A randomized, controlled study of Kan Jang versus amantadine in the treatment of influenza in Volgograd.

Two randomized, parallel-group clinical studies with a verum and a control group were performed to investigate the effect of a standardized extract (SHA-10) of Andrographis panaiculata (N.) fixed combination Kan Jang in the treatment of diagnosed influenza viral infection. The pilot study was performed on 540 patients with 71 Kan Jang-treated patients with the second phase conducted enrolling 66 patients. The differences in the duration of sick leave and frequency of post-influenza complications indicate that the Kan Jang phytopreparation not only contributes to quicker recovery, but also reduces the risk of post-influenza complications. Kan Jang was well tolerated by patients.

[Evaluation of the adequacy of hypotensive therapy based on the status of the tissue oxygen system and serum lactate dehydrogenase and cytochrome oxidase activities in patients with hypertension]. / Otsenka adekvatnosti gipotenzivnoi terapii po sostoianiiu kislorodnogo rezhima tkanei i aktivnosti laktatdegidrogenazy i tsitokhromoksidazy v syvorotke krovi u bol'nykh gipertonicheskoi bolezn'iu.

Parameters of tissue oxygen regime measured by polarography and serum lactate dehydrogenase (LDG) and cytochrome oxidase (CO), oxidation-reduction enzymes, were studied in 23 patients with stable hypertension of various hemodynamic types. The nature of the tissue oxygen regime and changes observed in the isoenzymic spectra of LDG and CO were found to be associated with BP levels, hemodynamic types and BP reduction degree. The time course of these values may be useful in assessing whether the antihypertensive therapy is appropriate and in determining an optimal level of BP decrease.

[Criteria for assessing the adequacy of a hypotensive effect by data on the lactate dehydrogenase and cytochrome oxidase isoenzyme spectra of patients with different forms of arterial hypertension]. / O kriteriiakh otsenki adekvatnosti gipotenzivnogo éffekta po dannym izofermentnogo spektra laktatdegidrogenazy i tsitokhromoksidazy u bol'nykh s razlichnymi formami arterial'noi gipertenzii.

A study of associations between lactate dehydrogenase and cytochrome oxidase isoenzymes and total cytochrome oxidase activity, on the one hand, and the type of arterial hypertension, the magnitude of blood pressure and its response to treatment, on the other, was carried out in 143 patients with varying stages of essential hypertension and in renal hypertension. The examined parameters were found to be valuable indicators of adequate hypotensive effect and an optimum BP fall. A 20-24% BP drop below the baseline is optimal for patients with renal hypertension. A 30% BP drop is acceptable for patients with stable essential hypertension. Attaining normal BP level is acceptable and desirable for cases of labile essential hypertension.