[AGE-RELATED ASPECTS OF THE DEVELOPMENT OF ABNORMAL UTERINE BLEEDING IN GIRLS OF DIFFERENT SOMATOTYPES].

Violation of the formation of menstrual function in adolescent girls of the puberty is a widespread phenomenon, that is greatly affected with age-related aspects. Since the factors affecting the body will be forming the anthropometric and somatotypological indicators of the body of girls differently, it is therefore advisable to divide them according to narrow age categories: 12-14 years, 14-15 years. And 16-18 years old. 288 adolescent females were examined, 58 of which with abnormal uterine bleeding were included in the main group, 230 actually healthy girls of the same age were included in the comparison group. General clinical, ultrasound, laboratory, anthropometric, somatotypological and statistical research methods were used. Analysis of the data obtained was carried out using the program "STATISTICA 5.5" using non-parametric methods for evaluating the results. The aim: to predict the development of abnormal uterine bleeding using discriminant function, according to the age categories. Anthropometric, somatotypological and statistical research methods. After examination of girls of different age categories, we obtained results according to which for girls aged 14-15 in predicting the AUB pathognomonic indicators were Mateyko body mass fat component according to Mateyko, transverse lower pit size, circumference of the chest in a state of rest and in a state of maximum exhale, the distal epiphysis of the forearm, the ectomorphic component of the Mateyko according to Heath-Carter, the width of the distal epiphysis of the hip and the external conjugate. Girls of 16-18 years old have relevant indicators such as transverse lower pit size, body mass fat component according to Mateyko, chest circumference in a state of maximum exhale, thickness of the skin-fat fold under the shoulder, on the chest, on the abdomen and side, the width of the distal epiphysis of the femur. Thus, we have characterized the patterns of the occurrence of abnormal uterine bleeding for girls 14-15 y. and 16-18 y.e respectively.

PECULIARITIES OF CYTOKINE RESPONSE IN CHILDREN WITH SHIGELLOSIS AND CONCOMITANT CYTOMEGALOVIRUS INFECTION.

The article presents the results of a comparative analysis of the level of interleukins of children with Shigellosis in different periods of the disease depending on the presents of CMV-infection in patients. To achieve the goal, 63 children aged from three to eight years old with Shigellosis were examined, who were treated at the Regional Children's Infectious Clinical Hospital of Kharkiv, Ukraine. It has been established that the presence of CMV in patients with Shigellosis leads to the development of cytokine imbalance which persists until the period of early convalescence. In the acute period of Shigellosis in children with CMV infection, the level of IL-1ß significantly increases with unreliable fluctuations in the indices of TNF-α and IL-4. In children with Shigellosis without comorbidities, an increase in the level of all cytokines is recorded. In children with monoinfection to the period of convalescence, a significant dynamics of decrease in the levels of all interleukins was observed with their indicators approaching the physiological norm. In case of Shigellosis in children with CMV, the content of IL-1ß and IL-4 was still significantly high. Violation of the normalization of the cytokine profile of patients with Shigellosis on the background of CMV infection may be one of the leading factors in the torpid clinical recovery, the formation of an unfavorable course of the disease. In our opinion, these features of the cytokine response of patients must be considered during the period of rehabilitation and follow-up.

PREDICTING OF RISKS OF GROUNDWATER AND SURFACE WATER POLLUTION WITH DIFFERENT CLASSES OF HERBICIDES IN SOIL IN EASTERN EUROPE CLIMATE CONDITIONS.

Application of pesticides in modern agriculture is a powerful permanent risk factor for public health and the natural environment. The aim of the study was a comparative hygienic assessment of the danger of contamination of ground and surface water sources with most widely used herbicides of different chemical classes (sulfonylureas, imidazolinones, pirimidinilkarboksilovye compounds semicarbazones). Field hygienic experiments for studying of the residues dynamics of studied herbicides concentration in agrocenosis objects were made by us in different types of soils: chernozem, sod-podzolic, podzolized forest. Then the half-life periods (DT50) of the substances in the soil were calculated. It was found that according to GUS index there is a high probability of leaching into groundwater of sulfonylureas and imidazolinones; according to LEACH index all investigated substances have a high risk of run-off into groundwater and surface water.

[PREDICTING OF RISK OF SOIL CONTAMINATION BY DIFFERENT CLASSES OF FUNGICIDES IN SOIL AND CLIMATIC CONDITIONS OF UKRAINE].

Application of pesticides in modern agriculture is a powerful permanent risk factor for public health and the natural environment. The aim of the study was a comparative hygienic assessment of soil pollution hazards by the most widely used herbicides of different chemical classes (sulfonylureas, imidazolinones, pyrimidinyl (thio) benzoates, semicarbazones). Hygienic field experiment for studying of the dynamics of residual amounts of the test substances in the soil under different climatic zones of Ukraine was conducted. Half life periods (DT50) or herbicides in soil were calculated using the method of mathematical modeling. Ecotoxicological risk of herbicides on ecosystems and ecological communities was determined. It was established that bispyribac-sodium (pyrimidinyl (thio) benzoates) and imidazolinones are persist the longest time in soil and most rapidly degradable is diflufenzopyr (semicarbazone); ecotoxicological risk of the studied herbicides for terrestrial biocenoses of Ukraine by 4-6 orders of magnitude lower than dihlordifeniltrihlormetilmetan (DDT).

[MODERN MEANS FOR THE TREATMENT OF ATRIAL FIBRILLATION IN DIABETIC PATIENTS].

The authors discuss modern approaches to the treatment of atrial fibrillation with reference to diabetic patients. The studies carried out thus far showed the importance of differential anti-arrhythmic therapy taking account of the clinical form of ciliary arrhythmia. The possibility of surgical and preventive treatment (up-stream therapy) is demonstrated.

[The efficacy of prolonged-action nitrates in stenocardia]. / Effektivnost' nitratov prolongirovannogo deistviia pri stenokardii.

The therapeutic efficacy and changes of clinical and hemodynamic indices due to the use of long-action nitrates were studied in 91 patients with chronic ischemic heart disease. The native drug nitrogranulong produces an essential effect on the hemodynamics resulting in a complete disappearance or reduction of stenocardia attacks, increased tolerance to physical loads as evidenced by bicycle ergometric data.