Swept-Source Optical Coherence Tomography Thresholds in Differentiating Clinical Outcomes in a Real-World Cohort of Treatment-Naïve Multiple Sclerosis Patients.

This study aimed to determine whether peripapillary retinal nerve fiber layer (pRNFL) and ganglion cell-inner plexiform layer (GCIPL) thickness thresholds for single-time-point swept-source optical coherence tomography (SS-OCT) measures can differentiate the clinical outcomes of treatment-naïve people with multiple sclerosis (pwMS). A total of 275 patients with the clinically isolated syndrome (n = 23), benign MS (n = 8), relapsing-remitting MS (n = 185), secondary progressive MS (n = 28), primary progressive MS (n = 31), and with no history of optic neuritis were included. The mean Expanded Disability Status Scale (EDSS) score was 3.0 ± 1.6. The cut-off values of pRNFL (87 µm and 88 µm) and GCIPL (70 µm) thicknesses have been adopted from previous studies using spectral-domain OCT. PwMS with pRNFL ≤87 µm and ≤88 µm had a longer disease duration, more advanced disability, and more frequently progressive MS variants compared to those with greater pRNFL thicknesses. In distinguishing pwMS with disability greater than or equal to the mean EDSS score (EDSS ≥ 3) from those with less severe disability, GCIPL thickness <70 µm had the highest sensitivity, while pRNFL thickness ≤87 µm had the greatest specificity. The optimal cut-off values differentiating patients with EDSS ≥ 3 from those with less severe disability was 63 µm for GCIPL thickness and 93.5 µm for pRNFL thickness. In conclusion, pRNFL and GCIPL thickness thresholds for single-time-point SS-OCT measurements may be helpful in differentiating the disability status of treatment-naïve pwMS.

Spectral-Domain Optical Coherence Tomography Assessment in Treatment-Naïve Patients with Clinically Isolated Syndrome and Different Multiple Sclerosis Types: Findings and Relationship with the Disability Status.

This study evaluates the peripapillary retinal nerve fiber layer (pRNFL) thickness and total macular volume (TMV) using spectral-domain optical coherence tomography in treatment naïve patients with the clinically isolated syndrome (CIS) and different multiple sclerosis (MS) types. A total of 126 patients (15 CIS, 65 relapsing-remitting MS, 14 secondary progressive MS, 11 primary progressive MS, 21 benign MS) with or without optic neuritis (ON) history and 63 healthy age-similar controls were assessed. Concerning controls' eyes, pRNFL thickness was significantly reduced in CIS-ON eyes (p < 0.01), while both TMV and pRNFL thickness was decreased in all MS eyes regardless of ON history (p < 0.01). Significant differences in pRNFL thickness and TMV between MS variants were observed for non-ON eyes (p < 0.01), with the lowest values in benign and secondary progressive disease type, respectively. The pRNFL thickness was inversely correlated with Expanded Disability Status Scale (EDSS) score in non-ON subgroups (p < 0.01), whereas TMV was inversely correlated with EDSS score in both ON and non-ON subgroups (p < 0.01). Concluding, pRNFL thinning confirms optic nerve damage in CIS-ON eyes and appears to be disproportionately high with respect to the disability status of benign MS patients. The values of TMV and pRNFL in non-ON eyes significantly correspond to MS course heterogeneity and patients' disability than in ON eyes.

New insights into the socio-economic aspects of multiple sclerosis in a cohort of Polish patients.

INTRODUCTION AND OBJECTIVE: The diagnosis of multiple sclerosis (MS) affects the socio-economic aspects of patients' lives and poses new challenges. The objectives of the study were: 1) to determine selected socio-economic aspects of MS in Poland in relation to the disease type and patients' place of residence, and 2) to evaluate the profile of patients via the MS Society (MSS) and the occupational consequences of informing an employer about the diagnosis. MATERIAL AND METHODS: A retrospective, observational study was undertaken to assess a cohort of 375 Polish MS patients. Socio-economic data was collected based on the patients' responses to questions on a questionnaire. Clinical data was obtained from available medical records. RESULTS: Patients with relapsing-remitting MS had a significantly longer time of occupational activity, higher economic status, higher level of education, better relationships with life partner, less likely to benefit from disability benefits, and members of MSS, than patients with progressive types of the disease. The patients living in rural areas had a significantly shorter time of occupational activity, more often experienced a decrease in income, received disability pension, and were less educated than urban residents. Patients who informed their employer about an MS diagnosis significantly more often received support from the company, were professionally active for longer, and less likely to experience a decrease in income. Membership of the MSS were dominated by patients with progressive variants of the disease and advanced disability. CONCLUSIONS: The disease variant and, to a lesser extent, the place of residence, affected the socio-economic aspects of MS. It might be advantageous for the patient to disclose information about MS diagnosis to the employer.

Optical coherence tomography in diagnosis and monitoring multiple sclerosis.

This paper presents application of optical coherence tomography (OCT) for diagnosis and monitoring of multiple sclerosis (MS). The peripapillary retinal nerve fibre layer thinning and the reduced total macular volume analysis are shown. With the course of the MS, the severity of these abnormalities increases which reflects the progressive degeneration of retinal ganglion cells and nerve fibres. The OCT parameters are sensitive, non-invasive indicators useful in assessing the progression of inflammation and neurodegeneration in MS.

[Idiopathic juxtafoveolar teleangiectasia 2a in spectral domain optical coherence tomography (SdOCT)]. / Idiopatyczne teleangiektazje okolodoleczkowe typu 2a w obrazie spektralnej optycznej koherentnej tomografii (SOCT).

PURPOSE: The aim of the study was the evaluation of the changes characteristic for type 2a idiopathic juxtafoveal retinal telangiectasia in spectral domain optical coherence tomography images. MATERIAL AND METHODS: The study covered 23 eyes with diagnosed idiopathic juxtafoveal retinal telangiectasia of type 2a - 5 men and 7 women. Stage 2 was noticed in 9 eyes, stage 3 in 5 eyes, stage 4 in 8 eyes. Stage 5 was noticed in one eye. All the patients included in the study underwent the macula analysis by SdOCT technique. RESULTS: Stage 2 was characterized mainly by the occurrence of small hyporeflective microcysts (in 100% of cases), tiny hyperreflective deposits (in 90% of patients), focal retinal photoreceptor layer damage (in 80%) as well as large hyporeflective cysts (70%). Stage 3 in SdOCT scans showed dominating hyperreflective deposits, including both small ones (100%) and less frequent large shaded deposits (71%), and still numerous microcysts (86%) and larger hyporeflective compartments. Stage 4 was characterized by the occurrence of large spreaded areas of fading retinal photoreceptor layer (in 100% of examined eyes), accompanied by retina architecture disorders. We also noticed numerous tiny hyperreflective deposits (100% of examined eyes), as well as large hyperreflective deposits (80%). Microcysts occurred significantly less frequently than in other stages (60%). The average retina thickness in fovea in all eyes irrespective of the stage of disease amounted to 192.13 +/- 59.1 microm, on the other hand in the nasal and temporal parts of fovea 202.43 +/- 37.75 microm and 262.7 +/- 41.31 microm respectively (p< 0.05). CONCLUSIONS: Thanks to its high resolution, SdOCT examination depicts changes in retina in the course of idiopathic juxtafoveal telangiectasia in great detail. Our study shows certain permanent changes occurring in this disease, characteristic to subsequent stages which allow to make a highly probable diagnosis before fluorescein angiography is carried out.