1.
Bioorg Med Chem
; 10(6): 1687-93, 2002 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11937327
RESUMO
Some novel quinoline derivatives were prepared and tested for antileishmanial activity. 2-(2-Methylquinolin-4-ylamino)-N-phenylacetamide (2) was found to be significantly more active than the standard antileishmanial drug sodium antimony gluconate (SAG) in reducing the parasite load both in the spleen and liver at a much lower concentration in hamster models. The results suggest that the compound could be exploited as an antileishmanial drug.