1.
Nat Methods
; 13(12): 993-996, 2016 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27798610
RESUMO
A robust method for simultaneous visualization of all four cell cycle phases in living cells is highly desirable. We developed an intensiometric reporter of the transition from S to G2 phase and engineered a far-red fluorescent protein, mMaroon1, to visualize chromatin condensation in mitosis. We combined these new reporters with the previously described Fucci system to create Fucci4, a set of four orthogonal fluorescent indicators that together resolve all cell cycle phases.