[An analysis of the micronuclei in the oral mucosa of cancer patients for assessing the clastogenic effect of chemical preparations]. / Analiz mikroiader v slizistoi rotovoi polosti onkologicheskikh bol'nykh dlia otsenki klastogennogo éffekta khimiopreparatov.

The frequency of micronuclei in the buccal mucosa cells have been investigated in healthy persons (donors) and patients with tumors before and after chemotherapy. It has been shown that frequency of micronuclei in the cells of patients before therapy and donors were at the same level. One day after chemotherapy the frequency of micronuclei was elevated 3.2 times.

[Relation of the antitumor activity of 4'-epidoxorubicin and cytogenetic disorders of tumor cells in experimental studies]. / Sviaz' protivoopukholevoi aktivnosti 4-épidoksorubitsina s narusheniiami geneticheskogo apparata opukholevykh kletok v éksperimente.

Antitumor and cytogenetic activities of 4-epi-doxorubicin (EDR), an anthracycline antibiotic, were studied on female Wistar rats with transplantable ascitic ovary tumor (OT). It was shown that after a single administration in a dose of 3 mg/kg, EDR prolonged the average lifespan of the tumor-bearing rats by 213.4 per cent as compared to that in the controls. The maximum number of the aberrant cells in the bone marrow was observed 24 hours after injection of EDR. In 6 day it decreased to the control level. The maximum increase in the number of the OT aberrant cells was recorded 2 days after EDR injection and even in 10 days the number of the aberrant cells amounted to 20.2 +/- 1.3 per cent. It is suggestive of a high selective action of EDR and relation between the EDR antitumor activity and the disturbances in the chromosomal apparatus of the OT cells.

[Antimutagenic properties of sea buckthorn oil]. / Antimutagennoe svoistvo oblepikhovogo masla.

The influence of sea-buckthorn oil on cyclophosphamide, farmorubicin and dioxadet mutagenicity was studied. The oil decreased significantly the cytogenetic action of cyclophosphamide and farmorubicin, but not of dioxadet action. Possible mechanisms of antimutagenic action of the oil are discussed.

[The cytogenetic action of x-ray irradiation on the myelokaryocytes of rats immunized with a tularemia vaccine]. / Izuchenie tsitogeneticheskogo deistviia rentgenovskogo oblucheniia na mielokariotsity krys, immunizirovannykh tuliaremiinoi vaktsinoi.

Immunization with tularemic live dry vaccine administered singularly to Wistar rats skin has been studied for its effect on mutagenicity induced after whole-body X irradiation. The analysis has shown that cytogenetic disturbance induced after X irradiation with doses of 0.5 Gy and 1.0 Gy in immunized animals significantly decreases as compared to nonimmunized animals.

[Decrease in the cytogenetic effect of adriblastin and pharmorubicin with the experimental use of tularemia vaccine]. / Snizhenie tsitogeneticheskogo deistviia adriblastina i farmorubitsinas pomoshch'iu tuliaremiinoi vaktsiny v éksperimente.

Immunization of Wistar rats with tularemic vaccine has been studied for its influence on the cytogenetic effect of adryblastine and pharmorubicyn. It is shown that the number of aberrant metaphases considerably decreases in the myelocaryocytes of vaccinated rats. Antimutagenic effect is induced by the influence of tularemic vaccine on the metabolic activation processes of antibiotics and, possibly, by an increase of the activity of antioxidative enzymes in the rat organism.

[The effect of tularemia vaccine on the radioresistance of white rats exposed to x-irradiation]. / Vliianie tuliaremiinoi vaktsiny na radioustoichivost' belykh krys pri rentgenovskom obluchenii.

A single epicutaneous vaccination of Wistar rats with tularemic live vaccine 15 days before X-irradiation with doses of 6.0, 8.0 and 2.0 + 6.0 Gy was shown to increase their radioresistance. With higher doses (up to 8.0 Gy) the effect of the vaccine was less pronounced.

[Possible mutagenic action of a tularemia vaccine]. / O vozmozhnom mutagennom deistvii tuliaremiinoi vaktsiny.

No increase in the number of chromosome aberrations in the bone marrow cells of the Wistar rats was observed on the 1st, 2nd, 7th and 15th days after epidermal and intradermal immunization by tularemic live vaccine. Subcutaneous injection of great quantities of tularemic microbic cells which were not used in practice increased the number of cells with chromosome aberrations only on the second day.

[Effect of the immunization of rats with tularemia vaccine on the number of cytogenetic disorders in somatic cells induced by cytostatics]. / Vliianie immunizatsii krys tuliaremiinoi vaktsinoi na kolichestvo tsitogeneticheskikh narushenii v somaticheskikh kletkakh, indutsiruemykh nekotorymi tsitostatikami.

Cytogenetic disturbances due to cytostatic preparations--cyclophosphamide and methylnitrosourea--applied as single or ten-times administrations in different doses have been studied for rats immunized with tularemia live dried vaccine. It is established that with the application of these preparations to immunized animals the quantity of chromosomal aberrations in myelokaryocytes decreased from 1.4 to 2.2 times, compared with that in non-immunized animals.

[Enhanced antitumor resistance in rats immunized with a tularemia vaccine]. / Povyshenie protivoopukholevoi rezistentnosti krys pri immunizatsii tuliaremiinoi vaktsinoi.

It is established that rat immunization with tularemia living vaccine inhibits Pliss lymphosarcoma growth and increases the life duration to tumour bearing animals. In tests with Zajdela ascitic hepatoma in 1/3 of the immunized animals ascites were not formed and the rats lived 150 days before they were killed.

[Effect of a live tularemia vaccine on chemical mutagenesis in white rats]. / Vliianie tuliaremiinoi zhivoi vaktsiny na khimicheskii mutagenez u belykh krys.

The influence of immunization with tularemic live dry vaccine applied singularly to Wistar rats skin on mutagenicity induced by cyclophosphamide, methylnitrosourea, benzo (a) pyrene, chloroprene and tetrachlorbutane was studied. The chemical compounds indicated were injected intraperitoneally at doses equal to one fifth of LD50 in 15 days after vaccination. The same doses of these chemicals were applied to intact rats (controls). Metaphase plates were prepared from rat bone marrows by known methods, 9600 metaphase cells were studied in total. The analysis showed that cytogenetic disturbances in immunized animals were significantly decreased (from 1.5 to 2.6 times), as compared to nonimmunized animals. The possible mechanisms of reducing the quantity of cytogenetic disorders in myelokaryocytes of immunized rats are discussed in this paper. The results obtained may be both of scientific and practical significance.

[Effect of immunization with live tularemia vaccine on the growth of various tumor strains in rats]. / Vliianie immunizatsii tuliaremiinoi zhivoi vaktsinoi na rost nekotorykh opukholevykh shtammov krys.

The paper deals with a study of the effect of a single challenge with living tularemia vaccine on the growth of such transplantable tumors as Zajdela's hepatoma, Pliss' lymphosarcoma, Walker's carcinosarcoma, Schwetz' erythromyelosis and sarcoma 45 in Wistar rats. Immunization was followed by a significant (37.2-86%) inhibition of the rate of growth of the said tumors. Ascites was detected in half the vaccinated animals of Zajdela's hepatoma series, this being matched by 100% in controls.