RESUMO
Objective To explore the relationship between the angiotensin-converting enzyme(ACE) gene inserton/deletion(I/D) polymorphism and the cardiorespiratory fitness. Methods One hundred twenty six male subjects were recruited and randomized into a physical exercise(n=65) or a control group(n=61).The men in the physical exercise group were trained with mild-moderate intensity physical exercise for 5 years. The men in the control group were advised to make their personal choice whether or not to engage in physical exercise. The cardiorespiratory fitness indices,e.g. aerobic threshold were measured at baseline and annually. The I/D polymorphism in the 16 th intron of ACE gene was analysed by polymerase chain reaction. Results At baseline, the aerobic threshold was (14.4 ? 3.9)ml?min -1?kg -1 in the physical exercise group. After 5-year physical exercise, the aerobic threshold was (16.4 ? 4.1)ml?min -1?kg -1in the physical exercise group. At baseline, the aerobic thresholds was(14.2 ?3.6)ml?min -1?kg -1in the control group. After 5 years, the aerobic threshold was(13.8 ? 3.3)ml?min -1?kg -1in the control group. After 5 year physical exercise, compared with the baseline and the control group, the aerobic threshold increased significantly in the physical exercise group(both,P0.05). Conclusions Regular low to moderate intensity physical exercise can increase aerobic threshold and improve cardiorespiratory fitness. Compared with the subjects with the ACE DD genotypes, the cardiorespiratory fitness can be improved more easily for the subjects with the ACE II,ID genotypes.
RESUMO
We investigated the role of the angiotensinogen (AGT) gene M235T polymorphism in determining blood pressure (BP) response to moderate intensity exercise in a 6-yr randomized controlled trial in 140 middle-aged men. Sitting, supine, and standing blood pressures were measured annually. Of the randomized men, 86% participated in the trial for 6 yr. Submaximal cardiorespiratory fitness increased by 16% in the exercise group. In the M homozygotes, sitting systolic BP decreased by 1.0 mmHg in the exercise but increased by 14.6 mmHg in the reference group (P = 0.007 for net effect). Sitting and supine diastolic BP decreased by 6.2 and 3.3 mmHg in the exercise but increased by 2.8 and 3.2 mmHg in the reference group (P = 0.026 and 0.024 for net effects), respectively. Regular moderate intensity exercise attenuates aging-related increase in systolic BP and decreases diastolic BP among the M homozygotes of the AGT gene M235T polymorphism.
