The sensitivity and specificity of computerized brush biopsy and scalpel biopsy in diagnosing oral premalignant lesions: A comparative study.

BACKGROUND: The diagnosis of oral malignancy and epithelial dysplasia has traditionally been based upon histopathological evaluation of full thickness biopsy from lesional tissue. As many studies had shown that incisional biopsy could cause progression of the tumors, many alternative methods of collection of samples had been tested. Oral brush biopsy is a transepithelial biopsy where it collects cells from basal cell layer noninvasively. AIM: To assess the diagnostic accuracy of brush biopsy when compared to histopathology in a group of patients with features of potentially malignancy. MATERIALS AND METHODS: In the present study, 60 cases of clinically diagnosed leukoplakia are selected and subjected to histopathology and brush biopsy. RESULTS AND CONCLUSION: Results showed that of 16 dysplasia cases confirmed by histopathology, only 12 were positively reported in oral brush biopsy. In 44 cases, the reports are same for histopathology and brush biopsy. The sensitivity of oral brush biopsy is 43.5% and specificity is 81.25% with a positive predictive value of 58.3%. Oral brush biopsy with molecular markers like tenascin and keratins can be an accurate diagnostic test.

Oral mucosal lichen planus in nine-year-old child.

Lichen planus (LP) is a fairly distinctive mucocutaneous disease. The etiology of the condition appears to be complex and multifactorial, with unique histopathological features. Immunofluorescence studies have provided some insight into a proposed immunopathogenesis. LP is seen frequently in the middle-aged and elderly population. The female-to-male ratio is approximately 2:1. Children are rarely affected. The incidence of oral LP in children is reportedly high among Asians. We present a 9-year-old Indian child with the documented clinical aspects, histopathology and immunofluorescence studies.

Oral lichen planus. A review.

Lichen planus is a unique but common inflammatory disorder that affects the skin, mucous membranes, nails and hair. Oral lichen planus (OLP) is among the more common mucosal conditions a clinician is likely to encounter in his or her practice. The etiology is unknown. Immunofluorescence studies have provided some insight into a proposed immunopathogenesis. Buccal mucosa, tongue and gingiva are more commonly involved. The question of malignant transformation of OLP remains controversial. Management of lichen planus can be challenging and discouraging for both the patient and physician. Treatment options should be assessed for attendant risks and benefits, and tailored to the extent and severity of disease.