1.
Bioorg Med Chem Lett
; 10(11): 1265-7, 2000 Jun 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10866396
RESUMO
A series of oxa-spermidine derivatives and homologues were prepared and their anticancer properties were evaluated. All these compounds showed an average GI50 value in the range of 3.9-28.9 microM. SAR studies showed that the presence of a sulphonamido functionality and the length of the alkyl chain are important factors for an enhanced activity.
