RESUMO
Wistar rats were used in the study. 15 male rats were exposed to Xe:O2(80:20) mixture for 2 hours twice a week during 10 weeks, and 60 female rats were affected similarly for 2 weeks. The three groups have been formed: 1st group consists of 15 exposed males joined by 30 control female rats, 2nd group includes 30 exposed female rats and 15 control male rats, 15 control male rats and 30 control female rats were in the 3rd group. Xe:O2(80:20) inhalation affect neither fertility and pregnancy indices, which reached 90%, nor body mass gain during pregnancy, nor pre- and postimplantation embryonal death, neonatal body mass and development. Xenon does not impair fine mechanisms of reproductive function, being most safe gas anesthetic with nice prospects for applying in obstetrical clinics.
Assuntos
Anestésicos Inalatórios/toxicidade , Peso ao Nascer/efeitos dos fármacos , Reprodução/efeitos dos fármacos , Xenônio/toxicidade , Animais , Feminino , Reabsorção do Feto/induzido quimicamente , Tamanho da Ninhada de Vivíparos/efeitos dos fármacos , Masculino , Exposição Materna/efeitos adversos , Exposição Paterna/efeitos adversos , Gravidez , Ratos , Ratos WistarRESUMO
30 Wistar rats inhaled a Xe (80%):O2(20%) mixture for 2 hours twice a week on the 1st to 19th days of pregnancy. On the 20th day of pregnancy 70% rats were exposed to euthanasia, the rest of animals were left for labors to study the postnatal course in the progeny. Inhaling the Xe (80%):O2(20%) mixture did not affect either the changes in body mass of pregnant rats, indices of postimplantating loss of embryos and pregnancy duration or the number of live newborns, their body mass and sizes. Xenon caused neither inhibition of osteal system development nor any malformations. The results of study permit one to look optimistically at the prospects for using Xenon in obstetrical anesthesiology.
