[Physical criteria of pathological processes. I. Change in the functional hemispheric asymmetry at various stages of rheumatic diseases]. / Fizicheskie kriterii patologicheskikh protsessov. I.Izmenenie funktsional'noi mezhpolusharnoi asimmetrii na raznykh stadiiakh revmaticheskikh zabolevanii.

The functional interhemispheric asymmetry of brain in patients with systemic rheumatic diseases was estimated by measuring brain direct current potentials. It is shown that different types of functional interhemispheric asymmetry correspond to different stages of systemic rheumatic diseases. At early stages, the left hemisphere asymmetry dominates, at expressed stages, the right hemisphere asymmetry is prevalent, and the terminal stage is characterized by the loss of functional interhemispheric asymmetry.

[Activity of the autoimmune process during systemic rheumatic diseases and distribution of constant brain potential]. / Aktivnost' autoimmunnogo protsessa pri sistemnykh revmaticheskikh zabolevaniiakh i raspredelenie postoiannogo potentsiala golovnogo mozga.

The data obtained upon examination of patients with systemic rheumatic diseases were analyzed by the methods of multiple regression and step-by-step discriminant analysis. Is was shown that the activity of autoimmune process correlates with the parameters of distribution of constant potential level in the brain of each patient, irrespective of diagnosis. The scatter of potential values was the most important predictor of activity. An increase in the activity of the autoimmune process correlated with a decrease in the scatter of potential values at recording points; the cerebral cortex became equipotential.

[Constant brain potentials as neurophysiological markers of autoimmune process]. / Postoiannye potentsialy golovnogo mozga kak neirofiziologicheskie markery autoimmunnogo protsessa.

Neuroimmune interactions in systemic rheumatic diseases were studied. The state of the central nervous system was assessed from the parameters of constant brain potentials, and the state of the immune system, from a complex of immunobiochemical parameters. The highest multiple correlation coefficients were revealed between the immunobiochemical parameters and the parameters of the constant brain potential, which characterize linear and standard deviations of potentials in temporal zones from potentials at other points of recording. The results are discussed in terms of structural and functional integration of the immune and nervous systems.

[Physical criteria of pathological processes. III. Structure of the correlation between the level of steady brain potential with serum complement proteins in rheumatic diseases]. / Fizicheskie kriterii patologicheskikh protsessov. III. Struktura korreliatsionnoi urovnia postoiannogo potentsiala golovnogo mozga s belkami syvorotochnogo komplementa pri revmaticheskikh zabolevaniiakh.

The activity of serum complement proteins and the level of steady brain potential in patients with systemic lupus erythematosus and rheumatoid arthritis were determined. The statistical analysis indicated that there is a correlation between the parameters of the complement system and neurophysiological characteristics. The differences between rheumatoid arthritis and systemic lupus erythematosus are observed in the mean values of activity of complement proteins and the steady potential, their dispersions, and the structure of correlations between immunological and neurophysiological parameters.

[Physical criteria of pathological processes. II. Modulating role of functional interhemisphere asymmetry in forming and immune response in rheumatic diseases]. / Fizicheskie kriterii patologicheskikh protsessov. II. Moduliruiushchaia rol' funktsional'noi mezhpolusharnoi asimmetrii v formirovanii immunnogo otveta pri revmaticheskikh zabolevaniiakh.

The level of the brain permanent potential as a physiological criterion of the functional interhemisphere asymmetry, as well as immunological and biochemical characteristics of peripheral blood in patients with systemic rheumatic diseases were studied. It was found that the distribution of the characteristics of immune response in patients with different types of interhemisphere asymmetry. Significant differences were observed for average values of biochemical and immunological characteristics, their dispersions, as well as for the structure of relationships between the type of the interhemisphere asymmetry and immunobiochemical characteristics.