[State of hypophyseal thyrotropic function in the complex treatment of thyroid cancer]. / Sostoianie tireotropnoi funktsii gipofiza pri kompleksnom lechenii raka shchitovidnoi zhelezy.

Radioimmune assay of the hypophyseal thyreotropic hormone (THH) in blood of 89 patients with thyroid cancer in stage II and III indicated that the THH level prior to the treatment did not differ from that in healthy individuals--3,0 +/- 0,6 ng/ml. Subtotal thyroidectomy was associated with a sharp riste of the thyreotropin concentration in blood during the immediately 7--20 days after surgery followed by its normalization in 1--2 months. Immediately after distant gamma-therapy the THH concentration did not differ from the initial value, but in later terms it was dependent on the clinical patient's state i.e. under hypothyreosis it was increased. Increased THH level was also noted in development of the cancer recurrence following the applied therapy (without hypothyreosis).

[The influence of effective treatment of diabetes mellitus and obesity on the plasma concentration of immunoreactive insulin]. / Vliianie éffektivnogo lecheniia sakharnogo diabeta i ozhireniia na soderzhanie immunoreaktivnogo insulina v plazme krovi

A study was made of 16 patients with the initial mild form of diabetes mellitus in whom the immunoreactive insulin (IRI) indices in glucose loading pointed to a good reactivity of the beta-cells of the insular apparatus of the pancreas. As a result of the dietetic treatment or therapy with saccharolytic oral preparations diabetes proved to become compensated but the IRI indices were unchanged. In patients with adiposity there was seen an increase in the concentration of blood IRI and a reduction of the reaction of beta-cells to the administration of glucose. A course of treatment by dosaged starvation (a loss of weight by an average of 11.5 kg) caused no improvement in the IRI indices was less pronounced, and the treatment by diet with limited caloric value led to improvement of the IRI indices.