RESUMO
T1 and T2 relaxation times were measured in ten brain regions on the right and left side in a sample of 27 schizophrenic patients and 37 normal controls. The schizophrenic patients showed a prolongation of T2 relaxation time, and to a lesser extent of T1 relaxation time, which was more predominantly localized in the right hemisphere and in gray matter structures. These results may indicate that metabolic, physiological, or neurochemical brain function in schizophrenia is related in some way to a change in tissue fluid in neuronal cell bodies or interstitial gray matter.
Assuntos
Encéfalo/patologia , Imageamento por Ressonância Magnética , Transtornos Neurocognitivos/patologia , Transtornos Neurocognitivos/psicologia , Esquizofrenia/patologia , Psicologia do Esquizofrênico , Adulto , Mapeamento Encefálico , Dominância Cerebral/fisiologia , Espaço Extracelular/fisiologia , Feminino , Humanos , Líquido Intracelular/fisiologia , Masculino , Transtornos Neurocognitivos/diagnóstico , Esquizofrenia/diagnósticoRESUMO
To investigate clinical pharmacokinetics of lithium carbonate, 28 hospitalized mental patients and 8 healthy volunteers were studied. The serum concentration/time profile in the single dose peroral experiments could be fitted to a pharmacokinetic model using an open two compartmental system. Three methods, 72-h and 24-h residual method and Ritschel's repeated one-point method were used and the results compared with one another. According to the results of this paper, we suggest the use of Ritschel's repeated one-point method for clinical dosage regimen determination.
