RESUMO
The aerial part of Nauplius aquaticus afforded a new sesquiterpene lactone with a humulanolide skeleton, 6,7,9,10-tetrahydroasteriscunolide (1), in addition to the known asteriscunolides A (2) and D (3). Their structures were established principally by two-dimensional NMR spectroscopy.
Assuntos
Asteraceae/química , Lactonas/isolamento & purificação , Plantas Medicinais/química , Sesquiterpenos/isolamento & purificação , Cromatografia em Camada Fina , Dicroísmo Circular , Cristalografia por Raios X , Lactonas/química , Ressonância Magnética Nuclear Biomolecular , Sesquiterpenos/química , TunísiaRESUMO
In the pursuit of new leishmanicidal natural products, 5,7,4'-trihydroxyflavan [1] and the new product, 5,7-dihydroxy-4'-methoxyflavan [2], were isolated from the Guianian medicinal plant Faramea guianensis.
Assuntos
Flavinas/isolamento & purificação , Plantas Medicinais/química , Animais , Antiprotozoários/farmacologia , Flavinas/farmacologia , Guiana , Leishmania/efeitos dos fármacos , Leishmaniose/tratamento farmacológico , Macrófagos/efeitos dos fármacos , Macrófagos/parasitologia , Camundongos , Camundongos Endogâmicos BALB CRESUMO
Crude extracts of seeds, leaves and barks of four Madagascan Calophyllum species: C. inophyllum, C. recedens, C. chapelieri, and C. verticullatum, have been tested for molluscicidal activity against Biomphalaria glabrata. All seed extracts showed significant activity. The major constituents of the most active Calophyllum species were examined. Some related coumarinic derivatives were synthesized in order to improve the biological activity. Among the compounds prepared, 5,7-dihydroxy-6-(2-methylbutyryl)-4-phenyl-coumarin presented an interesting molluscicidal activity.
Assuntos
Flavonoides/farmacologia , Lactonas/farmacologia , Moluscocidas/farmacologia , Plantas/química , Animais , Biomphalaria/efeitos dos fármacos , Flavonoides/síntese química , Flavonoides/isolamento & purificação , Lactonas/síntese química , Lactonas/isolamento & purificação , Madagáscar , Moluscocidas/síntese química , Moluscocidas/isolamento & purificaçãoRESUMO
Several new derivatives of the aldehydic functions of (+/-) gossypol are described: an hydrosoluble hydrazide resulting from the reaction with the Girard's reagent T and Schiff bases with polyamines. The condensation between the two aldehyde groups and cadaverine, putrescine or spermidine gives macrocyclic bridged products. A disubstituted non cyclic derivative is obtained with an excess of cadaverine. These products are of biological interest.