprehensive understanding of the exact nature of AVP- and OXT changes and whether they are causal in establishing these behavioral disturbances needs further investigation. As there are indications that ES alters AVP- and OXT characteristics in humans as well, and that these may interact with adult predisposition to psychopathology with social dysfunction, future rodent studies may lay ground for a better understanding of such changes in humans. Ultimately, this may assist in developing therapeutic strategies to target ES effects on social behavior.

2.
eNeuro ; 4(5)2017.
Artigo em Inglês | MEDLINE | ID: mdl-29098176

RESUMO

Early life adversity is a well-known risk factor for behavioral dysfunction later in life, including the formation of contextual memory; it is also (transiently) accompanied by hyperactivity of the stress system. We tested whether mifepristone (MIF) treatment, which among other things blocks glucocorticoid receptors (GRs), during the prepubertal period [postnatal days (PND)26-PND28] normalizes memory deficits in adult male rats exposed to 24-h maternal deprivation (MD) at PND3. MD reduced body weight gain and increased basal corticosterone (CORT) levels during the PND26, but not in adulthood. In adulthood, contextual memory formation of MD compared to noMD (i.e., control) male rats was significantly impaired. This impairment was fully prevented by MIF treatment at PND26-PND28, whereas MIF by itself did not affect behavior. A second behavioral test, a rodent version of the Iowa Gambling Task (rIGT), revealed that flexible spatial learning rather than reward-based aspects of performance was impaired by MD; the deficit was prevented by MIF. Neuronal activity as tested by c-Fos staining in the latter task revealed changes in the right hippocampal-dorsomedial striatal pathway, but not in prefrontal areas involved in reward learning. Follow-up electrophysiological recordings measuring spontaneous glutamate transmission showed reduced frequency of miniature postsynaptic excitatory currents in adult CA1 dorsal hippocampal and enhanced frequency in dorsomedial striatal neurons from MD versus noMD rats, which was not seen in MIF-treated rats. We conclude that transient prepubertal MIF treatment normalizes hippocampus-striatal-dependent contextual memory/spatial learning deficits in male rats exposed to early life adversity, possibly by normalizing glutamatergic transmission.


Assuntos
Encéfalo/efeitos dos fármacos , Privação Materna , Transtornos da Memória/tratamento farmacológico , Mifepristona/administração & dosagem , Neurônios/efeitos dos fármacos , Nootrópicos/administração & dosagem , Animais , Encéfalo/crescimento & desenvolvimento , Encéfalo/fisiopatologia , Corticosterona/metabolismo , Potenciais Pós-Sinápticos Excitadores/efeitos dos fármacos , Ácido Glutâmico/metabolismo , Masculino , Memória/efeitos dos fármacos , Memória/fisiologia , Transtornos da Memória/etiologia , Transtornos da Memória/fisiopatologia , Potenciais Pós-Sinápticos em Miniatura/efeitos dos fármacos , Neurônios/fisiologia , Distribuição Aleatória , Ratos Wistar , Receptores de Glucocorticoides/antagonistas & inibidores , Receptores de Glucocorticoides/metabolismo , Aprendizagem Espacial/efeitos dos fármacos , Aprendizagem Espacial/fisiologia , Estresse Psicológico/complicações , Estresse Psicológico/tratamento farmacológico , Estresse Psicológico/fisiopatologia , Técnicas de Cultura de Tecidos , Aumento de Peso/efeitos dos fármacos
3.
Front Behav Neurosci ; 9: 374, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26858618

RESUMO

Early-life stress (ELS) is a risk factor for the development of psychopathology, particularly in women. Human studies have shown that certain haplotypes of NR3C2, encoding the mineralocorticoid receptor (MR), that result in gain of function, may protect against the consequences of stress exposure, including childhood trauma. Here, we tested the hypothesis that forebrain-specific overexpression of MR in female mice would ameliorate the effects of ELS on anxiety and memory in adulthood. We found that ELS increased anxiety, did not alter spatial discrimination and reduced contextual fear memory in adult female mice. Transgenic overexpression of MR did not alter anxiety but affected spatial memory performance and enhanced contextual fear memory formation. The effects of ELS on anxiety and contextual fear were not affected by transgenic overexpression of MR. Thus, MR overexpression in the forebrain does not represent a major resilience factor to early life adversity in female mice.

5.
Nat Rev Neurosci ; 11(10): 675-81, 2010 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-20820185

RESUMO

The acquisition and consolidation of memories of stressful events is modulated by glucocorticoids, a type of corticosteroid hormone that is released in high levels from the adrenal glands after exposure to a stressful event. These effects occur through activation of mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs). The molecular mechanisms that underlie the effects of glucocorticoids on synaptic transmission, synaptic plasticity, learning and memory have recently begun to be identified. Glucocorticoids regulate AMPA (α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate) receptor trafficking--which is crucially involved in synaptic transmission and plasticity--both rapidly and persistently. Stress hormones may, through modulation of AMPA receptor function, promote the consolidation of behaviourally relevant information.


Assuntos
Corticosteroides/metabolismo , Memória/fisiologia , Plasticidade Neuronal/fisiologia , Receptores de AMPA/metabolismo , Estresse Fisiológico/fisiologia , Animais , Receptores de Glucocorticoides/metabolismo , Receptores de Mineralocorticoides/metabolismo
6.
Artigo em Inglês | MEDLINE | ID: mdl-21423510

RESUMO

Exposure of an organism to environmental challenges activates two hormonal systems that help the organism to adapt. As part of this adaptational process, brain processes are changed such that appropriate behavioral strategies are selected that allow optimal performance at the short term, while relevant information is stored for the future. Over the past years it has become evident that chronic uncontrollable and unpredictable stress also exerts profound effects on structure and function of limbic neurons, but the impact of chronic stress is not a mere accumulation of repeated episodes of acute stress exposure. Dendritic trees are reduced in some regions but expanded in others, and cells are generally exposed to a higher calcium load upon depolarization. Synaptic strengthening is largely impaired. Neurotransmitter responses are also changed, e.g., responses to serotonin. We here discuss: (a) the main cellular effects after chronic stress with emphasis on the hippocampus, (b) how such effects could contribute to the development of psychopathology in genetically vulnerable individuals, and (c) their normalization by brief treatment with anti-glucocorticoids.

7.
Brain Res ; 1293: 91-100, 2009 Oct 13.
Artigo em Inglês | MEDLINE | ID: mdl-19332034

RESUMO

After stress, circulating levels of stress hormones such as corticosterone are markedly increased. This will have an impact on the neurophysiology of limbic neurons that highly express corticosteroid receptors. Over the past decades several principles about the neurophysiological impact of corticosterone have emerged. First, corticosterone can quickly raise the excitability of hippocampal CA1 neurons shortly after stress exposure, via a nongenomic pathway involving mineralocorticoid receptors presumably located in the pre- as well as postsynaptic membrane. At the same time, gene-mediated actions via the glucocorticoid receptor are started which some hours later will result in enhanced calcium influx and impaired ability to induce long-term potentiation. These delayed actions are interpreted as a means to slowly normalize hippocampal activity and preserve information encoded early on after stress. Second, the full spectrum of neurophysiological actions by corticosterone is accomplished in interaction with other stress mediators, like noradrenaline. Third, these effects in the CA1 hippocampal region cannot be generalized to other brain regions such as the basolateral amygdala or paraventricular nucleus: There seems to be a highly differentiated response, which could serve to facilitate neuroendocrine/cognitive processing of some aspects of stress-related information, but attenuate other aspects. Finally, the time- and region-specific corticosteroid actions strongly depend on the individual's life history.


Assuntos
Corticosterona/fisiologia , Sistema Límbico/fisiopatologia , Neurônios/fisiologia , Transmissão Sináptica/fisiologia , Animais , Norepinefrina/fisiologia , Receptores de Glucocorticoides/fisiologia , Receptores de Mineralocorticoides/fisiologia , Fatores de Tempo
8.
PLoS One ; 4(3): e4714, 2009.
Artigo em Inglês | MEDLINE | ID: mdl-19305644

RESUMO

BACKGROUND: The stress hormone corticosterone has the ability both to enhance and suppress synaptic plasticity and learning and memory processes. However, until today there is very little known about the molecular mechanism that underlies the bidirectional effects of stress and corticosteroid hormones on synaptic efficacy and learning and memory processes. In this study we investigate the relationship between corticosterone and AMPA receptors which play a critical role in activity-dependent plasticity and hippocampal-dependent learning. METHODOLOGY/PRINCIPAL FINDINGS: Using immunocytochemistry and live cell imaging techniques we show that corticosterone selectively increases surface expression of the AMPAR subunit GluR2 in primary hippocampal cultures via a glucocorticoid receptor and protein synthesis dependent mechanism. In agreement, we report that corticosterone also dramatically increases the fraction of surface expressed GluR2 that undergo lateral diffusion. Furthermore, our data indicate that corticosterone facilitates NMDAR-invoked endocytosis of both synaptic and extra-synaptic GluR2 under conditions that weaken synaptic transmission. CONCLUSION/SIGNIFICANCE: Our results reveal that corticosterone increases mobile GluR2 containing AMPARs. The enhanced lateral diffusion properties can both facilitate the recruitment of AMPARs but under appropriate conditions facilitate the loss of synaptic AMPARs (LTD). These actions may underlie both the facilitating and suppressive effects of corticosteroid hormones on synaptic plasticity and learning and memory and suggest that these hormones accentuate synaptic efficacy.


Assuntos
Anti-Inflamatórios/farmacologia , Corticosterona/farmacologia , Plasticidade Neuronal/efeitos dos fármacos , Receptores de AMPA/metabolismo , Transmissão Sináptica/efeitos dos fármacos , Complexo 2 de Proteínas Adaptadoras/metabolismo , Animais , Eletrofisiologia , Endocitose/efeitos dos fármacos , Recuperação de Fluorescência Após Fotodegradação , Hipocampo/citologia , Hipocampo/fisiologia , N-Metilaspartato/metabolismo , Neurônios/citologia , Neurônios/efeitos dos fármacos , Neurônios/metabolismo , Ratos , Receptores de Glucocorticoides/metabolismo
9.
Artigo em Inglês | MEDLINE | ID: mdl-21423408

RESUMO

Humans and rodents retain memories for stressful events very well. The facilitated retention of these memories is normally very useful. However, in susceptible individuals a variety of pathological conditions may develop in which memories related to stressful events remain inappropriately present, such as in post-traumatic stress disorder. The memory enhancing effects of stress are mediated by hormones, such as norepinephrine and glucocorticoids which are released during stressful experiences. Here we review recently identified molecular mechanisms that underlie the effects of stress hormones on synaptic efficacy and learning and memory. We discuss AMPA receptors as major target for stress hormones and describe a model in which norepinephrine and glucocorticoids are able to strengthen and prolong different phases of stressful memories.

10.
Front Neuroendocrinol ; 28(2-3): 72-96, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-17544065

RESUMO

In normal life, organisms are repeatedly exposed to brief periods of stress, most of which can be controlled and adequately dealt with. The presently available data indicate that such brief periods of stress have little influence on the shape of neurons or adult neurogenesis, yet change the physiological function of cells in two time-domains. Shortly after stress excitability in limbic areas is rapidly enhanced, but also in brainstem neurons which produce catecholamines; collectively, during this phase the stress hormones promote focused attention, alertness, vigilance and the initial steps in encoding of information linked to the event. Later on, when the hormone concentrations are back to their pre-stress level, gene-mediated actions by corticosteroids reverse and normalize the enhanced excitability, an adaptive response meant to curtail defense reactions against stressors and to enable further storage of relevant information. When stress is experienced repetitively in an uncontrollable and unpredictable manner, a cascade of processes in brain is started which eventually leads to profound, region-specific alterations in dendrite and spine morphology, to suppression of adult neurogenesis and to inappropriate functional responses to a brief stress exposure including a sensitized activation phase and inadequate normalization of brain activity. Although various compounds can effectively prevent these cellular changes by chronic stress, the exact mechanism by which the effects are accomplished is poorly understood. One of the challenges for future research is to link the cellular changes seen in animal models for chronic stress to behavioral effects and to understand the risks they can impose on humans for the precipitation of stress-related disorders.


Assuntos
Neurônios , Estresse Fisiológico , Adaptação Biológica , Corticosteroides/metabolismo , Animais , Encéfalo/anatomia & histologia , Encéfalo/fisiologia , Forma Celular , Doença Crônica , Modelos Animais de Doenças , Humanos , Potenciação de Longa Duração/fisiologia , Neurônios/citologia , Neurônios/fisiologia , Estresse Fisiológico/patologia , Estresse Fisiológico/fisiopatologia , Estresse Fisiológico/prevenção & controle
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