[The effect of withdrawal from L-DOPA compounds on pathochemical changes of motor structures of the brain caused by them]. / Vliianie otmeny preparatov L-DOFA na vyzvannye imi patokhimicheskie izmeneniia dvigatel'nykh struktur mozga.

Activities of enzymes of protein metabolism (aminopeptidase, acid phosphatase), of neurotransmitters (monoamine oxidase, acetylcholinesterase) and oxidative metabolism (glutamate- and glucose-6-phosphate dehydrogenases) were studied by quantitative cytochemical procedures in brain motor structures (sensomotor cortex, caudate nucleus) as well as in brain tissues not related directly to locomotory functions (n. accumbens, hippocampus) of rats exhibiting high and low locomotory activities after repeated L-DOPA administration within 14 days as well as within 14 days after drug discontinuation. That of L-dopa (madopare) caused alterations in the enzymatic activity in the brain motor structures of rats, mainly, with a high locomotory activity. It may be suggested that madopare withdrawal-induced decreases in MAO activity might be, to a certain extent, a cause of dyskinesias occurring after discontinuation of L-DOPA drugs.

[Pathochemical changes in the motor structures of the brain under the influence of the administration of L-DOPA preparations and their withdrawal (experimental research)]. / Patokhimicheskie izmeneniia dvigatel'nykh struktur mozga pod vliianiem vvedeniia preparatov L-DOFA i ikh otmeny (éksperimental'noe issledovanie).

In the course of a long-term L-DOPA administration (14 days) and 2 weeks after its cessation the activities of some protein enzymes (aminopeptidase, acid phosphatase), neuromediator (MAO, ACE) and oxidative (glutamate dehydrogenase, glucose-6-phosphate dehydrogenase) metabolism were studied by quantitative cytochemical methods in brain motor structures (sensorimotor cortex, caudate nucleus) and in structures not directly related to motor functions (hippocampus) of rats with high and low motor activity. After L-DOPA (madapar) cessation significant changes were revealed in the formation of motor system of the brain, primarily in the group of rats with low motor activity. It is suggested that a decrease in MAO activity after madapar cessation may be responsible for dyskinesia arising after cessation of L-DOPA preparations treatment.

[The study of V. I. Lenin's brain]. / Issledovanie mozga V. I. Lenina.

The investigation of V. I. Lenin's brain was carried out on the basis of study of 1108 cytoarchitectonical slices (thickness of 20 mu), stained by Kresil-Violett (Nissl's method) and 558 slices of fibres stained by Geidenhain's method. This is the first in the history of science detailed microscopical study of the man brain, initiated to creation of russian architectonics (as a science of the brain architecture); this study was served for a foundation of structural basis of science on the brain individual variability of different people including prominent persons. The results of this study is compared with a data of the later macroscopic and microscopic investigation of many persons brain with different professions and abilities. The next peculiarities of the Lenin's brain have been written: 1. The relief complexity and peculiarities of sulci and gyri configuration, especially in frontal lobe. 2. The big percentage of the cortex in a deep of the sulci (so called intrasulcal component), and as a result of the increasing of the summarised size of the cortex cerebri. 3. The riches and pronunciation of s.c. limitrophic adaptation's zones between different areas, especially in the frontal lobe and in the other associative cortical structures. 4. The originality in relation in size between area in one region and regarding to the whole cortex surface. The prevail of the size and variability of phylogenetically new (associative) regions, especially of frontal one (which takes part in the function of situation estimation, prognostication, generalization) and also of parietal and temporal cortex; the phylogenetically old zone are more stable. 5. The large number of the especially big pyramidal neurons in sublayer III (III(3)), that can be supposedly looked as a structural basis of the rich associative connections between different cortical regions. The above mentioned peculiarities have been done as a result of the study chiefly of the right brain hemisphere because the left one was seriously suffered as a result of the vessels damage of atherosclerosis origin.

[Structural basis of the cortical regulation of movement]. / O strukturnykh osnovakh korkovykh reguliatsii dvizhenii.

The author analyzes his own and literature data about a wide-scale presentation of motor functions in the cerebral cortex, about the structure of sensomotor area, overlapping of the cortical zones of movements and sensitivity, efferent supraspinal motor routes and subcortical motor formations of the brain at different levels and some aspects of the cortical regulation of the structures in health and disease. The concept of analyzers seems to be a promising approach to studies of the motor regulation system, particularly to generalization of the findings obtained heretofore; the structure of the cortical end of the motor analyzer is described.

Effect of afferent visual impulses on morphological and biochemical indices of the development of neurons of the optical, motor, and parietal cortex of the brain.

We have demonstrated cytochemically that absence of visual impulsation from the time of birth causes two types of reconstruction in the cerebral structures. The first type is associated with reactions of a biochemical deficiency (in the optic and parietal cortex), the second with reactions of biochemical activation (in the motor cortex). We established that the changed organization of the metabolic processes is reversible provided that specific impulsation is resumed. This reconstruction is most complex for compensatorily activated neurons, and less complex for neurons showing signs of biochemical deficiency.