RESUMO
At the end of 36 years after the Chernobyl disaster, about 5 million people still live in the radioactively contaminated territories of Russia, Ukraine, and Belarus, and the density of radioactive contamination by Cesium-137 and Strontium-90 will remain radiologically significant for decades. We assessed cervical and endometrial cancer primary incidence (new cases) in the female population from the Bryansk region living in conditions of chemical, radioactive, and combined environmental contamination for 2000−2020. We found a significant increase in the long-term trend in the primary incidence of cervical and endometrial cancer in all the studied groups, regardless of the environmental conditions of residence (p < 0.00001). We did not find statistically significant differences in the incidence of cervical and endometrial cancer in women, regardless of the level of chemical, radioactive, and combined environmental contamination. However, women living in environmentally unfavorable areas (in total, in the territories of chemical, radioactive, and combined contamination) are statistically significantly more likely to develop endometrial cancer in terms of relative risk compared to environmentally safe (control) areas (RR 1.17 (1.08−1.27)). No such pattern was found for cervix cancer. It should be noted, since environmentally safe (control) areas have a certain level of contamination (albeit low), RR is underestimated.
RESUMO
A three-component reaction involving in situ generation of propargylureas and subsequent Zn(OTf)2-mediated cyclocondensation with a primary amine yielded trisubstituted 2-aminoimidazoles. These findings are in contrast to the previously reported base-promoted unimolecular cyclization of propargylureas (leading to 2-imidazolones) and extend the range of Lewis acid-catalyzed azole syntheses based on N-carbonyl propargylamines.