[Effect of a new sweetening agent from Stevia rebaudiana on animals]. / Vliianie novogo podslastitelia iz dvulistnika sladkogo na organizm zhivotnykh.

Animals received saccharol adequate (by sweetness) to sugar, and in 10- and 50-fold increased amounts. The data of chronic 10-month experiments studied in the time course after 2, 5, 10 months have permitted a conclusion that saccharol included into the ration during long periods, does not produce a significant effect on the parameters of metabolic processes and morphological picture of the internal organs in test animals. Saccharol in 50-fold increased amounts inhibits the activity of oxidative phosphorylation in the hepatic tissue of rats.

[Effect of the total replacement of fats in the diet with a phospholipid concentrate on oxidative phosphorylation in liver mitochondria and the lipid composition of the plasma and liver in rats]. / Vliianie polnoi zameny zhirov v ratsione fosfolipidnym kontsentratom na okislitel'noe fosforilirovanie v mitokhondriiakh pecheni i lipidnyi sostav plazmy i pecheni u krys.

Experimental rats were given rations with 100% substitution of fats for phospholipid concentrate, during 1 and 3 months. It was found that such rations produced hypolipidemic and hypocholesterolemic effects, that were most pronounced at the end of the experiment. A control ration with sunflower oil containing high levels of unsaturated fatty acids induced accumulation of lipid peroxides in the hepatic tissue and blood plasma of the animals fed with the ration during 3 months. The ration containing the phospholipid concentrate did not produce such an effect. The data obtained have evidenced a positive influence of the phospholipid concentrate on the lipid metabolism parameters studied.

[Effect of the meat of farm animals fed new nitrogen-containing food additives on the morphologic features of the internal organs in the rat]. / Vliianie miasa sel'skokhoziaistvennykh zhivotnykh, poluchavshikh novye azotsoderzhashchie kormovye dobavki, na morfologicheskie osobennosti vnutrennikh organov krys.

A study was made of the internal organs of rats fed the meat of agricultural animals whose diet included non-protein nitrogen-containing compounds--urea, isobutylidene diurea and a polymer, carbamide with polyacrylamide. Morphological studies have demonstrated that inclusion into the diet of experimental rats of the meat of young bulls given isobutylidene diurea and urea leads to structural alterations in the internal organs of rats, the most pronounced alterations being detected in experiments with the use of the meat of young bulls given isobutylidene diurea. The feeding of experimental rats with the meat of animals grown with the use of the polymer did not affect the morphofunctional status of their organs.

[Light and electron microscopic data on the characteristics of the utiliztion of amikin and aminozol, preparations for parenteral feeding]. / Osobennosti utilizatsii preparatov dlia parenteral'nogo pitaniia amikina i aminozola po dannym svetovoi i élektronnoi mikroskopii.

It has been extablished that in the course of protein starvation in dogs, parenteral administration of amikin or aminozol normalizes, to a greater of less extent, the disturbed metabolism of proteins, nucleoproteins, glycogen and lipids. Electron microscopy has shown that the ingredients of the preparations enter the cells at an equal intensity from the microcirculatory bed by means of active transendothelial transport. In the course of utilization of the substances supplied to the cells, no marked changes were seen in protein synthesis or in its participation in intracellular reparative regeneration. There occurs a pronounced cytosegresomal response to unutilized substances accumulated by hepatocytes. The clinical efficacy of the preparations used is related to the processes of gluconeognesis of amino acids supplied as a result of which energy formation does not require structural or endogenously formed protein.

[Morphological changes in the liver due to the parenteral administration of casein hydrolysate and aminopeptide]. / Morfologicheskie izmeneniia pecheni pri parenteral'nom vvedenii gidrolizata kazeina i aminopeptida.

In experiments set up on 30 mongrel rats kept for 10 days on a protein-free diet the influence of an intraperitoneal introduction of caseine hydrolysate or aminopeptide on the morphological structure of the liver was studied. It was found that introduction to rats of aminopeptide or caseine hydrolysate caused stabilization of morphological changes in the liver produced by protein fasting. However, with aminopeptide introduced after protein fasting positive morphological changes proved greater than with an analogous utilization of caseine hydrolysate.