RESUMO
DMAP reacts readily with chloromethylcycloalkyl ethers and alpha-chloroethyl alkyl ethers to give stable (1a-1e) and unstable (2a-2h) pyridinium chlorides. Reaction of these chlorides with NaOH produces the corresponding 4-pyridones. All the chlorides synthesized showed antibiotic activity. Particularly high activity against microbes representing cocci, rods, fungi, and bacilli was shown by 1-cyclododecyloxymethyl-4-dimethylaminopyridinium chloride 1d and 1-[(1-dodecyloxy)ethyl]-4-dimethylaminopyridinium chloride 2f.
Assuntos
Antibacterianos/síntese química , Compostos de Piridínio/síntese química , Antibacterianos/farmacologia , Bactérias/efeitos dos fármacos , Candida/efeitos dos fármacos , Espectroscopia de Ressonância Magnética , Testes de Sensibilidade Microbiana , Compostos de Piridínio/farmacologiaRESUMO
Synthesis and bacteriostatic properties of a new alkylthiomethylimidazole-linear and alkomethyly-limidazole-linear chlorides was described. It was found that these chlorides are active against bacilli, cocci and yeast-like fungi and express lower activity against rods. Highest activity was observed with 2-benzyl-3-decyloxymethyl-1--ethylimidazolinear and 1-ethyl-heptadecyl-3-undecyloxymethylimidazolelinear chlorides.
Assuntos
Bactérias/efeitos dos fármacos , Fungos/efeitos dos fármacos , Imidazóis/química , Imidazóis/síntese química , Imidazóis/farmacologiaRESUMO
Syntheses and antibacterial activity of 1-ethyl-2-alkyl-3-(alkoxymethyl)- and 1-ethyl-2-alkyl-3-(alkylthiomethyl)imidazolinium chlorides are described. Syntheses of the imidazolinium compounds were performed by reaction of 1-ethyl-2-alkylimidazoline with chloromethylalkyl ether or with chloromethylalkyl sulfide. Antimicrobial properties of obtained compounds was tested on 13 strains of bacteria and fungi. Chlorides with alkylthiomethyl residue showed the highest antimicrobial activity.