Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 4 de 4
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Front Immunol ; 12: 696268, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34413849

RESUMO

Context: Disseminated infections due to Mycobacterium bovis Bacillus Calmette-Guérin (BCG) are unusual and occur mostly in patients with inborn error of immunity (IEI) or acquired immunodeficiency. However, cases of secondary BCGosis due to intravesical BCG instillation have been described. Herein, we present a case of severe BCGosis occurring in an unusual situation. Case Description: We report one case of severe disseminated BCG disease occurring after hematological malignancy in a 48-year-old man without BCG instillation and previously vaccinated in infancy with no complication. Laboratory investigations demonstrated that he was not affected by any known or candidate gene of IEI or intrinsic cellular defect involving IFNγ pathway. Whole genome sequencing of the BCG strain showed that it was most closely related to the M. bovis BCG Tice strain, suggesting an unexpected relationship between the secondary immunodeficiency of the patient and the acquired BCG infection. Conclusion: This case highlights the fact that, in addition to the IEI, physicians, as well as microbiologists and pharmacists should be aware of possible acquired disseminated BCG disease in secondary immunocompromised patients treated in centers that administrate BCG for bladder cancers.


Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Neoplasias Hematológicas/tratamento farmacológico , Reconstituição Imune , Hospedeiro Imunocomprometido , Mycobacterium bovis/patogenicidade , Infecções Oportunistas/microbiologia , Tuberculose Pulmonar/microbiologia , Administração Intravesical , Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Antituberculosos/uso terapêutico , Vacina BCG/administração & dosagem , Vacina BCG/efeitos adversos , Interações Hospedeiro-Patógeno , Humanos , Masculino , Pessoa de Meia-Idade , Mycobacterium bovis/efeitos dos fármacos , Mycobacterium bovis/imunologia , Infecções Oportunistas/tratamento farmacológico , Infecções Oportunistas/imunologia , Fatores de Risco , Resultado do Tratamento , Tuberculose Pulmonar/diagnóstico , Tuberculose Pulmonar/tratamento farmacológico , Tuberculose Pulmonar/imunologia , Neoplasias da Bexiga Urinária/tratamento farmacológico , Neoplasias da Bexiga Urinária/imunologia
2.
Artigo em Inglês | MEDLINE | ID: mdl-32788393

RESUMO

OBJECTIVE: To report the association of JC virus infection of the brain (progressive multifocal encephalopathy [PML]) during the course of sarcoidosis and the challenging balance between immune reconstitution under targeted cytokine interleukin 7 (IL7) therapy for PML and immunosuppression for sarcoidosis. METHODS: Original case report including deep sequencing (whole-exome sequencing) to exclude a primary immunodeficiency (PID) and review of the literature of cases of PML and sarcoidosis. RESULTS: We report and discuss here a challenging case of immune reconstitution with IL7 therapy for PML in sarcoidosis in a patient without evidence for underling PID or previous immunosuppressive therapy. CONCLUSIONS: New targeted therapies in immunology and infectiology open the doors of more specific and more specialized therapies for patients with immunodeficiencies, autoimmune diseases, or cancers. However, before instauration of these treatments, the risk of immune reconstitution inflammatory syndrome and potential exacerbation of an underlying disease must be considered. It is particularly true in case of autoimmune disease such as sarcoidosis or lupus.


Assuntos
Síndrome Inflamatória da Reconstituição Imune/diagnóstico , Interleucina-7/farmacologia , Leucoencefalopatia Multifocal Progressiva/tratamento farmacológico , Sarcoidose/diagnóstico , Humanos , Interleucina-7/administração & dosagem , Interleucina-7/efeitos adversos , Masculino , Pessoa de Meia-Idade , Sequenciamento do Exoma
4.
J Med Microbiol ; 59(Pt 11): 1375-1378, 2010 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-20651040

RESUMO

Chronic meningococcaemia is an unusual clinical presentation of Neisseria meningitidis infection. We describe the case of a patient, who presented with total IgA deficiency and partial IgM deficiency with a low switched memory B cells count, suggestive of a borderline form of common variable immunodeficiency (CVID). The role of IgA in the protection against Neisseria meningitidis, and the link between IgA deficiency and CVID are discussed.


Assuntos
Bacteriemia/complicações , Bacteriemia/diagnóstico , Imunodeficiência de Variável Comum/complicações , Imunodeficiência de Variável Comum/diagnóstico , Infecções Meningocócicas/complicações , Infecções Meningocócicas/diagnóstico , Neisseria meningitidis/isolamento & purificação , Bacteriemia/microbiologia , Exantema/etiologia , Exantema/patologia , Feminino , Humanos , Imunoglobulina A/imunologia , Infecções Meningocócicas/microbiologia , Adulto Jovem
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...