[The effect of lithium oxybutyrate on the development of the fetus and progeny in alcoholic intoxication of male rats]. / Vliianie litiia oksibutirata na razvitie ploda i potomstva v usloviiakh alkogol'noi intoksikatsii samtsov krys.

The effect of lithium hydroxybutyrate on the development of the fetus and offsprings was studied on a model of alcohol intoxication of male rats. Under such conditions lithium hydroxybutyrate relieved completely the negative action of alcohol on the reproductive function, according to all parameters. The learning ability of the offsprings and their behavioral disorders in a stress situation caused by alcohol were normalized. Two-week administration of 100 mg/kg lithium hydroxybutyrate had no negative effect on the embryonal and postnatal development of the offsprings.

[The nooglutil correction of functional disorders of the central nervous system caused by prenatal alcoholization in rats]. / Korrektsiia noogliutilom narushenii funktsii tsentral'noi nervnoi sistemy, vyzvannykh prenatal'noi alkogolizatsiei u krys.

Administration of ethanol (5 g/kg/day, per os) to the pregnant rats evoked delayed impairments of the learning and memory in the offspring. Prenatal alcoholization of the animals attenuated the habituation of the exploration behavior in open field, impaired acquisition and retention of active avoidance in a shuttle box, increased slow activity of the EEG spectrum power, disturbed the function of the serotoninergic system in the brain cortex and of the dopaminergic system in the hippocamp. The new nootropic drug nooglutyl (N-5/hydroxynicotinoyl/-L-glutamic acid) administered in a dose of 25 mg/kg/day from the 8th to the 20th day of life prevented the above-mentioned delayed disturbances of higher integrative functions and biochemical processes in rat brain.

[The lithium oxybutyrate correction of disorders in higher nervous activity in the progeny of alcoholized male rats]. / Korrektsiia litiia oksibutiratom narushenii vysshei nervnoi deiatel'nosti potomstva alkogolizirovannykh krys-samtsov.

In experiments on rats it was shown that alcohol administered intragastrically in a dose of 8 g/kg for 4 weeks produced long-term disturbances of CNS function in the offspring similar to those observed under clinical conditions. Early postnatal administration of lithium oxybutyrate (from the 8th through the 14th day of life) was found to prevent the development of the disturbances.

[Effect of teturam on the development of the offspring of alcoholized animals]. / Vliianie teturama na razvitie potomstva alkogolizirovannykh zhivotnykh.

During experiments on rats it was found that in alcoholized animals teturam on the whole did not potentiate and in some cases even attenuated the toxic effect of alcohol on the offspring development. The data confirm the idea about necessity of studying toxicity of drugs under the conditions corresponding to their clinical use.

[Effect of alcohol and teturam on the gonads of male rats and their progeny]. / Vliianie alkogolia i teurama na gonady samtsov krys i ikh potomstva.

Experiments on rats were made to study the effect of alcohol and teturam on the function of spermatozoa and spermatogenesis of males and their progeny. The male-mediated damaging action of alcohol on the gonads of the progeny was ascertained. That might be one of the causes of the maldevelopment in subsequent generations of the progeny. Teturam was demonstrated to have an insignificant gonadotropic action and not to potentiate an adverse alcohol action on the male gonads.

[Chronic alcoholic intoxication in animals as a model for the study of the safety of new anti-alcohol agents]. / Khronicheskaia alkogol'naia intoksikatsiia u zhivotnykh kak model' dlia izucheniia bezopasnosti novykh protivoalkogol'nykh sredstv.

Experiments on 200 noninbred male rats have demonstrated that daily administration of ethanol per os in a dose of 8 g/kg (2/3 LD50) for a month produced pathological changes in organs and systems of the body, which were similar to the manifestations of chronic alcoholic intoxication in man. It is concluded that the model under consideration may be used during preclinical study of the safety of new antialcoholic agents.

[Effect of phenazepam on the body organs and systems of rats subjected to prolonged ethanol exposure]. / Vliianie fenazepama na sostoianie organov i sistem organizma krys, podvergnutykh dlitel'nomu vozdeistviiu étanola.

Experiments made on 80 randombred male rats have demonstrated that the tranquilizer phenazepam in a daily dose of 1 mg/kg administered per os to intact animals for 14 days produces no adverse changes in the hematological, biochemical and morphological indicators that characterize the status of the most important organs and systems of the body. Administration of phenazepam to rats preexposed to ethanol (4 g/kg per os once a day for a month) has been found to retard the elimination of morphological alterations in the liver and brain induced by ethanol. The results obtained allow recommending the use of appropriate experimental models in the preclinical study of the safety of new antialcoholic agents.