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1.
J Med Primatol ; 39(5): 336-46, 2010 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-20444005

RESUMO

BACKGROUND: A 24-year-old, male chimpanzee (Pan troglodytes) developed acute tetraparesis. Magnetic resonance imaging showed a diffuse T2-weighted hyperintensive lesion, indicating inflammation at the C1-2 level. All infective, autoimmune, and vascular investigations were unremarkable. RESULTS AND CONCLUSIONS: The chimpanzee's condition most resembled acute transverse myelitis (ATM) in humans. The chimpanzee was in severe incapacitated neurological condition with bedridden status and required 24-hour attention for 2 months followed by special care for over a year. Initially, corticosteroid therapy was performed, and his neurological symptoms improved to some extent; however, the general condition of the chimpanzee deteriorated in the first 6 months after onset. Pressure ulcers had developed at various areas on the animal's body, as the bedridden status was protracted. Supportive therapy was continued, and the general condition, appetite, mobility, and pressure ulcers have slowly but synergistically recovered over the course of 2 years.


Assuntos
Doenças dos Símios Antropoides/diagnóstico , Mielite Transversa/veterinária , Pan troglodytes , Paresia/veterinária , Traumatismos da Medula Espinal/veterinária , Animais , Doenças dos Símios Antropoides/terapia , Diagnóstico Diferencial , Assistência de Longa Duração , Imageamento por Ressonância Magnética , Masculino , Mielite Transversa/diagnóstico , Estado Nutricional , Paresia/líquido cefalorraquidiano , Paresia/etiologia , Úlcera por Pressão/etiologia , Úlcera por Pressão/veterinária , Traumatismos da Medula Espinal/líquido cefalorraquidiano , Traumatismos da Medula Espinal/complicações , Traumatismos da Medula Espinal/diagnóstico , Traumatismos da Medula Espinal/terapia
2.
Cytogenet Genome Res ; 108(1-3): 248-54, 2005.
Artigo em Inglês | MEDLINE | ID: mdl-15545737

RESUMO

The terminal C-bands that are a specific feature of chimpanzee chromosomes were dissected using a molecular cytogenetic technique, PRINS, with primers for telomeric sequences, subterminal satellite, and retrotransposable elements (HERV-K and -W). These DNA elements jointly formed a large block of retrotransposable compound repeat DNA organization (RCRO) at the terminal C-band regions of 30 chromosomes, and are also located at the centromeric regions of some chromosomes. Additionally, a block consisting of all members of the RCRO has transposed to the middle (q31.1) of the long arm of chromosome 6, and three members, the subterminal satellite and the two HERVs, have integrated into the proximal region (q14.4) of the long arm of chromosome 14. Terminal RCROs seem to induce and prolong the bouquet stage in meiotic prophase, and to affect chiasma formation, together with interstitial RCROs. It is also postulated that RCROs may cause a position effect to gene expression, resulting in gene silencing and/or late replication.


Assuntos
Cromossomos de Mamíferos/genética , DNA/genética , Meiose/genética , Pan troglodytes/genética , Prófase/genética , Recombinação Genética/genética , Retroelementos/genética , Animais , Conformação de Ácido Nucleico , Pan paniscus/genética , Sequências Repetitivas de Ácido Nucleico/genética , Telômero/genética
3.
J Med Primatol ; 31(3): 129-35, 2002 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-12190853

RESUMO

In the last three decades, several monkeys reared in outdoor/indoor-outdoor breeding colonies and cages of the Primate Research Institute, Kyoto University, died of yersiniosis caused by Yersinia pseudotuberculosis, necessitating introduction of a method to detect the bacteria rapidly and thus allow preventive measures to be undertaken. A rapid nested polymerase chain reaction (PCR) method for identification of Y. pseudotuberculosis in fecal samples and a random amplified polymorphic DNA (RAPD)-PCR approach for distinguishing between bacterial strains were therefore developed. Yersinia pseudotuberculosis isolates from monkey specimens were found to be classifiable into several types. To determine the source of infection, hundreds of fecal samples of wild rats, pigeons, and sparrows were collected from around the breeding colonies and cages, and subjected to PCR analyses. Yersinia pseudotuberculosis was detected in 1.7% of the fecal samples of wild rats. The DNA fingerprints of the bacteria revealed by RAPD-PCR were the same as that of one strain isolated from macaques, suggesting the wild rat to be a possible source of infection.


Assuntos
Haplorrinos/microbiologia , Doenças dos Macacos/microbiologia , Técnica de Amplificação ao Acaso de DNA Polimórfico/métodos , Fatores de Virulência , Yersinia pseudotuberculosis/genética , Yersinia pseudotuberculosis/isolamento & purificação , Adesinas Bacterianas/genética , Animais , Animais Selvagens , Proteínas de Bactérias/genética , Primers do DNA , Fezes/microbiologia , Ratos , Yersinia pseudotuberculosis/classificação , Infecções por Yersinia pseudotuberculosis/microbiologia , Infecções por Yersinia pseudotuberculosis/transmissão , Infecções por Yersinia pseudotuberculosis/veterinária
4.
J Vet Med Sci ; 63(4): 361-6, 2001 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-11346168

RESUMO

To clarify the influence of rearing conditions on the growth of various body parts of Japanese macaques (Macaca fuscata), two groups reared under different conditions, i.e., a group born and reared in open enclosures (Enclosure group) and another consisting of macaques born and reared in cages (Caged group), were somatometrically analyzed. Somatometric data on 36 measures of various body parts were collected from 77 males and 92 females. Growth in many body parts was smaller in the Caged group than in the Enclosure group. Body parts that exhibited large incremental increases were more sensitive to differences in rearing space at the infantile growth stage in both sexes. Recovery from delayed growth at the pubertal growth stage was found in many body parts. However, the size of some locomotor elements such as the wrist and hand, and ankle and foot strongly reflected limitations of space and changes due to this were irreversible. Females were more sensitive than males to such differences in rearing conditions. We conclude that open enclosures with ample rearing space are necessary for the innate growth of Japanese macaques to occur.


Assuntos
Criação de Animais Domésticos/métodos , Animais de Laboratório/crescimento & desenvolvimento , Abrigo para Animais , Macaca/crescimento & desenvolvimento , Animais , Animais de Laboratório/fisiologia , Peso Corporal , Feminino , Macaca/fisiologia , Masculino
5.
Epilepsia ; 38(2): 182-8, 1997 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-9048670

RESUMO

PURPOSE: To clarify the electroclinical manifestation of epileptic seizures and the evolution of epilepsy in patients with peroxisomal diseases. METHODS: Retrospective review of the medical records and EEGs of 14 patients with peroxisomal diseases: seven with Zellweger syndrome (ZS), two with neonatal adrenoleukodystrophy (NALD), two with acyl-CoA oxidase deficiency (AOXD), two with bifunctional enzyme deficiency (BFED), and one with rhizomelic chondrodysplasia punctata (RCDP). The diagnoses were made by biochemical analysis and pathological examinations in our laboratory. RESULTS: Patients manifested serious neurologic deficits in the neonatal period or in early or late infancy. Patients with ZS or AOXD had partial motor seizures originating in the arms or legs or corners of the mouth. Their seizures did not culminate in generalized tonic-clonic seizures and were easily controlled by antiepileptic drugs (AEDs). Interictal EEGs of the patients with ZS showed infrequent bilateral independent multifocal spikes, predominantly in the frontal motor cortex and its surrounding regions. The EEGs of patients with AOXD showed interictal fast theta activity, predominantly in the frontocentral regions. Patients with BFED also had partial motor seizures in early infancy, but the seizures were intractable, evolving in one case to myoclonic seizures. Interictal EEGs of patients with BFED showed bilateral independent multifocal spikes that evolved to bilateral diffuse high-voltage slow waves in one case and to a hypsarythmic pattern in another case as the disease progressed. Patients with NALD had intractable tonic seizures or epileptic spasms. Interictal EEGs showed high-voltage slow waves and bilateral independent multifocal spikes, evolving in one patient to a flat pattern. The patient with RCDP, whose interictal EEGs showed frequent multifocal independent spikes, did not have epileptic seizures. CONCLUSIONS: The age of epilepsy onset or the duration of survival is related to the types of seizures occurring in patients with peroxisomal diseases. Neonates or young infants usually have partial motor seizures (facial twitching or clonic convulsions of the arms or legs) of various multifocal origins. Older infants may have generalized seizures at the onset of the disease or evolutionally. Seizure intractability is usually less severe in patients with ZS or AOXD than in patients with NALD or BFED. There is no relation between the electroclinical characteristics of epilepsy and the genetic complementation groups in peroxisomal diseases.


Assuntos
Eletroencefalografia , Epilepsia/diagnóstico , Transtornos Peroxissômicos/fisiopatologia , Acil-CoA Oxidase , Adrenoleucodistrofia/fisiopatologia , Anticonvulsivantes/uso terapêutico , Encéfalo/fisiopatologia , Criança , Pré-Escolar , Condrodisplasia Punctata Rizomélica/fisiopatologia , Epilepsia/tratamento farmacológico , Epilepsia/fisiopatologia , Humanos , Lactente , Recém-Nascido , Prontuários Médicos , Oxirredutases/deficiência , Estudos Retrospectivos , Síndrome de Zellweger/fisiopatologia
6.
Jikken Dobutsu ; 35(3): 339-44, 1986 Jul.
Artigo em Japonês | MEDLINE | ID: mdl-3770086

RESUMO

A system of predicting the time of parturition in the chimpanzee was developed to assure care of the newborn as soon as possible after delivery. To quantify activity, the number of times that a parturient chimpanzee crossed a sensor marker of a TV monitor was recorded by a videosensor on the market for crime prevention. The amount of activity increased remarkably just prior to parturition. A system using a personal pocket alarm ("beeper"), which rang automatically when the number of crossings by the chimpanzee exceeded a selected level within a certain period of time, was tested. In the present study, the threshold for sounding the alarm was set at 50 crossings within 10 minutes. As a result, the pocket alarm began to ring at about 40 minutes before parturition. This enabled us to be present at parturition and to tend to a newborn abandoned by its mother in one case. The present system could be useful to predict the time of parturition in the chimpanzee.


Assuntos
Trabalho de Parto/fisiologia , Monitorização Fisiológica/veterinária , Pan troglodytes/fisiologia , Gravação de Videoteipe , Animais , Feminino , Gravidez
7.
Jikken Dobutsu ; 34(2): 203-6, 1985 Apr.
Artigo em Japonês | MEDLINE | ID: mdl-4018154

RESUMO

Artificial inseminations were performed on two female chimpanzees from July 1981 to April 1983 and three conceptions were obtained. Semen samples collected by rectal probe method of electroejaculation were incubated at 37 degrees C for about 20 minutes for liquefaction. Liquefied portion of the semen was sucked up into polyethylene tube about 30 cm in length attached to a syringe and was inseminated into cervix of each female of which pelvic region was raised in prone position under anesthesia. Ovulation time was speculated by swelling of sex skin in earlier two cases and by urinary LH level in last case. Three offsprings were obtained 234, 235 and 235 days after last insemination, respectively. All of three show normal developments.


Assuntos
Inseminação Artificial/veterinária , Pan troglodytes , Animais , Feminino , Inseminação Artificial/métodos , Masculino
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