Glaucoma classification based on scanning laser ophthalmoscopic images using a deep learning ensemble method.

This study aimed to assess the utility of optic nerve head (onh) en-face images, captured with scanning laser ophthalmoscopy (slo) during standard optical coherence tomography (oct) imaging of the posterior segment, and demonstrate the potential of deep learning (dl) ensemble method that operates in a low data regime to differentiate glaucoma patients from healthy controls. The two groups of subjects were initially categorized based on a range of clinical tests including measurements of intraocular pressure, visual fields, oct derived retinal nerve fiber layer (rnfl) thickness and dilated stereoscopic examination of onh. 227 slo images of 227 subjects (105 glaucoma patients and 122 controls) were used. A new task-specific convolutional neural network architecture was developed for slo image-based classification. To benchmark the results of the proposed method, a range of classifiers were tested including five machine learning methods to classify glaucoma based on rnfl thickness-a well-known biomarker in glaucoma diagnostics, ensemble classifier based on inception v3 architecture, and classifiers based on features extracted from the image. The study shows that cross-validation dl ensemble based on slo images achieved a good discrimination performance with up to 0.962 of balanced accuracy, outperforming all of the other tested classifiers.

Application of Imbalanced Data Classification Quality Metrics as Weighting Methods of the Ensemble Data Stream Classification Algorithms.

In the era of a large number of tools and applications that constantly produce massive amounts of data, their processing and proper classification is becoming both increasingly hard and important. This task is hindered by changing the distribution of data over time, called the concept drift, and the emergence of a problem of disproportion between classes-such as in the detection of network attacks or fraud detection problems. In the following work, we propose methods to modify existing stream processing solutions-Accuracy Weighted Ensemble (AWE) and Accuracy Updated Ensemble (AUE), which have demonstrated their effectiveness in adapting to time-varying class distribution. The introduced changes are aimed at increasing their quality on binary classification of imbalanced data. The proposed modifications contain the inclusion of aggregate metrics, such as F1-score, G-mean and balanced accuracy score in calculation of the member classifiers weights, which affects their composition and final prediction. Moreover, the impact of data sampling on the algorithm's effectiveness was also checked. Complex experiments were conducted to define the most promising modification type, as well as to compare proposed methods with existing solutions. Experimental evaluation shows an improvement in the quality of classification compared to the underlying algorithms and other solutions for processing imbalanced data streams.