[Possibilities of Holter ECG monitoring in detecting arrhythmia and myocardial ischemia in persons with ischemic heart disease risk factors]. / Vozmozhnosti kholterovskogo monitorirovaniia EKG v vyiavlenii narushenii ritma i ishemii miokarda u lits s faktorami riska ishemicheskoi bolezni serdtsa.

Holter's ECG monitoring was used to investigate 140 males showing no clinical signs of coronary disease, while having 1 to 5 coronary risk factors (hypodynamia, arterial hypertension, smoking, hypercholesterolemia). Supraventricular rhythm disorders were recorded in 86%, and ventricular ones, in 69%. Transitory ST depression was detected in 15% of the cases, appearing in response to physical (90%) of mental (9%) stress or spontaneously in 1%. Ninety percent of ischemic attacks were asymptomatic. Ischemic ECG changes were nearly twice as frequent in patients with 3 to 5 coronary risk factors, as compared to those with 1 or 2 risk factors. It is therefore suggested that asymptomatic coronary disease can be suspected in some of the patients with coronary risk factors. This suspicion is confirmed by positive bicycle ergometric test in 53% of the individuals with changed Holter's ECG monitoring data. Combined use of Holter's ECG monitoring and bicycle ergometry increases twofold the detectability of electrocardiographic abnormalities.

[Moderate arterial hypertension during its natural course and in drug correction]. / Umerennaia arterial'naia gipertoniia pri estestvennom techenii i medikamentoznoi korrektsii.

The clinical and morbid anatomy data on 295 patients with arterial hypertension were examined. Two hundred patients had moderate hypertension with the diastolic pressure under 110 mm Hg. Of these, 103 patients had received rauwolfia drugs and 13 patients had been given hypothiazide in addition. Eighty patients who died before 1953 had not received any specific hypotensive drugs. Early hypotensive therapy of moderate hypertension was noted to promote a decrease in arterial blood pressure to normal and to raise the mean lifespan by 8 years. Furthermore the number of fatal brain strokes and myocardial infarctions decreased almost 2-fold.