[State of the adrenergic and cholinergic systems of schizophrenic patients during the process of psychopharmacotherapy]. / Sostoianie adrenergicheskoi i kholinergicheskoi sistem u bol'nykh shizofreniei v protsesse psikhofarmakoterapii.

The state of catecholamine and acetylcholine metabolism in schizophrenic patients with recurrent, attacklike-progressive and continuous forms was studied during the process of neuroleptical treatment. The level of doses, duration of administration and the dynamics of the mental state were taken into consideration. It was established that in schizophrenic patients the correlation of the studied system compared to the control group is changed. The study demonstrated different types of changes in catecholamine metabolism in patients with different forms of the schizophrenic process, prior to and during psychopharmacotherapy. The obtained results permitted to give some recommendations in the therapeutic approaches in schizophrenic patients with attack-like and continuous forms of the disease.

[Neurochemical aspects of corrective effect of fluoracizine in triphthazine-induced catalepsy in rats]. / Neirokhimicheskie aspekty korrektornogo deistviia ftoratsizina pri triftazinovoi katalepsii u krys.

Following introduction of triftazine (2 mg/kg) and phthoracizine 8 mg/kg, separately and in combination, the intensity of catalepsy, the content of dopamine, norepinephrine (fluorometrically), of acetylcholine (biologically) and the activity of cholinesterase (calorimetrically) in the caudate nuclei and the frontal part of the cortex were determined in rats. It was established that with its one-time administration phthoracizine, while keeping down the intensity of triftazine-induced catalepsy, prevents, at the same time, the development of a number of biochemical effects, viz. there appears a distinctly pronounced tendency toward mormalization of the dopamine, acetylcholine levels and of the cholinesterase activity. A multiple joint administration of the drugs is also attended by lowering the intensity of catalepsy. Then, biochemical changes manifest themselves in more complex interrelations.

[The role of catecholamines, acetylcholine and cholinesterase activity in the development of the cataleptic action of triftazin following repeated administration]. / Rol' katekholaminov, atsetilkholina i aktivnosti kholinésterazy v razvitii katalepticheskogo deistviia triftazina pri ego mnogokratnom vvedenii

Catalepsy occurring in rats in a singular and repeated introduction of triftasine has a manifold mechanism, the main components of which are related to the metabolism of dophamine, acetylcholine and cholinesterase activity. A change in the intensity of catalepsy in a multiple introduction of the preparation is due mainly to cholinergic influences.