[Immediate and late follow-up results of surgical and combined treatment of patients with colonic cancer of various localization in right half of the colon].

Comparative estimation of immediate and late follow-up results of treatment was con- ducted in 520 patients, suffering cancer of the colonic right half, including coecum - in 227 (43.7% ± 2.1%), colon ascendum - in 159(30.7% ± 2.0%), right colonic flexure - in 66 (12.9% ± 1.3%), right half of colon transversum - in 66 (12.9% ± 4.2%). In 463 (89.0% ± 1.4%) patients radical operations were performed, while in 57 (11.0% ± 1.7%) - the symptomatic. After radical operations 8 (1.7% ± 0.5%) patients died, and after the symptomatic - 3 (5.3% ± 3.0%). Definite surgical treatment was performed in 258 (60,8% ± 2,4%) patients, the combined one - in 166 (39.2% ± 2.4%). Five-year survival have constituted (64.2% ± 5.5%) for the patients, operated on for the colon ascendumcancer, and (19.1% ± 5.7%) - for cancer of right colonic flexure; while after combined treatment - (40.4% ± 5.8%) in patients, operated on for cancer of coecum, (29.4% ± 11.9%) - right half of colon transversum; ten-year survival have constituted (16.8% ± 2.7%) for the patients, who were radically operated for cancer of coecum, and (4.8% ± 2.6%) - for cancer of right colonic flexure (p<0,005). Late follow-up results of radical treatment of the colonic right half depends essentially on localization and degree of the cancer spread.

[The clinico-genetic characteristics of the origin and manifestation of colorectal cancer]. / Kliniko-henetychni osoblyvosti vynnyknennia ta manifestatsiï kolorektal'noho raku.

A clinical and genealogical investigation has been carried out in 169 subjects of both sexes, presenting with colorectal oncopathology. Particular features of the colorectal carcinoma in the patients have been recognized. The frequency of the tumours spread in the relatives of the probands is determined as is the spectrum of aggregation of large intestine carcinoma with neoplasia of other genesis in the pedigrees. The data obtained suggest an important contribution of genetic factors into the origination of colorectal carcinoma.