An Experimental Study on the Effects of Halothane Anesthesia on the Hepatic Function of Rats Pretreated with Ethyl Alcohol / 대한마취과학회지

The effects of halothane anesthesia on the liver function were investigated in 78 male Sprague-Dawley rats pretreated with ethyl alcohol. Blood sampling was done before intravenous administration of ethyl alcohol(400 mg/kg, 5 ml/kg, 9.99 vol %) or saline(5 ml/kg)through tail vein of the rat. Twentyfour hours later, all rats were randomly assigned to receive one of two anesthetic managements for two hours; 1) halothane -N2O-O2 2)N2O-O2 Bood sample and hepatic tissue were obtained 24 or 96 hours after anestheia Measurements of hepatic function(protein, albumin, cholesterol, bilirubin, blood urea nitro- gen, creatinine) were made and hepatic tissue was examined with light microscopy. The results are as follows; 1) There was no siginificant difference in the laboratory findings between the alcohol and saline groups. 2) There was no significant difference in the laboratory findings between the halothane and nitrous oxide anesthesia. 3) No difference in histologic injury was found between alcohol and saline groups. 4) No difference in histologic injury was found between halothane-nitrous oxide-oxygen and nitrous oxide-oxygen ansthesia groups.

Blood Pressure and Pulse Rate Responses to Extubation with and without Topical Tracheal Anesthesia / 대한마취과학회지

Usually, blood pressure and pulse rate are increased in the light planes of anesthesia at the end of operation especially just prior to extubation. The increasing of heart rate and blood pressure produce an elevation in cardiac work and oxygen demand and can lead to mycardial ischemia in patients with coronary artery disease. Tracheal anesthesia with 2 or 4% lidocaine (jelly and liquid) was done as a method which permits patients to be extubated during light planes of anesthesia. The results were as follows: 1) Each groups had similar blood pressure and pulse rate five or ten miriutes before extubation. 2) Lidocaine group did not have a significant elevation in systolic or diastolic blood pressure and pulse rate at or after extubation or in the recovery room. 3) The control group had significantly increases in both pressure and pulse rate(p<0.01). The data suggest that maneuver should be of advantage to patients with coronary artery disease who may not be able to tolerate the increased cardiac dynamics during extubation period.