RESUMO
It was shown that carnosine changes the compacting of ferment's globe. On the one hand, that action is causes with the connecting of haem. On the other hand, carnosine influences on the hydrate's membrane around protein. Dipeptide influences also on the interaction of catalase with sodium nitrite, which intensity depends on sequence of introducing HNO2 and carnosine into the medium.
Assuntos
Carnosina/farmacologia , Catalase/metabolismo , Nitrito de Sódio/metabolismo , Antioxidantes/metabolismo , Radicais Livres , Penicillium/enzimologia , EspectrofotometriaRESUMO
This article shows that in oxygen transported and antioxidative systems considerable changes take place during dynamic of adaptation to oxygen deficiency of inhaled air (every day 4 hours stay of animals in barochamber under pO2 7.45 kPa during 12 days). Single influence of hypoxic factor induced in erythrocytes peripheral blood increasing of haemoglobin affinity to oxygen, decreasing SOD and catalase activity on the background of increasing of malon aldehyde level. On 12-th day of adaptation of animals contents of TBA-active products in erythrocytes is saved on high level, activity of antioxidative enzymes is approached to original meanings, haemoglobin affinity to oxygen is decreased in comparison with control. Detected increasing content of creatine in erythrocytes during dynamic of rat adaptation to hypoxic hypoxia witnessed about erythropoiesis activation and quickened exit out of marrow young forms of erythrocytes.