Measurement of the index of refraction of the plastic Phenoxy PKFE.

The index of refraction, n of Phenoxy PKFE, a light yellow plastic produced by Union Carbide, is measured at lambda = 588 nm (n(D)), lambda = 656 nm (n(C)), and lambda = 486 nm (n(F)). These values are of interest because they must be known to determine the optical characteristics of a Phenoxy PKFE lens over the visible spectrum. Lenses made of Phenoxy PKFE have an important advantage over lenses made of other plastics. Phenoxy PKFE is chemically resistant to many epoxy glues commonly used to form airtight bonds in hermetically sealed chambers.

Studies of the antitumor activity of (2-alkoxyalkyl)- and (2-alkoxyalkenyl)phosphocholines.

Analogues of the synthetic antitumor phospholipid ALP (1-octadecyl-2-methyl-sn-glycero-3-phosphocholine; alkyl lysophospholipid) in which the 1-ether oxygen atom has been removed have been prepared and evaluated for in vitro and in vivo anticancer activity. Compounds are presented in which the saturated long chain varies in length from 8 to 25 carbon atoms. Sites of unsaturation are also incorporated into the framework in some examples. In particular, rac-(2-ethoxyeicosyl)phosphocholine (10) displays the best in vivo activity of the chemical series against a variety of transplanted tumors and activates murine peritoneal macrophages to express tumor cytotoxicity in vitro. However, 10 does not offer the wide spectrum of antitumor activity we feel necessary to warrant further study.