Service needs of families where one parent has an affective illness: implications for service, education, and policy.

This study explored the service needs of families with a parent with an affective illness. Focus-group and individual interviews were conducted at selected locations across Canada with individuals who had an affective disorder, their partners, and their adult children. A total of 67 participants were recruited. Corresponding service providers were mailed a questionnaire which asked information regarding these families' needs, the service provider's role with these families, and what prevented or assisted them in addressing those needs. A total of 419 service providers participated in the study. There was congruence between family-identified needs and the needs identified by service providers. However, there remains a large disparity between the knowledge of needs and having these needs met. The results of this study identify the gaps in service provision and make recommendations for changes in the areas of service, education, and policy-making.

Women's experiences breastfeeding in public places.

This two-part field study compared researchers' recorded observations to mothers' perceptions of attention they received while publicly breastfeeding. In part 1, four breastfeeding and four bottle-feeding mothers each made eight restaurant visits. On average, there were more neutral looks from customers (P = .01) during breastfeeding visits, but no differences in the amount of overtly negative or positive attention given during breastfeeding versus bottle feeding. In part 2, four breastfeeding mothers made a total of 24 visits to shopping malls. There were more neutral looks given while mothers were breastfeeding and more smiles and comments while they were not feeding, but no difference in total amount of attention received. Breastfeeding mothers acknowledged they had anticipated some undesirable attention but instead received little attention. Nevertheless, they felt "vulnerable" nursing in public. Certain proactive behaviors and personal attributes as well as support from other women enabled them to breastfeed successfully in public.

New directions in analyses of parenting contributions to children's acquisition of values.

Traditional theories of how children acquire values or standards of behavior have emphasized the importance of specific parenting techniques or styles and have acknowledged the importance of a responsive parent-child relationship, but they have failed to differentiate among forms of responsiveness, have stressed internalization of values as the desired outcome, and have limited their scope to a small set of parenting strategies or methods. This paper outlines new directions for research. It acknowledges the central importance of parents and argues for research that (1) demonstrates that parental understanding of a particular child's characteristics and situation rather than use of specific strategies or styles is the mark of effective parenting; (2) traces the differential impact of varieties of parent responsiveness; (3) assesses the conditions surrounding the fact that parents have goals other than internalization when socializing their children, and evaluates the impact of that fact; and (4) considers a wider range of parenting strategies.

Function and content of maternal demands: developmental significance of early demands for competent action.

The sources and effects of mothers' demands upon children were examined during naturalistic interactions of 70 mothers and their 1 1/2-3 1/2-year-olds. Demands were categorized in terms of immediate function (e.g., do's vs. don'ts) and content area emphasized by mothers (e.g., competent action, appropriate behavior, caretaking). Children's age and oppositional behavior influenced the nature of mothers' demands. Mothers with authoritative child-rearing attitudes emphasized proactive, competence-oriented demands and avoided regulatory controls. Maternal demands for competent action (prosocial behavior, chores, cognitive/play) predicted enhanced compliance and fewer behavior problems at age 5. Demands focused on the regulation of personal and social behavior predicted more behavior problems at age 5. We propose that children's personal and social competence emerges from pressures for instrumentally competent behavior in a harmonious interactive context.

Maternal autonomy granting: predictors of normal and depressed mothers' compliance and noncompliance with the requests of five-year-olds.

Maternal compliance and noncompliance to child requests, thought to represent an autonomy-granting aspect of socialization, were studied in 24 well mothers and 26 mothers with a history of depression and their 5-year-old children. Mothers continued to retain substantially more power than children in the control process. There were no differences between normal and depressed mothers in the extent to which they granted or denied their children's requests, but the determinants of maternal autonomy granting differed in the 2 groups. Depressed, but not well, mothers' responses to child requests could be predicted from their self-reported mood prior to the interaction and from the concurrent child's behavior. Depressed mothers who reported negative mood and whose children were uncooperative most often denied their requests. Depressed mothers' noncompliance to their children's requests was determined by the quantity rather than quality of their children's behavior: they did not discriminate between skillful and unskillful forms of the children's autonomy expressions.

Impact of diagnosed depression and self-reported mood on mothers' control strategies: a longitudinal study.

Control strategies of 70 well and depressed mothers were assessed twice: when their children were of toddler age (Time 1) and, for 39 of the mothers, when their children were 5 (Time 2). At Time 1 well mothers were more direct with their children, using more direct commands and reprimands, and fewer explanations than depressed mothers. At Time 2 well mothers used fewer direct commands than depressed mothers. Self-reported negative mood preceding the interaction in well mothers was associated with decreased directness at Time 1 but increased directness at Time 2. At Time 1 depressed mothers' negative mood was associated with a decrease in the use of explanations. All mothers used more unclear commands and fewer reprimands and positive incentives with their 5-year-olds than when the children were toddlers. Depressed mothers, but not well mothers, increased their use of direct commands when the children were older. The findings are interpreted in the context of complex interplay between mother's diagnosis of depression, self-reported mood preceding the interaction, and the developmental level of the child.

Correspondence between mothers' self-reported and observed child-rearing practices.

The correspondence between self-reported child-rearing attitudes and practices and actual child management was examined among 68 mothers of young children. Data on mothers' verbal and physical control techniques along with children's responses (cooperation vs. resistance) were obtained during 90 min of spontaneous interaction in a naturalistic setting. Self-report data (the Block Q-Sort) were obtained 1-2 weeks later. The Block Q-Sort factors were combined to represent authoritarian and authoritative patterns of attitudes. The authoritarian pattern was positively associated with the use of direct commands, physical enforcements, reprimands, and prohibitive interventions, and negatively associated with the use of suggestions. The authoritative pattern was positively related to the use of suggestions and positive incentives, and negatively related to the use of physical enforcements, prohibitive interventions, and direct commands. Mothers' enjoyment of the parental role and their negative affect toward the child, as expressed in the Block Q-Sort, were more a result of the child's cooperation/resistance during the interaction than predictors of maternal control strategies.

Resolutions of control episodes between well and affectively ill mothers and their young children.

Control interactions between 87 well and affectively ill mothers and their 15- to 51-month-old children were studied. Spontaneously occurring control interventions (conceptualized as episodes of interaction between mother and child) were coded from 90 minutes of videotaped interactions in a naturalistic laboratory apartment setting. The results suggest developmental changes in mother-child interaction in the 2nd to 4th years of life: the increase of the rate of immediate maternal success (p less than .05) and compromise (p less than .05), on the decrease in maternal use of power (ultimate success by enforcement, p less than .01). Well mothers achieved compromise with their children, particularly daughters, more often than did affectively ill mothers (p less than .05). Affectively ill mothers more often than well mothers avoided confrontation with their children (p less than .05). The impairments in control interventions of affectively ill mothers were exacerbated by the severity of the disorder.

Patterns of attachment in two- and three-year-olds in normal families and families with parental depression.

Patterns of attachment were examined in normal and depressed mothers. Mother's diagnosis (bipolar, major unipolar, or minor depression, or no psychiatric disorder), self-reported current mood states, and affective behavior in interaction with the child were considered. A modified version of Ainsworth and Wittig's Strange Situation was used to assess attachment. Insecure (A, C, and A/C patterns) attachments were more common among children of mothers with a major depression (bipolar or unipolar) than among children of mothers with minor depression or among children of normal mothers. Insecure attachment was more frequent in children of mothers with bipolar depression than in children of mothers with unipolar depression. A/C attachments were associated with histories of most severe depression in the mother. In families in which mothers were depressed, depression in the father did not increase the likelihood of anxious attachment between mother and child. However, if mothers with a major affective disorder were without a husband in the household, risk of an insecure mother-child attachment was significantly increased. The mothers' expressed emotions (positive vs. negative) in interaction with their children in situations other than the Strange Situation, and independent of diagnosis, predicted patterns of attachment: mothers of insecurely attached children expressed more negative and less positive emotion. Mothers' self-reports of moods on the days they were observed were unrelated to attachment. Results are discussed in terms of the transmission of social and emotional disorders in relation to mothers' affective functioning.

Synthesis of new 4 and 5 disubstituted isothiazoles.

Synthesis of 24 new 4 and 5 substituted isothiazole derivatives, containing hydrazine and amino groups at the position 5, and carboxyl, ester, amide, hydrazide, nitrile or ureido group in the position 4 is described. Compounds 4, 6, 8 and 19 show antiinflammatory activity, compound 14 has antiaggregatory properties.

Chemical and biological properties of 2-pyridyl-benzyl-carbinol.

Three isomers of pyridylbenzylcarbinol were synthetized and their chemical properties and biological activity were studied. Clear dependence between chemical structure and antitumor activity was observed. As expected most active appeared 2-pyridylbenzylcarbinol (alpha-carbinol). It showed significant antitumor activity against subcutaneous tumors of Ehrlich carcinoma. Nemeth-Kellner lymphoma and sarcoma 180. On a chronic treatment schedule tumor inhibition from 60 to 80% was induced. No activity was seen in L1210 and P388 models. In B16 melanoma the significant inhibition of tumor growth was obtained at 200 mg/kg/injection. Tumor inhibitory effect was also observed in Yoshida sarcoma. Depending on a dose and schedule the increase in lifespan from 45 to 147% was achieved. LD50 and MTD were determined and were 750 +/- 87.65 mg/kg and 557.8 mg/kg, respectively. Only slight suppressive effect of alpha-carbinol on immunological system was showed. It concerned mainly immunological reactions with cellular system involved, in which distinct suppressive effects were noted. Specific and nonspecific humoral reactivity was little or not at all affected by alpha-carbinol.

Synthesis and biological properties of pyrazo-[3,4-B]-pyridine derivatives. II.

By aminoalkylation with diethylaminoethyl chloride of 3-hydroxypyrazo-[3,4-b]-pyridine 1 and its phenyl derivative 2 as well as 3-aminopyrazo-[3,4-b]-pyridine 7 and its phenyl derivative 8, basic ethers 5, 6 and aminoalkanoloamines 9 and 10 have been obtained. Compounds 5, 6 and 10 increased coronary blood flow of the isolated cat heart. At the concentration of 5 +/- 2 mg/ml shoved spasmolytic activity.

Synthesis and biological activity of pyrazo-[3,4-b]-pyridine derivatives. Part I.

3 (3'-Morpholino-2'-hydroxypropoxy)--7--9 as well as 3 (3'-morpholino-2'-hydroxypropyloamino) 14 -- 16 derivatives of 1-methyl and 1-phenyl pyrazo-[3,4-b]-pyridines were prepared and screened for expected circulatory activity. Compounds 7, 11--14, 20 mg/kg, produced hypotension in cats; Compounds 7 and 14, 50--80 mg/kg, had antiarrhytmic action in BaCl2 -- induced arrhytmic in the rabbit.

Anaesthesia for operation of traumatic heart tamponade. A case report.

The authors report a case of myocardial stab wound followed by shock and symptoms of heart tamponade. Following a discussion on the haemodynamic aspects of this disease entity and description of the case the authors analize the most essential elements of general anaesthesia in such conditions.

Synthesis and pharmacological properties of new pyridine derivatives.2,6-bis-[diphenyl-(and dibenzyl)-hydroxymethyl]-piperidines.

Syntheses of 2,6-bis-(diphenylhydroxymethyl)-, 2,6-bis-(dibenzylhydroxymethyl)- and 2,6-bis-(phenylbenzylhydroxymethyl)-pyridines were carried out. These compound were hydrogenated to the corresponding piperidine carbinols. The compounds are of low toxicity and were tested on mice for their CNS activity, using climbing test. 2,6-bis-(dibenzylhydroxymethyl)-piperidine (VI) exhibited central depressive activity.