[Characteristics of the metastatic spread of transplanted tumors under high-altitude conditions]. / Osobennosti metastazirovaniia perevivnykh opukholei v usloviiakh vysokogor'ia.

The data on nature of metastatic spreading of transplantable animal tumours of the Tien-Shan mountains at an altitude of 3200 m above sea level are reviewed. It is shown that the adaptation of mice with Ehrlich adenocarcinoma is followed by the primary tumour growth inhibition and a two-fold decrease of frequency of metastatic spreading into regional lymph nodes as compared with the control animals at sea level. In mountains the activity of metastatic spreading into lungs of Lewis lung carcinoma and Walker carcinosarcoma decreases. In experiments with (CBA x C57Bl)F1 mice-hybrids with Lewis lung carcinoma the enhancement of antitumour and antimetastatic effect of the cyclophosphamide is revealed under high-altitude hypoxia influence.

[Effect high-altitude conditions on the antitumor activity of cyclophosphane and its action on lymphoid tissue cells]. / Vliianie uslovii vysokogor'ia na protivoopukholevuiu aktivnost' tsiklofosfana i ego deistvie na kletki limfoidnoi tkani.

High-altitude hypoxia inhibits the Walker carcinosarcoma growth in rats and enhances the efficacy of antitumour treatment with cyclophosphane. Under mountain conditions the cyclophosphane toxicity effect on the lymphoid tissue decreased. As a response to cyclophosphane administration the depletion of the lymphocyte amount in the peripheral blood and cell populations in the thymus, spleen, lymph nodes of animals was less expressed at high altitude (3200 m) than at low one (760 m). In clinical research it was shown that high-altitude hypoxia may be used as a therapeutic factor in the management of cytostatic lymphocytopenias in cancer patients.

[Effect of high-altitude hypoxia on the effectiveness of chemotherapy in tumors]. / Vliianie vysokogornoi gipoksii na éffektivnost' khimioterapii opukholei.

It was shown in rat experiments that high-altitude hypoxia inhibits the growth of transplantable tumors and enhances the efficacy of antitumor treatment with chemotherapeutic drugs (thiotepa for Heren's carcinoma, and cyclophosphamide for sarcoma 45). Under high-altitude conditions, the cyclophosphamide toxicity as regards blood cells was modified, manifesting in the absence of anemization and less considerable reduction in the platelet and lymphocyte counts. The animals' adaptation to high-altitude hypoxia was followed by a rise in the blood content of sulfhydryl groups and increase in cancerolytic activity of the blood serum.