Acceptability of Prenatal Screening Tests Among Expectant Mothers in India: Insights and Implications for Public Health.

INTRODUCTION: Prenatal screening tests are essential for preventing common genetic disorders, yet their acceptability among pregnant women in India remains unexplored. This study aims to investigate the acceptability of prenatal screening tests and their correlation with demographic characteristics among pregnant women in India. METHODS: A cross-sectional study was conducted at a tertiary care, public hospital, involving 200 pregnant women. Data were collected through a self-administered questionnaire assessing demographic information and the acceptability of prenatal screening tests. Statistical analysis included chi-square tests and logistic regression. RESULTS: Most participants demonstrated adequate acceptability toward prenatal screening tests, with 73% scoring above the threshold. Factors associated with higher acceptability included younger maternal age, second-trimester gestational age, higher education, salaried employment, and urban residence. However, factors such as parity, consanguinity, mode of conception, and family history of genetic disease showed no significant associations. CONCLUSION: The study highlights positive attitudes toward prenatal screening tests among pregnant women in India, particularly among younger, more educated, and urban populations. These findings emphasize the need for targeted interventions to enhance awareness and accessibility of prenatal screening, ultimately contributing to the reduction of the genetic disorder burden in India.

Understanding the Awareness of Prenatal Genetic Screening Tests Among Pregnant Women in India: A Cross-Sectional Study.

Introduction Genetic disorders pose a significant health challenge in India, with chromosomal abnormalities ranking second only to congenital anomalies in terms of disease burden. Prenatal testing offers a crucial strategy for identifying and managing these disorders. However, the awareness and understanding of prenatal screening tests among pregnant women in India remain understudied. This study aims to fill this gap by investigating the awareness quotient of prenatal screening tests for genetic disorders among pregnant women in India. Methods A hospital-based cross-sectional study was conducted at the Genetics Unit, Department of Anatomy, and Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, Mangalagiri. Ethical clearance was obtained, and data were collected using a self-administered questionnaire covering demographic characteristics and awareness assessment. Descriptive statistics, chi-square tests, and logistic regression analysis were employed for data analysis. Results Among the 200 pregnant women surveyed, the majority demonstrated inadequate awareness of prenatal screening tests for genetic disorders, with only 36.5% possessing adequate knowledge. Significant associations were found between awareness levels and factors such as age, trimester of pregnancy, and education level. Notably, awareness about non-invasive prenatal testing (NIPT) was notably low at 7%, indicating a need for targeted educational interventions. Comparison with international studies revealed varying levels of awareness across different populations, highlighting the influence of socio-cultural factors and healthcare systems. Conclusion This study underscores the need for improved awareness of prenatal screening tests among pregnant women in India. Addressing disparities in awareness, particularly among younger age groups and those with lower education levels, is crucial for informed decision-making in prenatal care. Targeted educational interventions can empower pregnant women to make informed choices, ultimately contributing to better maternal and child health outcomes. Further research should explore the effectiveness of such interventions in diverse settings to enhance prenatal care delivery.

Knowledge, Attitude, and Practice About the Process of Genetic Counselling Among Clinicians.

Introduction Clinicians agree with the fact that the impact of genetics in the field of medicine is humongous. They have to cope with the rapid advances in the field of clinical genetics and offer the best treatment to the patients at the right time. Disease with an underlying genetic cause not only involves the patient but also the family and the community. In the process of genetic counseling, the patient and the family are educated about the genetic basis of the disorder. This helps the patient and the family to make a well-informed decision. It also helps to reduce the genetic burden of the disease in the community over a period of time. In this regard, knowledge, attitude, and practice about the process of genetic counseling among clinicians is imperative. Methods A structured pre-validated questionnaire was distributed amongst 60 clinicians from different departments. Their responses were assessed based on the Likert scale. The data obtained were analyzed using descriptive statistics and expressed in percentages.  Results In the present study, nearly 90% of the clinicians felt that it was important to gather a multi-generational family history of the patient and advise them about inheritance patterns, recurrence risk, and genetic tests for a disorder with an underlying genetic cause. The need to educate the family members regarding the importance of genetic tests and referral to appropriate support groups if they test positive for a genetic disorder receive a positive response. Mostly the participants agreed that parents of children and couples at risk of having a child affected by a genetic disease should undergo genetic counseling. Conclusion Clinicians may not always be aware of the underlying genetic cause and genetic tests available or may face a paucity of time to counsel the patient and the family. Genetic counseling needs to be done at length in multiple sessions, and it is essential to reduce the burden of genetic disorders in society.

Major complications following central neuraxial block - A multi-centre observational study in Maharashtra (MGMM CNB Study).

Background and Aims: Major complications of central neuraxial block (CNB) are rare and their incidence in India is not known. This information is essential for explaining risk and medico-legal concerns. The present multi-centre study in Maharashtra was conducted to provide insight into the characteristics of rare complications following this popular anaesthetic technique. Methods: Data were collected from 141 institutes to study the clinical profile of CNB. Incidence of complications like vertebral canal haematoma, abscess, meningitis, nerve injury, spinal cord ischaemia, fatal cardiovascular collapse, and drug errors was collected over one year. Complications were reviewed by audit committee to assess causation, severity, and outcome. 'Permanent' injury was defined as death or neurological symptoms persisting for more than six months. Results: Spinal anaesthesia (SA) was the most frequently used CNB in 88.76% patients. Bupivacaine and an adjuvant were used in 92.90% and 26.06% patients, respectively. Eight major complications (four neurological and four cardiac arrests) were reported in patients receiving SA. In seven of eight instances, SA was responsible or contributory for complication. The pessimistic incidence of complications (included cases where CNB was responsible; contribution was likely, unlikely and could not be commented) was 8.69/lakh and optimistic incidence (included cases where CNB was responsible or contribution was likely) was 7.61/lakh. 'Pessimistically' and 'optimistically' there were three deaths including one death due to quadriplegia following epidural haematoma after SA. Five out of eight patients recovered completely (62.5%). As only eight patients had complications of different types, it was difficult to establish statistical correlation of major complications with demographic or clinical parameters. Conclusion: This study was reassuring and suggested that the incidence of major complications following CNB was low in Maharashtra.

Morphometry and aberrant morphology of the adult human tricuspid valve leaflets.

The tricuspid valve complex has been studied since the beginning of the twentieth century, and variations in the structural orientation of the tricuspid leaflets has been reported before, as the occurrence of accessory leaflets poses a major problem during surgeries related to the tricuspid valve. In this study, 36 adult formalin-fixed human hearts were analyzed to compare the number, form and size of the tricuspid leaflets. The result shows that in right ventricles, the number of leaflets can vary from the routine three to as many as seven, and the localization of such accessory leaflets of the tricuspid valve differs between specimens. Five leaflet forms were the most common, and the 'typical' form of tricuspid valves with no accessory leaflets was only present in a small percentage of the cases studied. Measurements of the main and accessory leaflets showed that the anterior leaflets were the largest, followed by the inferior leaflets, while the septal and the accessory leaflets were the smallest in size. On the basis of these results, it is suggested that three leaflets of the tricuspid valve are relatively uncommon, with frequent occurrences of accessory leaflets. The multicuspidal form of the tricuspid valve therefore raises concern about understanding the functional and physiological significance of the accessory leaflets.

Topography, morphology and morphometry of coronary ostia - a cadaveric study

The right and left coronary ostia are located in relation with the sinus of Valsalva. The coronary ostia are located close to the aortic root, which is an important area for interventional cardiologists and radiologists. This study encompasses the topography, morphology and morphometry of the coronary Ostia. 90 cadaver heart specimens fixed in 10% formalin were dissected. Shape and location of the coronary ostia was determined. The diameter of the ostium and distance from the base of the cusp up to the ostium was measured with the help of a measuring scale. 76.6% of Right coronary ostia (RCO) and 73.3% of Left coronary ostia (LCO) were horizontally oval in shape. 16% of RCO and 23% LCO were circular and 7% of RCO and 10% of LCO were vertically oval in shape. The mean diameter of RCO & LCO was 2.5±1 mm and 2.8±1 mm respectively. 56.6% of Right coronary ostia and 52.2% of Left coronary ostia were located in the central (middle 1/3rd) position of the cusp. The ostia were located at a distance of 5-18 mm from the base of the cusp. The average diameter was 2.5 mm. The most common location was sinotubular and central, and the most common shape was horizontally oval. Occasionally, more than one ostium was seen in the right coronary sinus. Study of the topography, morphology and morphometry of coronary ostia is essential for cardiac interventional procedures done for diagnostic and therapeutic purposes

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Variations in the vascular supply of the upper one third of the sciatic nerve

The arteria comitans nervi ischiadica (ACNI), which is a branch of the inferior gluteal artery and represents the axial artery of the inferior extremity, supplies the sciatic nerve in gluteal region. The vascular supply of the upper 1/3rd of the sciatic nerve and the morphological details of the ACNI have not been characterized yet in detail. Hence, we studied the extraneuronal blood supply of the upper 1/3rd of the sciatic nerve by cadaveric dissection. The upper 1/3rd of the sciatic nerve was dissected in the gluteal region by reflecting the gluteus maximus muscle in 33 formalin-fixed cadavers. Variations in the number of ACNI arising from the inferior gluteal artery and length of segments of ACNI were noted. The source of other nutrient branches supplying the sciatic nerve in the gluteal region was also noted. In 86.6% of cases one ACNI was found. 9% of limbs had two ACNI and 1.8% had three ACNI arising respectively from the inferior gluteal artery (IGA). The morphology of the ACNI was studied in three segments and it showed variation in length. Blood supply to the sciatic nerve was assisted by the nutrient branches from trochanteric & cruciate anastomosis in 71% of cases, and branches from the artery accompanying the posterior cutaneous nerve of the thigh in 34% of cases. Both sources assisted blood supply in 3% of cases. Detailed knowledge of blood supply to the peripheral nerve is essential for surgeons dealing with peripheral nerve injuries

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Karapandzic flap.

For full-thickness lip defects, the choice of reconstructive option depends on the size of the defect. Defects of one-quarter to one-third of the upper lip can be closed primarily. Largerdefects measuring one-third to two-thirds of the lower lip width may be closed with the Karapandzic, Abbe or Estlander flaps. If the commissure is involved, both the Karapandzic and Estlander flaps may be used; however, the Karapandzic is probably the better choice because it is better at maintaining oral competence. In the case of larger lower lip defects (more than two-thirds of the lip), if there is sufficient adjacent cheek tissue, the surgeon may employ the Karapandzic (for defects up to three-fourths of the lower lip width) or the Bernard-Burow's techniques (to reconstruct the entire lower lip). A case of post-traumatic, lower lip defect, reconstructed with a bilateral karapandzic flap is presented here.