[Effect of hemodialysis on digoxin pharmacokinetics in heart failure in patients with chronic kidney failure]. / Vliianie gemodializa na farmakokinetiku digoksina pri serdechnoi nedostatochnosti u bol'nykh s khronicheskoi pochechnoi nedostatochnost'iu.

The authors have estimated the effect of hemodialysis on the pharmacokinetics of digoxin instilled intravenously to patients with the terminal stage of chronic renal insufficiency. It has been shown that dialysis was associated with an almost double increase in the clearance constant of digoxin due to its additional elimination through the membrane of the dialyzer. Over five h of dialysis the body excretes 12.5% of the administered dose of digoxin which is only 3.8% more (by 19 micrograms) than the average amount eliminated without dialysis. The contribution of dialysis to the elimination of digoxin is insignificant and, therefore, the regimen of its administration on days when dialysis is performed should be left unchanged.

[Treatment of blood coagulation disorders in patients with chronic renal insufficiency]. / Lechenie narushenii svertyvaniia krovi u bol'nykh s khronicheskoi pochechnoi nedostatochnost'iu.

Intravascular blood coagulation has been shown to play the leading role in the development of hemostatic disorders with reference to 34 patients with chronic renal failure. The data are provided about high efficacy of heparin therapy with low doses in combination with fresh-frozen plasma transfusions for thrombohemorrhagic complications in this patient group.